Literature DB >> 32762265

Analysis of epigenetic aging in vivo and in vitro: Factors controlling the speed and direction.

Mieko Matsuyama1, Arne Søraas2, Sarah Yu1, Kyuhyeon Kim1, Evi X Stavrou1, Paolo F Caimi1, David Wald1,2, Marcos deLima1, John A Dahl2, Steve Horvath3,4, Shigemi Matsuyama1.   

Abstract

IMPACT STATEMENT: Aging is associated with DNA methylation (DNAm) changes. Recent advancement of the whole-genome DNAm analysis technology allowed scientists to develop DNAm-based age estimators. A majority of these estimators use DNAm data from a single tissue type such as blood. In 2013, a multi-tissue age estimator using DNAm pattern of 353 CpGs was developed by Steve Horvath. This estimator was named "epigenetic clock", and the improved version using DNAm pattern of 391 CpGs was developed in 2018. The estimated age by epigenetic clock is named DNAmAge. DNAmAge can be used as a biomarker of aging predicting the risk of age-associated diseases and mortality. Although the DNAm-based age estimators were developed, the mechanism of epigenetic aging is still enigmatic. The biological significance of epigenetic aging is not well understood, either. This minireview discusses the current understanding of the mechanism of epigenetic aging and the future direction of aging research.

Entities:  

Keywords:  DNA methylation; age; aging; epigenetic aging; hematopoietic stem cell; hypoxia

Year:  2020        PMID： 32762265      PMCID： PMC7787543          DOI： 10.1177/1535370220947015

Source DB:  PubMed          Journal:  Exp Biol Med (Maywood)        ISSN： 1535-3699


  57 in total

Review 1.  G-CSF: From granulopoietic stimulant to bone marrow stem cell mobilizing agent.

Authors:  Linda J Bendall; Kenneth F Bradstock
Journal:  Cytokine Growth Factor Rev       Date:  2014-07-23       Impact factor: 7.638

Review 2.  DNA methylation-based biomarkers and the epigenetic clock theory of ageing.

Authors:  Steve Horvath; Kenneth Raj
Journal:  Nat Rev Genet       Date:  2018-06       Impact factor: 53.242

3.  Validated Living Worldwide Supercentenarians 112+, Living and Recently Deceased: February 2020.

Authors:  Robert D Young; Waclaw Jan Kroczek
Journal:  Rejuvenation Res       Date:  2020-02       Impact factor: 4.663

4.  Telomere shortening and tumor formation by mouse cells lacking telomerase RNA.

Authors:  M A Blasco; H W Lee; M P Hande; E Samper; P M Lansdorp; R A DePinho; C W Greider
Journal:  Cell       Date:  1997-10-03       Impact factor: 41.582

5.  JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death.

Authors:  S Win; T A Than; J C Fernandez-Checa; N Kaplowitz
Journal:  Cell Death Dis       Date:  2014-01-09       Impact factor: 8.469

Review 6.  The Regulation of JNK Signaling Pathways in Cell Death through the Interplay with Mitochondrial SAB and Upstream Post-Translational Effects.

Authors:  Sanda Win; Tin Aung Than; Neil Kaplowitz
Journal:  Int J Mol Sci       Date:  2018-11-20       Impact factor: 5.923

7.  Aging of blood can be tracked by DNA methylation changes at just three CpG sites.

Authors:  Carola Ingrid Weidner; Qiong Lin; Carmen Maike Koch; Lewin Eisele; Fabian Beier; Patrick Ziegler; Dirk Olaf Bauerschlag; Karl-Heinz Jöckel; Raimund Erbel; Thomas Walter Mühleisen; Martin Zenke; Tim Henrik Brümmendorf; Wolfgang Wagner
Journal:  Genome Biol       Date:  2014-02-03       Impact factor: 13.583

8.  GWAS of epigenetic aging rates in blood reveals a critical role for TERT.

Authors:  Ake T Lu; Luting Xue; Elias L Salfati; Brian H Chen; Luigi Ferrucci; Daniel Levy; Roby Joehanes; Joanne M Murabito; Douglas P Kiel; Pei-Chien Tsai; Idil Yet; Jordana T Bell; Massimo Mangino; Toshiko Tanaka; Allan F McRae; Riccardo E Marioni; Peter M Visscher; Naomi R Wray; Ian J Deary; Morgan E Levine; Austin Quach; Themistocles Assimes; Philip S Tsao; Devin Absher; James D Stewart; Yun Li; Alex P Reiner; Lifang Hou; Andrea A Baccarelli; Eric A Whitsel; Abraham Aviv; Alexia Cardona; Felix R Day; Nicholas J Wareham; John R B Perry; Ken K Ong; Kenneth Raj; Kathryn L Lunetta; Steve Horvath
Journal:  Nat Commun       Date:  2018-01-26       Impact factor: 14.919

Review 9.  Granulocyte-colony stimulating factor and umbilical cord blood cell transplantation: Synergistic therapies for the treatment of traumatic brain injury.

Authors:  Michael G Liska; Ike Dela Peña
Journal:  Brain Circ       Date:  2017-10-12

Review 10.  Telomere Biology and Human Phenotype.

Authors:  Kara J Turner; Vimal Vasu; Darren K Griffin
Journal:  Cells       Date:  2019-01-19       Impact factor: 6.600
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  2 in total

1.  Mechanisms of aging, age-associated diseases, and lifespan determination.

Authors:  Shigemi Matsuyama
Journal:  Exp Biol Med (Maywood)       Date:  2020-09-09

2.  Associations of Plasma Folate and Vitamin B6 With Blood DNA Methylation Age: An Analysis of One-Carbon Metabolites in the VA Normative Aging Study.

Authors:  Jamaji C Nwanaji-Enwerem; Elena Colicino; Xu Gao; Cuicui Wang; Pantel Vokonas; Edward W Boyer; Andrea A Baccarelli; Joel Schwartz
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2021-04-30       Impact factor: 6.591
  2 in total

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