Letícia Copatti Dogenski1, Sara de Figueiredo Ribeiro2, Diego José Gambin3, Patrícia Canova Maso3, Maria Salete Sandini Linden4, Micheline Sandini Trentin5, Bernardo Zoehler6, Marcelo Macedo Crivelini7, João Paulo De Carli8. 1. Post-Graduate Program in Oral Diagnosis, Faculty of Dentistry, Federal University of Santa Catarina, Florianópolis, Brazil. leticiacdogenski@gmail.com. 2. Faculty of Dentistry, University of Passo Fundo, Passo Fundo, Brazil. 3. Post-Graduate Program in Dentistry, Faculty of Dentistry, University of Passo Fundo, Passo Fundo, Brazil. 4. Department of Implantology, Faculty of Dentistry, University of Passo Fundo, Passo Fundo, Brazil. 5. Department of Periodontics, Faculty of Dentistry, University of Passo Fundo, Passo Fundo, Brazil. 6. Institude of Biological Sciences, University of Passo Fundo, Passo Fundo, Brazil. 7. Department of Oral Pathology, Faculty of Dentistry, Júlio de Mesquita Filho São Paulo State University (UNESP), Araçatuba, Brazil. 8. Departments of Oral Medicine and Prosthodontics, Faculty of Dentistry, University of Passo Fundo, Passo Fundo, Brazil.
Abstract
OBJECTIVE: To perform an epidemiological survey comparing the cell proliferative activity of 107 cases of oral leukoplakia with their clinical and histopathological characteristics. MATERIALS AND METHODS: A cross-sectional, observational, and histological-histochemical study. The cases came from the Histopathological Diagnostic Service of UPF/RS and the School of Dentistry of Araçatuba FOA/UNESP/SP (1986-2016). The histopathological sections were stained using the silver staining (AgNOR) technique and the nuclei of 100 epithelial cells selected randomly were recorded to count the number of nucleolar organizer regions (NORs). The mean NORs per lesion were correlated to clinical and histological characteristics using ANOVA, at 5% significance. RESULTS: Most of the cases included men (62.62%), white (64.49%), and with an average age of 53.94 years. The most probable etiological factors were smoking (44.7%) and alcohol consumption (9.85%). The evolution time of most lesions was fast (33.65%), manifesting mainly in the form of plaques (70.37%) and without symptoms (58.88%). They were located mainly in the cheek mucosa (26.62%) and presented white color (66.35%), well-defined edges (59.81%), firm consistency (47.5%), and keratinized surface (49.53%). Etiological factor (p = 0.003), evolution time (p = 0.006), symptoms (p = 0.029), location (p = 0.020), consistency (p = 0.047), histopathological characteristics (p = 0.004), and superficial keratinization (p = 0.001) were statistically significant regarding the mean NORs of the leukoplakias studied. CLINICAL RELEVANCE: Oral leukoplakias caused by alcohol consumption and/or tobacco use, considering an evolution time of fewer than 12 months, asymptomatic, located in the lower lip or tongue, and with a firm consistency and increased superficial keratinization should be treated more aggressively by the clinician to avoid cancerization.
OBJECTIVE: To perform an epidemiological survey comparing the cell proliferative activity of 107 cases of oral leukoplakia with their clinical and histopathological characteristics. MATERIALS AND METHODS: A cross-sectional, observational, and histological-histochemical study. The cases came from the Histopathological Diagnostic Service of UPF/RS and the School of Dentistry of Araçatuba FOA/UNESP/SP (1986-2016). The histopathological sections were stained using the silver staining (AgNOR) technique and the nuclei of 100 epithelial cells selected randomly were recorded to count the number of nucleolar organizer regions (NORs). The mean NORs per lesion were correlated to clinical and histological characteristics using ANOVA, at 5% significance. RESULTS: Most of the cases included men (62.62%), white (64.49%), and with an average age of 53.94 years. The most probable etiological factors were smoking (44.7%) and alcohol consumption (9.85%). The evolution time of most lesions was fast (33.65%), manifesting mainly in the form of plaques (70.37%) and without symptoms (58.88%). They were located mainly in the cheek mucosa (26.62%) and presented white color (66.35%), well-defined edges (59.81%), firm consistency (47.5%), and keratinized surface (49.53%). Etiological factor (p = 0.003), evolution time (p = 0.006), symptoms (p = 0.029), location (p = 0.020), consistency (p = 0.047), histopathological characteristics (p = 0.004), and superficial keratinization (p = 0.001) were statistically significant regarding the mean NORs of the leukoplakias studied. CLINICAL RELEVANCE: Oral leukoplakias caused by alcohol consumption and/or tobacco use, considering an evolution time of fewer than 12 months, asymptomatic, located in the lower lip or tongue, and with a firm consistency and increased superficial keratinization should be treated more aggressively by the clinician to avoid cancerization.
Authors: A Martorell-Calatayud; R Botella-Estrada; J V Bagán-Sebastián; O Sanmartín-Jiménez; C Guillén-Barona Journal: Actas Dermosifiliogr Date: 2009-10
Authors: Anand Kumar; Luke Cascarini; James A McCaul; Cyrus J Kerawala; Darryl Coombes; Daryl Godden; Peter A Brennan Journal: Br J Oral Maxillofac Surg Date: 2012-11-14 Impact factor: 1.651
Authors: Nina Gale; Rok Blagus; Samir K El-Mofty; Tim Helliwell; Manju L Prasad; Ann Sandison; Metka Volavšek; Bruce M Wenig; Nina Zidar; Antonio Cardesa Journal: Histopathology Date: 2014-05-21 Impact factor: 5.087
Authors: Oreste Iocca; Thomas P Sollecito; Faizan Alawi; Gregory S Weinstein; Jason G Newman; Armando De Virgilio; Pasquale Di Maio; Giuseppe Spriano; Simón Pardiñas López; Rabie M Shanti Journal: Head Neck Date: 2019-12-05 Impact factor: 3.147
Authors: Marta Cristaldi; Rodolfo Mauceri; Olga Di Fede; Giovanna Giuliana; Giuseppina Campisi; Vera Panzarella Journal: Front Physiol Date: 2019-12-10 Impact factor: 4.566
Authors: Hussain G Ahmed; Amel B El Hag; Naif K Binsaleh; Gamal Eldin Mohamed O Elhussein; Malik Asif Hussain; Mohamed Ahmed Babikir I Bealy; Emad Abboh A Abboh; Hisham Sherfi Journal: Cureus Date: 2020-11-28