Literature DB >> 3276205

Decreased expression of HLA class II antigens on human uveal melanoma cells after in vivo X-ray irradiation.

M J Jager1, J P van der Pol, D de Wolff-Rouendaal, P T de Jong, D J Ruiter.   

Abstract

In order to determine the presence of HLA antigens on human uveal melanomas, we tested anti-HLA monoclonal antibodies on tissue sections of these tumors. A great variety in expression of HLA class I and II antigens was present. A significantly lower expression of HLA class II antigens was present on uveal melanomas that had been irradiated before enucleation. These tumors lacked a lymphocytic infiltrate in comparison with nonirradiated tumors. These data suggest that radiotherapy affects expression of histocompatibility antigens on tumors.

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Year:  1988        PMID： 3276205     DOI： 10.1016/0002-9394(88)90125-0

Source DB:  PubMed          Journal:  Am J Ophthalmol        ISSN： 0002-9394            Impact factor:   5.258


  6 in total

1.  HLA expression in a primary uveal melanoma, its cell line, and four of its metastases.

Authors:  D J Blom; L R Schurmans; I De Waard-Siebinga; D De Wolff-Rouendaal; J E Keunen; M J Jager
Journal:  Br J Ophthalmol       Date:  1997-11       Impact factor: 4.638

2.  HLA expression and tumor-infiltrating immune cells in uveal melanoma.

Authors:  I de Waard-Siebinga; C G Hilders; B E Hansen; J L van Delft; M J Jager
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1996-01       Impact factor: 3.117

3.  Monoclonal antibodies in detection of choroidal melanoma.

Authors:  P J Ringens; R van Haperen; C Vennegoor; P T de Jong; S G van Duinen; D J Ruiter; A W van der Kamp
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1989       Impact factor: 3.117

Review 4.  Human Leukocyte Antigen Class I Antigen-Processing Machinery Upregulation by Anticancer Therapies in the Era of Checkpoint Inhibitors: A Review.

Authors:  Ananthan Sadagopan; Theodoros Michelakos; Gabriella Boyiadzis; Cristina Ferrone; Soldano Ferrone
Journal:  JAMA Oncol       Date:  2022-03-01       Impact factor: 31.777

Review 5.  HLA Expression in Uveal Melanoma: An Indicator of Malignancy and a Modifiable Immunological Target.

Authors:  Zahra Souri; Annemijn P A Wierenga; Arend Mulder; Aart G Jochemsen; Martine J Jager
Journal:  Cancers (Basel)       Date:  2019-08-07       Impact factor: 6.639

6.  The effects of irradiation on major histocompatibility complex expression and lymphocytic infiltration in the normal rat brain and the 9L gliosarcoma brain tumor model.

Authors:  P Wen; J S Loeffler; J H Morris; L A Lampson
Journal:  J Neuroimmunol       Date:  1990-05       Impact factor: 3.478
  6 in total

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