Daniel Possti1,2, Firas Fahoum3,4, Ronen Sosnik5, Nir Giladi1,2,3,4, Jeffrey M Hausdorff1,2,6,7, Anat Mirelman1,2,4, Inbal Maidan8,9,10. 1. Laboratory of Early Markers of Neurodegeneration, Center for the Study of Movement, Cognition, and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 64239, Tel Aviv, Israel. 2. Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel. 3. Epilepsy and EEG Unit, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. 4. Department of Neurology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. 5. Faculty of Electrical Engineering, Holon Institute of Technology (H.I.T.), Holon, Israel. 6. Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 7. Department of Orthopedic Surgery, Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA. 8. Laboratory of Early Markers of Neurodegeneration, Center for the Study of Movement, Cognition, and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 64239, Tel Aviv, Israel. inbalm@tlvmc.gov.il. 9. Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel. inbalm@tlvmc.gov.il. 10. Department of Neurology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. inbalm@tlvmc.gov.il.
Abstract
BACKGROUND: The ability to maintain adequate motor-cognitive performance under increasing task demands depends on the regulation and coordination of neural resources. Studies have shown that such resources diminish with aging and disease. EEG spectral analysis is a method that has the potential to provide insight into neural alterations affecting motor-cognitive performance. The aim of this study was to assess changes in spectral analysis during dual-task walking in aging and disease METHODS: 10 young adults, ten older adults, and ten patients with Parkinson's disease (PD) completed an auditory oddball task while standing and while walking on a treadmill. Spectral power within four frequency bandwidths, delta (< 4 Hz), theta (4-8 Hz), alpha (8-12 Hz), and beta (12-30 Hz), was calculated using Event-Related Spectral Perturbation (ERSP) analyses and compared between single task and dual task and between groups. RESULTS: Differences in ERSP were found in all groups between the single and dual-task conditions. In response to dual-task walking, beta increased in all groups (p < 0.026), delta decreased in young adults (p = 0.03) and patients with PD (0.015) while theta increased in young adults (p = 0.028) but decreased in older adults (p = 0.02) and patients with PD (p = 0.015). Differences were seen between the young, the older adults, and the patients with PD. CONCLUSIONS: These findings are the first to show changes in the power of different frequency bands during dual-task walking with aging and disease. These specific brain modulations may reflect deficits in readiness and allocation of attention that may be responsible for the deficits in dual-task performance.
BACKGROUND: The ability to maintain adequate motor-cognitive performance under increasing task demands depends on the regulation and coordination of neural resources. Studies have shown that such resources diminish with aging and disease. EEG spectral analysis is a method that has the potential to provide insight into neural alterations affecting motor-cognitive performance. The aim of this study was to assess changes in spectral analysis during dual-task walking in aging and disease METHODS: 10 young adults, ten older adults, and ten patients with Parkinson's disease (PD) completed an auditory oddball task while standing and while walking on a treadmill. Spectral power within four frequency bandwidths, delta (< 4 Hz), theta (4-8 Hz), alpha (8-12 Hz), and beta (12-30 Hz), was calculated using Event-Related Spectral Perturbation (ERSP) analyses and compared between single task and dual task and between groups. RESULTS: Differences in ERSP were found in all groups between the single and dual-task conditions. In response to dual-task walking, beta increased in all groups (p < 0.026), delta decreased in young adults (p = 0.03) and patients with PD (0.015) while theta increased in young adults (p = 0.028) but decreased in older adults (p = 0.02) and patients with PD (p = 0.015). Differences were seen between the young, the older adults, and the patients with PD. CONCLUSIONS: These findings are the first to show changes in the power of different frequency bands during dual-task walking with aging and disease. These specific brain modulations may reflect deficits in readiness and allocation of attention that may be responsible for the deficits in dual-task performance.
Authors: Chris Berka; Daniel J Levendowski; Michelle N Lumicao; Alan Yau; Gene Davis; Vladimir T Zivkovic; Richard E Olmstead; Patrice D Tremoulet; Patrick L Craven Journal: Aviat Space Environ Med Date: 2007-05
Authors: Hannes Devos; Kathleen Gustafson; Ke Liao; Pedram Ahmadnezhad; Bradley Estes; Laura E Martin; Jonathan D Mahnken; William M Brooks; Jeffrey M Burns Journal: Transl Neurodegener Date: 2022-02-09 Impact factor: 8.014