| Literature DB >> 32764038 |
Gabriel Tarrason Risa1, Fredrik Hurtig2, Sian Bray3, Anne E Hafner1,4,5, Lena Harker-Kirschneck1,4,5, Peter Faull6, Colin Davis6, Dimitra Papatziamou7, Delyan R Mutavchiev1, Catherine Fan1, Leticia Meneguello1, Andre Arashiro Pulschen1, Gautam Dey1, Siân Culley1, Mairi Kilkenny3, Diorge P Souza1, Luca Pellegrini3, Robertus A M de Bruin1, Ricardo Henriques1, Ambrosius P Snijders6, Anđela Šarić1,4,5, Ann-Christin Lindås2, Nicholas P Robinson8, Buzz Baum9,4.
Abstract
Sulfolobus acidocaldarius is the closest experimentally tractable archaeal relative of eukaryotes and, despite lacking obvious cyclin-dependent kinase and cyclin homologs, has an ordered eukaryote-like cell cycle with distinct phases of DNA replication and division. Here, in exploring the mechanism of cell division in S. acidocaldarius, we identify a role for the archaeal proteasome in regulating the transition from the end of one cell cycle to the beginning of the next. Further, we identify the archaeal ESCRT-III homolog, CdvB, as a key target of the proteasome and show that its degradation triggers division by allowing constriction of the CdvB1:CdvB2 ESCRT-III division ring. These findings offer a minimal mechanism for ESCRT-III-mediated membrane remodeling and point to a conserved role for the proteasome in eukaryotic and archaeal cell cycle control.Entities:
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Year: 2020 PMID： 32764038 PMCID： PMC7116001 DOI： 10.1126/science.aaz2532
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728