| Literature DB >> 3276193 |
Abstract
The prophylactic use of 300 mg doxycycline at the time of an abortion was evaluated in a randomized controlled trial. In the group with negative chlamydia screening results, only two (0.4%) of 502 patients who received prophylactic treatment developed pelvic infection, compared with 15 (3.0%) of 497 patients who received placebos (p = 0.001). The same effectiveness was found in women with positive chlamydia screening results. Vomiting was the major side effect of the medication and could limit its use. A simulation of selective prophylaxis in women with negative chlamydia screening results showed that its selective use in patients with a history of gonorrhea or in nulliparous women with multiple sex partners could be nearly two thirds as effective as general prophylaxis.Entities:
Keywords: Abortion, Induced; Americas; Antibiotics--side effects; Antibiotics--therapeutic use; Bacterial And Fungal Diseases; Behavior; Canada; Chlamydia; Communicable Diseases; Demographic Factors; Developed Countries; Developing Countries; Diseases; Drugs; Family Planning; Fertility; Fertility Control, Postconception; Gonorrhea; Infections; Multiple Partners; North America; Northern America; Pelvic Infections; Population; Population Dynamics; Reproductive Behavior; Reproductive Tract Infections; Sex Behavior; Sexual Partners; Sexually Transmitted Diseases; Treatment; Vacuum Aspiration
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Year: 1988 PMID： 3276193 DOI： 10.1016/0002-9378(88)90787-9
Source DB: PubMed Journal: Am J Obstet Gynecol ISSN： 0002-9378 Impact factor: 8.661