Literature DB >> 3276328

Mobilization of arachidonic acid from diacyl and ether-linked phospholipids in FMLP stimulated alveolar macrophages.

J Masliah1, M Bachelet, O Colard, G Bereziat, B B Vargaftig.   

Abstract

Exposure of [1 14C]AA labeled guinea-pig alveolar macrophages to FMLP for 15 min induced an extensive mobilization of AA from phospholipids. PC and PI mainly contributed to the AA release, and labeled PE remained unchanged. Analysis of ether-linked phospholipids showed a significant breakdown of labeled diacyl and alkyl-acyl PC and an increase in labeled alkenyl-acyl PE.

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Year:  1988        PMID: 3276328     DOI: 10.1016/0006-2952(88)90227-4

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN: 0006-2952            Impact factor:   5.858


  3 in total

1.  The effects of PAF-acether and FMLP on eicosanoid production in guinea pig alveolar macrophages.

Authors:  F J Zijlstra; M Bachelet; M A Vermeer; J E Vincent
Journal:  Agents Actions       Date:  1989-01

2.  Enhancement of the phospholipase A2 activity in fMLP-treated guinea-pig alveolar macrophages.

Authors:  J Masliah; M Bachelet; O Colard; B B Vargaftig; G Bereziat
Journal:  Agents Actions       Date:  1989-01

3.  Alveolar macrophages and eicosanoids but not neutrophils, mediate bronchoconstriction induced by FMLP in the guinea-pig.

Authors:  M A Boukili; M F Bureau; A Lellouch-Tubiana; J Lefort; M T Simon; B B Vargaftig
Journal:  Br J Pharmacol       Date:  1989-09       Impact factor: 8.739

  3 in total

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