Brian C Lentle1, Claudie Berger2, Jacques P Brown3, Linda Probyn4, Lisa Langsetmo5, Ian Hammond6, Jeff Hu1, William D Leslie7, Jerilynn C Prior1, David A Hanley8, Jonathan D Adachi9, Robert G Josse10, Angela M Cheung11, Stephanie M Kaiser12, Tanveer Towheed13, Christopher S Kovacs14, Andy Kin On Wong15, David Goltzman2. 1. 8166The University of British Columbia, Victoria, British Columbia, Canada. 2. 54473McGill University Health Centre, Montreal, Quebec, Canada. 3. 4440Laval University, Quebec, Canada. 4. Sunnybrook Health Sciences Centre, 7938Toronto, Ontario, Canada. 5. 5635University of Minnesota, Minneapolis, MN, USA. 6. Ottawa Hospital-General Campus, Ottawa, Ontario, Canada. 7. University of Manitoba, Winnipeg, Manitoba, Canada. 8. McCaig Institute for Bone and Joint Health, 2129University of Calgary, Calgary, Alberta, Canada. 9. 3710McMaster University, Hamilton, Ontario, Canada. 10. 12366University of Toronto Faculty of Medicine, St. Michael's Hospital, Toronto, Ontario, Canada. 11. University of Toronto, Toronto, Ontario, Canada. 12. 3688Dalhousie University, VG Site, Halifax, Nova Scotia, Canada. 13. 4257Queen's University, Kingston, Ontario, Canada. 14. Faculty of Medicine, 25452Memorial University of Newfoundland-Grenfell Campus, Corner Brook, Newfoundland, Canada. 15. Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Abstract
STUDY PURPOSE: Morphometric methods categorize potential osteoporotic vertebral fractures (OVF) on the basis of loss of vertebral height. A particular example is the widely used semiquantitative morphometric tool proposed by Genant (GSQ). A newer morphologic algorithm-based qualitative (mABQ) tool focuses on vertebral end-plate damage in recognizing OVF. We used data from both sexes in the Canadian Multicentre Osteoporosis Study (CaMos) to compare the 2 methods in identifying OVF at baseline and during 10 years of follow-up. MATERIALS AND METHODS: We obtained lateral thoracic and lumbar spinal radiographs (T4-L4) 3 times, at 5-year intervals, in 828 participants of the population-based CaMos. Logistic regressions were used to study the association of 10-year changes in bone mineral density (BMD) with incident fractures. RESULTS: At baseline, 161 participants had grade 1 and 32 had grade 2 GSQ OVF; over the next 10 years, only 9 of these participants had sustained incident GSQ OVF. Contrastingly, 21 participants at baseline had grade 1 and 48 grade 2 mABQ events; over the next 10 years, 79 subjects experienced incident grade 1 or grade 2 mABQ events. Thus, incident grades 1 and 2 morphologic fractures were 8 times more common than morphometric deformities alone. Each 10-year decrease of 0.01 g/cm2 in total hip BMD was associated with a 4.1% (95% CI: 0.7-7.3) higher odds of having an incident vertebral fracture. CONCLUSIONS: This analysis further suggests that morphometric deformities and morphologic fractures constitute distinct entities; morphologic fractures conform more closely to the expected epidemiology of OVF.
STUDY PURPOSE: Morphometric methods categorize potential osteoporotic vertebral fractures (OVF) on the basis of loss of vertebral height. A particular example is the widely used semiquantitative morphometric tool proposed by Genant (GSQ). A newer morphologic algorithm-based qualitative (mABQ) tool focuses on vertebral end-plate damage in recognizing OVF. We used data from both sexes in the Canadian Multicentre Osteoporosis Study (CaMos) to compare the 2 methods in identifying OVF at baseline and during 10 years of follow-up. MATERIALS AND METHODS: We obtained lateral thoracic and lumbar spinal radiographs (T4-L4) 3 times, at 5-year intervals, in 828 participants of the population-based CaMos. Logistic regressions were used to study the association of 10-year changes in bone mineral density (BMD) with incident fractures. RESULTS: At baseline, 161 participants had grade 1 and 32 had grade 2 GSQ OVF; over the next 10 years, only 9 of these participants had sustained incident GSQ OVF. Contrastingly, 21 participants at baseline had grade 1 and 48 grade 2 mABQ events; over the next 10 years, 79 subjects experienced incident grade 1 or grade 2 mABQ events. Thus, incident grades 1 and 2 morphologic fractures were 8 times more common than morphometric deformities alone. Each 10-year decrease of 0.01 g/cm2 in total hip BMD was associated with a 4.1% (95% CI: 0.7-7.3) higher odds of having an incident vertebral fracture. CONCLUSIONS: This analysis further suggests that morphometric deformities and morphologic fractures constitute distinct entities; morphologic fractures conform more closely to the expected epidemiology of OVF.
Entities:
Keywords:
bone mineral density; gender differences; morphologic fractures; morphometric deformities; osteoporosis; vertebral fractures
Authors: Yì Xiáng J Wáng; Min Deng; James F Griffith; Anthony W L Kwok; Jason C S Leung; Patti M S Lam; Blanche Wai Man Yu; Ping Chung Leung; Timothy C Y Kwok Journal: Quant Imaging Med Surg Date: 2022-03