Literature DB >> 32767270

Do statutory holidays impact the number of opioid-related hospitalizations among Canadian adults? Findings from a national case-crossover study.

Chantal Houser1, David Huynh1, Amir Jasarevic1, Minh T Do1, Matthew Young2,3, Paul J Villeneuve4.   

Abstract

OBJECTIVE: In Canada, emergency department visits, hospitalizations, and deaths due to opioid use have risen substantially in recent years. While these events have exhibited seasonal and day of week patterns, there have been no attempts to investigate the extent to which statutory holidays influence these patterns, particularly opioid-related hospitalizations.
METHODS: We applied a time-stratified case-crossover study design to investigate whether statutory holidays were predictive of opioid-related hospitalizations using the Canadian Discharge Abstract Database (excluding Quebec) for fiscal years 2011/2012 to 2016/2017. This design controls for day of week effects. We restricted analyses to opioid hospitalizations (ICD-10 codes: F11.x, T40.0-T40.4, and T40.6) among individuals 15 years and older. Conditional logistic regression models were fit to estimate the odds of opioid-related hospitalization on holidays relative to non-holidays. We examined these patterns across different holiday types, namely social gathering holidays (e.g., Canada Day) and family holidays (e.g., Christmas). Stratified analyses were done to identify whether these associations varied by age group and sex.
RESULTS: We identified a total of 59,965 opioid-related hospitalizations. Overall, we found a 12% reduced odds in opioid hospitalizations on holidays (odds ratio [OR] = 0.88, 95% CI 0.83, 0.93) relative to non-holidays. Similar reductions were observed for both family (OR = 0.86, 95% CI 0.79, 0.93) and social gathering holidays (OR = 0.90, 95% CI 0.84, 0.96). No substantive differences were noted by age group or sex.
CONCLUSIONS: Our findings support the hypothesis that opioid-related hospitalizations occur less frequently on statutory holidays. This knowledge may help inform healthcare resources and health promotion activities to reduce the impacts of opioid use.

Entities:  

Keywords:  Canada; Case-crossover study design; Holidays; Hospitalization; Opioid overdose

Year:  2020        PMID: 32767270      PMCID: PMC7851201          DOI: 10.17269/s41997-020-00384-5

Source DB:  PubMed          Journal:  Can J Public Health        ISSN: 0008-4263


  22 in total

1.  The christmas effect on psychopathology.

Authors:  Randy A Sansone; Lori A Sansone
Journal:  Innov Clin Neurosci       Date:  2011-12

2.  Investigation of temporal changes of abuse and misuse of prescription opioids.

Authors:  Henry Spiller; J E Bailey; Richard C Dart; Sarah S Spiller
Journal:  J Addict Dis       Date:  2010-01

3.  Case-crossover analyses of air pollution exposure data: referent selection strategies and their implications for bias.

Authors:  Holly Janes; Lianne Sheppard; Thomas Lumley
Journal:  Epidemiology       Date:  2005-11       Impact factor: 4.822

4.  The case-crossover design: a method for studying transient effects on the risk of acute events.

Authors:  M Maclure
Journal:  Am J Epidemiol       Date:  1991-01-15       Impact factor: 4.897

5.  Association between cellular-telephone calls and motor vehicle collisions.

Authors:  D A Redelmeier; R J Tibshirani
Journal:  N Engl J Med       Date:  1997-02-13       Impact factor: 91.245

6.  Seasonality of alcohol-related hospital admissions has implications for prevention.

Authors:  K Poikolainen
Journal:  Drug Alcohol Depend       Date:  1982-09       Impact factor: 4.492

7.  Transient changes in behaviour lead to heroin overdose: results from a case-crossover study of non-fatal overdose.

Authors:  Paul Dietze; Damien Jolley; Craig Fry; Gabriele Bammer
Journal:  Addiction       Date:  2005-05       Impact factor: 6.526

Review 8.  Risk Factors for Opioid-Use Disorder and Overdose.

Authors:  Lynn R Webster
Journal:  Anesth Analg       Date:  2017-11       Impact factor: 5.108

9.  Gender differences in a clinical trial for prescription opioid dependence.

Authors:  R Kathryn McHugh; Elise E Devito; Dorian Dodd; Kathleen M Carroll; Jennifer Sharpe Potter; Shelly F Greenfield; Hilary Smith Connery; Roger D Weiss
Journal:  J Subst Abuse Treat       Date:  2013-01-11

Review 10.  Sex differences in opioid analgesia and addiction: interactions among opioid receptors and estrogen receptors.

Authors:  Cynthia Wei-Sheng Lee; Ing-Kang Ho
Journal:  Mol Pain       Date:  2013-09-08       Impact factor: 3.395

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