Katie A Edwards1,2, Jacqueline J Leete1, Anna E Tschiffely3, Candace Y Moore1, Kristine C Dell4, Jonathan K Statz2,3, Walter Carr5, Peter B Walker6,7,8,9, Matthew L LoPresti10, Stephen T Ahlers11, Angela M Yarnell11, Jessica Gill1,12. 1. National Institute of Nursing Research, National Institutes of Health , Bethesda, MD, USA. 2. Henry M. Jackson Foundation, Bethesda, MD, USA. 3. Department of Neurotrauma, Naval Medical Research Center , Silver Spring, MD, USA. 4. Department of Psychology, Pennsylvania State University, University Park, PA, USA. 5. Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA. 6. Joint Artificial Intelligence Center, Arlington, VA, USA. 7. National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. 8. Department of Radiology and Medical Imaging, University of Virginia, Charlottesville , VA, USA. 9. Military Emergency Medicine Department, Uniformed Services, University of the Health Sciences, Bethesda , MD, USA. 10. Center for Military Psychiatry & Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD, USA. 11. Operational & Undersea Medicine Directorate, Naval Medical Research Center, Silver Spring, MD, USA. 12. Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda , MD, USA.
Abstract
OBJECTIVES: To evaluate how blast exposure impacts peripheral biomarkers. in military personnel enrolled in 10-day blast training. METHODS: On day 7, 21 military personnel experienced peak overpressure <2 pounds per square inch (psi); while 29 military personnel experienced peak overpressure ≥5 psi. Blood samples were collected each day to measure changes in amyloid beta (Aβ), neurofilament light chain (NFL), and tau concentrations. RESULTS: Within 24 hours following exposure ≥5 psi, the ≥5 psi group had lower Aβ42 (p = .004) and NFL (p < .001) compared to the <2 psi group and lower Aβ42 (9.35%) and NFL (22.01%) compared to baseline. Twenty-four hours after ≥5 psi exposure, the ≥5 psi group had lower tau (p < .001) and NFL (p < .001) compared to the <2 psi group and baseline. Seventy-two hours after exposure ≥5 psi, tau increased in the ≥5 psi group compared to the <2 psi group (p = .02) and baseline. The tau:Aβ42 ratio 24 hours after blast (p = .012), and the Aβ40:Aβ42 ratio 48 hours after blast (p = .04) differed in the ≥5 psi group compared to the <2 psi group. CONCLUSIONS: These findings provide an initial report of acute alterations in biomarker concentrations following blast exposure.
OBJECTIVES: To evaluate how blast exposure impacts peripheral biomarkers. in military personnel enrolled in 10-day blast training. METHODS: On day 7, 21 military personnel experienced peak overpressure <2 pounds per square inch (psi); while 29 military personnel experienced peak overpressure ≥5 psi. Blood samples were collected each day to measure changes in amyloid beta (Aβ), neurofilament light chain (NFL), and tau concentrations. RESULTS: Within 24 hours following exposure ≥5 psi, the ≥5 psi group had lower Aβ42 (p = .004) and NFL (p < .001) compared to the <2 psi group and lower Aβ42 (9.35%) and NFL (22.01%) compared to baseline. Twenty-four hours after ≥5 psi exposure, the ≥5 psi group had lower tau (p < .001) and NFL (p < .001) compared to the <2 psi group and baseline. Seventy-two hours after exposure ≥5 psi, tau increased in the ≥5 psi group compared to the <2 psi group (p = .02) and baseline. The tau:Aβ42 ratio 24 hours after blast (p = .012), and the Aβ40:Aβ42 ratio 48 hours after blast (p = .04) differed in the ≥5 psi group compared to the <2 psi group. CONCLUSIONS: These findings provide an initial report of acute alterations in biomarker concentrations following blast exposure.
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