| Literature DB >> 32767141 |
Jie Zhang1, Zhi-Wei Ye1, Yvonne Janssen-Heininger2, Danyelle M Townsend3, Kenneth D Tew4.
Abstract
Glutathione S-transferase P (GSTP) is a component of a complex series of pathways that provide cellular redox homeostasis. It is an abundant protein in certain tumors and is over-expressed in cancer drug resistance. It has diverse cellular functions that include, thiolase activities with small electrophilic agents or susceptible cysteine residues on the protein to mediate S-glutathionylation, and chaperone binding with select protein kinases. Preclinical and clinical testing of a nanomolar inhibitor of GSTP, TLK199 (Telintra; Ezatiostat) has indicated a role for the enzyme in hematopoiesis and utility for the drug in the treatment of patients with myelodysplastic syndrome.Entities:
Keywords: Clinical trials; Cyclophosphamide; Drug resistance; Ezatiostat; Glutathione; Glutathione S-transferase; Glutathionylation; Hematopoiesis; Lung diseases; Myelodysplastic syndromes; Myeloproliferation; Oxidative stress; Telintra; c-Jun N-terminal kinases
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Year: 2021 PMID： 32767141 PMCID： PMC8963531 DOI： 10.1007/164_2020_392
Source DB: PubMed Journal: Handb Exp Pharmacol ISSN： 0171-2004