Literature DB >> 32755606

A Vectorial, ER-Mitochondria Link to Energy Homeostasis in the Vascular Endothelium.

Nabil E Boutagy1, Joseph W Fowler1, William C Sessa2.   

Abstract

The precise mechanisms of free fatty acid (FFA) uptake in the vascular endothelium are unclear. In this issue of Cell Metabolism, Ibrahim et al. (2020) discover that FFA uptake is partially mediated by a vectorial, ER-mitochondria link, in which mitochondrial ATP production is locally used for the acyl-CoA synthetase activity of the ER-located fatty acid transport protein 4.
Copyright © 2020 Elsevier Inc. All rights reserved.

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Year:  2020        PMID: 32755606      PMCID: PMC7652390          DOI: 10.1016/j.cmet.2020.07.010

Source DB:  PubMed          Journal:  Cell Metab        ISSN: 1550-4131            Impact factor:   27.287


  16 in total

1.  Fatty acid degradation in Escherichia coli. An inducible acyl-CoA synthetase, the mapping of old-mutations, and the isolation of regulatory mutants.

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Journal:  Eur J Biochem       Date:  1969-02

Review 2.  Fatty acid transport: the roads taken.

Authors:  Jean E Schaffer
Journal:  Am J Physiol Endocrinol Metab       Date:  2002-02       Impact factor: 4.310

3.  Metabolism of exogenous substrates by coronary endothelial cells in culture.

Authors:  A Krützfeldt; R Spahr; S Mertens; B Siegmund; H M Piper
Journal:  J Mol Cell Cardiol       Date:  1990-12       Impact factor: 5.000

4.  Structural, functional, and antigenic differences between bovine heart endothelial CD36 and human platelet CD36.

Authors:  D E Greenwalt; K W Watt; T Hasler; R J Howard; S Patel
Journal:  J Biol Chem       Date:  1990-09-25       Impact factor: 5.157

5.  Lipid Droplet Biogenesis and Function in the Endothelium.

Authors:  Andrew Kuo; Monica Y Lee; William C Sessa
Journal:  Circ Res       Date:  2017-01-24       Impact factor: 17.367

6.  Role of neutral amino acid transport and protein breakdown for substrate supply of nitric oxide synthase in human endothelial cells.

Authors:  Alexandra Simon; Lars Plies; Alice Habermeier; Ursula Martiné; Marco Reining; Ellen I Closs
Journal:  Circ Res       Date:  2003-09-25       Impact factor: 17.367

7.  Fatty acid binding protein 4 is a target of VEGF and a regulator of cell proliferation in endothelial cells.

Authors:  Harun Elmasri; Cagatay Karaaslan; Yaroslav Teper; Elisa Ghelfi; Meiqian Weng; Tan A Ince; Harry Kozakewich; Joyce Bischoff; Sule Cataltepe
Journal:  FASEB J       Date:  2009-07-22       Impact factor: 5.191

8.  NanoSIMS Analysis of Intravascular Lipolysis and Lipid Movement across Capillaries and into Cardiomyocytes.

Authors:  Cuiwen He; Thomas A Weston; Rachel S Jung; Patrick Heizer; Mikael Larsson; Xuchen Hu; Christopher M Allan; Peter Tontonoz; Karen Reue; Anne P Beigneux; Michael Ploug; Andrea Holme; Matthew Kilburn; Paul Guagliardo; David A Ford; Loren G Fong; Stephen G Young; Haibo Jiang
Journal:  Cell Metab       Date:  2018-05-01       Impact factor: 27.287

9.  TNF-α induces acyl-CoA synthetase 3 to promote lipid droplet formation in human endothelial cells.

Authors:  Hye Seung Jung; Masami Shimizu-Albergine; Xia Shen; Farah Kramer; Dan Shao; Anuradha Vivekanandan-Giri; Subramaniam Pennathur; Rong Tian; Jenny E Kanter; Karin E Bornfeldt
Journal:  J Lipid Res       Date:  2019-11-13       Impact factor: 5.922

10.  Fatty acid carbon is essential for dNTP synthesis in endothelial cells.

Authors:  Sandra Schoors; Ulrike Bruning; Rindert Missiaen; Karla Cs Queiroz; Gitte Borgers; Ilaria Elia; Annalisa Zecchin; Anna Rita Cantelmo; Stefan Christen; Jermaine Goveia; Ward Heggermont; Lucica Goddé; Stefan Vinckier; Paul P Van Veldhoven; Guy Eelen; Luc Schoonjans; Holger Gerhardt; Mieke Dewerchin; Myriam Baes; Katrien De Bock; Bart Ghesquière; Sophia Y Lunt; Sarah-Maria Fendt; Peter Carmeliet
Journal:  Nature       Date:  2015-04-01       Impact factor: 49.962

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