Literature DB >> 3275586

Killing of Proteus mirabilis by polymorphonuclear leukocyte granule proteins: evidence for species specificity by antimicrobial proteins.

W M Shafer1, S A Engle, L E Martin, J K Spitznagel.   

Abstract

Low-molecular-weight (Mr, ca. 3,800) polypeptides containing human defensins HNP-1 and HNP-2 (T. Ganz, M. S. Selsted, D. Szlarek, S. L. Harwig, K. Daher, D. F. Bainton, and R. I. Lehrer, J. Clin. Invest. 76:1427-1434, 1985) prepared in our laboratory from acid extracts of human polymorphonuclear granulocyte granules and purified human defensins were found to exert potent bactericidal action against Proteus mirabilis. The antimicrobial action of the extracts of human polymorphonuclear leukocytes granules against P. mirabilis appears to be due to the presence of the defensins. Because P. mirabilis resists the antimicrobial action of other granule proteins, we interpret the present results to mean that the various antimicrobial proteins display species specificity in their microbicidal action.

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Year:  1988        PMID： 3275586      PMCID： PMC259232          DOI： 10.1128/iai.56.1.51-53.1988

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  11 in total

1.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

2.  A spontaneous mutant of Neisseria gonorrhoeae with decreased resistance to neutrophil granule proteins.

Authors:  W M Shafer; V Onunka; P J Hitchcock
Journal:  J Infect Dis       Date:  1986-05       Impact factor: 5.226

3.  Arginine-rich proteins of polymorphonuclear leukocyte lysosomes. Antimicrobial specificity and biochemical heterogeneity.

Authors:  H I Zeya; J K Spitznagel
Journal:  J Exp Med       Date:  1968-05-01       Impact factor: 14.307

4.  Lipid A and resistance of Salmonella typhimurium to antimicrobial granule proteins of human neutrophil granulocytes.

Authors:  W M Shafer; S G Casey; J K Spitznagel
Journal:  Infect Immun       Date:  1984-03       Impact factor: 3.441

5.  Characterization of the lipopolysaccharide from the polymyxin-resistant pmrA mutants of Salmonella typhimurium.

Authors:  M Vaara; T Vaara; M Jensen; I Helander; M Nurminen; E T Rietschel; P H Mäkelä
Journal:  FEBS Lett       Date:  1981-06-29       Impact factor: 4.124

6.  Susceptibility of lipopolysaccharide mutants to the bactericidal action of human neutrophil lysosomal fractions.

Authors:  R F Rest; M H Cooney; J K Spitznagel
Journal:  Infect Immun       Date:  1977-04       Impact factor: 3.441

7.  Cationic antimicrobial proteins isolated from human neutrophil granulocytes in the presence of diisopropyl fluorophosphate.

Authors:  W M Shafer; L E Martin; J K Spitznagel
Journal:  Infect Immun       Date:  1984-07       Impact factor: 3.441

8.  Late intraphagosomal hydrogen ion concentration favors the in vitro antimicrobial capacity of a 37-kilodalton cationic granule protein of human neutrophil granulocytes.

Authors:  W M Shafer; L E Martin; J K Spitznagel
Journal:  Infect Immun       Date:  1986-09       Impact factor: 3.441

9.  Chemical structure of the lipid A component of the lipopolysaccharide from a Proteus mirabilis Re-mutant.

Authors:  Z Sidorczyk; U Zähringer; E T Rietschel
Journal:  Eur J Biochem       Date:  1983-12-01

10.  Defensins. Natural peptide antibiotics of human neutrophils.

Authors:  T Ganz; M E Selsted; D Szklarek; S S Harwig; K Daher; D F Bainton; R I Lehrer
Journal:  J Clin Invest       Date:  1985-10       Impact factor: 14.808
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  7 in total

Review 1.  Agents that increase the permeability of the outer membrane.

Authors:  M Vaara
Journal:  Microbiol Rev       Date:  1992-09

Review 2.  Antibiotic proteins of human neutrophils.

Authors:  J K Spitznagel
Journal:  J Clin Invest       Date:  1990-11       Impact factor: 14.808

3.  Differential killing of Actinobacillus actinomycetemcomitans and Capnocytophaga spp. by human neutrophil granule components.

Authors:  K T Miyasaki; A L Bodeau; T F Flemmig
Journal:  Infect Immun       Date:  1991-10       Impact factor: 3.441

4.  Synthetic bactericidal peptide based on CAP37: a 37-kDa human neutrophil granule-associated cationic antimicrobial protein chemotactic for monocytes.

Authors:  H A Pereira; I Erdem; J Pohl; J K Spitznagel
Journal:  Proc Natl Acad Sci U S A       Date:  1993-05-15       Impact factor: 11.205

5.  In vitro sensitivity of oral, gram-negative, facultative bacteria to the bactericidal activity of human neutrophil defensins.

Authors:  K T Miyasaki; A L Bodeau; T Ganz; M E Selsted; R I Lehrer
Journal:  Infect Immun       Date:  1990-12       Impact factor: 3.441

6.  Effect of lipopolysaccharide (LPS) chain length on interactions of bactericidal/permeability-increasing protein and its bioactive 23-kilodalton NH2-terminal fragment with isolated LPS and intact Proteus mirabilis and Escherichia coli.

Authors:  C Capodici; S Chen; Z Sidorczyk; P Elsbach; J Weiss
Journal:  Infect Immun       Date:  1994-01       Impact factor: 3.441

Review 7.  Bioactive Antimicrobial Peptides as Therapeutics for Corneal Wounds and Infections.

Authors:  Gina L Griffith; Anne Kasus-Jacobi; H Anne Pereira
Journal:  Adv Wound Care (New Rochelle)       Date:  2017-06-01       Impact factor: 4.730
  7 in total

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