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Literature DB >> 32759187

Exploring the Therapeutic Potential of Protein Tyrosine Phosphatase 1B in hAPP-J20 Mouse Model of Alzheimer's Disease.

Judy Ghalayini^1,2.

Abstract

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2020 PMID： 32759187 PMCID： PMC7406278 DOI： 10.1523/JNEUROSCI.0852-20.2020

Source DB: PubMed Journal: J Neurosci ISSN： 0270-6474 Impact factor: 6.167

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20 in total

Review 1. GSK-3: tricks of the trade for a multi-tasking kinase.

Authors: Bradley W Doble; James R Woodgett
Journal: J Cell Sci Date: 2003-04-01 Impact factor: 5.285

2. Forecasting the global burden of Alzheimer's disease.

Authors: Ron Brookmeyer; Elizabeth Johnson; Kathryn Ziegler-Graham; H Michael Arrighi
Journal: Alzheimers Dement Date: 2007-07 Impact factor: 21.566

Review 3. Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transduction.

Authors: Nicholas K Tonks
Journal: FEBS J Date: 2013-01-17 Impact factor: 5.542

4. Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline.

Authors: Konrad Talbot; Hoau-Yan Wang; Hala Kazi; Li-Ying Han; Kalindi P Bakshi; Andres Stucky; Robert L Fuino; Krista R Kawaguchi; Andrew J Samoyedny; Robert S Wilson; Zoe Arvanitakis; Julie A Schneider; Bryan A Wolf; David A Bennett; John Q Trojanowski; Steven E Arnold
Journal: J Clin Invest Date: 2012-04 Impact factor: 14.808

5. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers.

Authors: Theresa R Bomfim; Leticia Forny-Germano; Luciana B Sathler; Jordano Brito-Moreira; Jean-Christophe Houzel; Helena Decker; Michael A Silverman; Hala Kazi; Helen M Melo; Paula L McClean; Christian Holscher; Steven E Arnold; Konrad Talbot; William L Klein; Douglas P Munoz; Sergio T Ferreira; Fernanda G De Felice
Journal: J Clin Invest Date: 2012-04 Impact factor: 14.808

6. Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein.

Authors: B J Goldstein; A Bittner-Kowalczyk; M F White; M Harbeck
Journal: J Biol Chem Date: 2000-02-11 Impact factor: 5.157

Exploring the Therapeutic Potential of Protein Tyrosine Phosphatase 1B in hAPP-J20 Mouse Model of Alzheimer's Disease.

Review 1. GSK-3: tricks of the trade for a multi-tasking kinase.

2. Forecasting the global burden of Alzheimer's disease.

Review 3. Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transduction.

4. Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline.

5. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers.

6. Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein.

Review 7. Alzheimer's disease: the challenge of the second century.

8. Control of synaptic vesicle endocytosis by an extracellular signalling molecule.

9. Central regulation of metabolism by protein tyrosine phosphatases.

10. A novel role for protein tyrosine phosphatase 1B as a positive regulator of neuroinflammation.

1. A Computer-Driven Scaffold-Hopping Approach Generating New PTP1B Inhibitors from the Pyrrolo[1,2-a]quinoxaline Core.