Recent Advances in Synthesis and Properties of Nitrated-Pyrazoles Based Energetic Compounds.

Nitrated-pyrazole-based energetic compounds have attracted wide publicity in the field of energetic materials (EMs) due to their high heat of formation, high density, tailored thermal stability, and detonation performance. Many nitrated-pyrazole-based energetic compounds have been developed to meet the increasing demands of high power, low sensitivity, and eco-friendly environment, and they have good applications in explosives, propellants, and pyrotechnics. Continuous and growing efforts have been committed to promote the rapid development of nitrated-pyrazole-based EMs in the last decade, especially through large amounts of Chinese research. Some of the ultimate aims of nitrated-pyrazole-based materials are to develop potential candidates of castable explosives, explore novel insensitive high energy materials, search for low cost synthesis strategies, high efficiency, and green environmental protection, and further widen the applications of EMs. This review article aims to present the recent processes in the synthesis and physical and explosive performances of the nitrated-pyrazole-based Ems, including monopyrazoles with nitro, bispyrazoles with nitro, nitropyrazolo[4,3-c]pyrazoles, and their derivatives, and to comb the development trend of these compounds. This review intends to prompt fresh concepts for designing prominent high-performance nitropyrazole-based EMs.

1. Introduction

Energetic materials (EMs), including explosives, propellants, and pyrotechnics, are a significant class of compounds containing large amounts of stored chemical energy, which can liberate heat and exert high pressure under some stimuli, like impact, shock, or thermal effect [1,2,3,4,5,6,7,8]. With the development of science and technology, more and more attention has been paid to the high energy density materials (HEDMs) used for energy and as explosives or propellants [9]. Thus, the representatives of traditional HEDMs are 2,4,6-trinitrotoluene (TNT) [10,11], 1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) [12,13], 1,3,5-trinitro-1,3,5-triazine (RDX) [14], triaminotrinitrobenzene (TATB) [15], and 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) [16]. The key properties for HEDMs include density (ρ), melting point (Tm), decomposition temperature (Td), heat of formation (HOF), calculated detonation velocity (D, calculated propagation velocity of detonation wave in explosive grain), calculated detonation pressure (P, calculated pressure on the front of detonation wave), oxygen balance (OB, residual amount of oxygen when explosive explodes to produce CO2 and H2O, OB = 16[c-(2a + b/2)]/M for molecule CaHbOcNd), specific impulse (Isp, impulse produced by the unit quantity of propellant), content of nitrogen (N), impact sensitivity (IS, sensitivity of explosive to impact), friction sensitivity (FS, sensitivity of explosive to friction), electrostatic discharge sensitivity (ESD), and sensitivity of explosive to electrostatic discharge, etc. There are several standards a novel HEDM should meet if it would be applied widely, including insensitivity toward mechanical stimuli (heat, impact, fraction, and electrostatic discharge) to ensure the safety of operation, high performance for various purposes, less toxicity, and producing less hazardous waste after detonation [17,18,19]. Among them, conflict between the increasing energetic level and decreasing sensitivity has become more and more severe. Therefore, the exploration and development of high energy density compounds with low sensitivity have been a priority. A significant amount of effort has been made to resolve this problem, such as recrystallization of Ems [20], preparing polymer bonded explosives (PBXs) [21,22], forming energetic cocrystals [23,24,25], and synthesizing novel energetic compounds [26,27,28,29]. In contrast with other technologies, synthesizing new HEDMs may be the most direct and effective method.

Nitrogen heterocyclic energetic materials that have large numbers of N–N bonds and C–N bonds with high energy can form the large π bond similar to benzene, which endows this kind of compounds low sensitivity, high positive heat of formation, and good thermal stability. In addition, the low percentage of C and N in these compounds always lead to high density and good oxygen balance. The decomposition of these compounds can result in the N2, which is environmentally friendly [30]. There is a big difference between nitrogen-rich energetic compounds and traditional explosives, namely the energy of nitrogen heterocyclic compounds is released from the high positive heat of formation rather than the oxidation of carbon backbone like traditional explosive (such as TNT and TATB) [19,31]. Therefore, nitrogen heterocyclic materials have garnered large interest in the research areas of HEDMs.

As an outstanding representative of nitrogen heterocyclic compounds, nitropyrazoles and their derivatives are aromatic stable substances with π electrons in their structures. The system is easy to carry out electrophilic substitution reactions such as nitration, sulfonation and halogenation, etc. [32]. These compounds are characterized by oxidation resistance, heat resistance and hydrolysis resistance [19], and are widely applied in civil fields, such as medicine, pesticide, photosensitive materials, and fine chemicals [33,34,35]. Due to the compactness, stability, and modifiability of the molecular structure of pyrazoles, nitration and derivatization of pyrazoles are relatively easy. The ring tension in the structures of nitropyrazoles and their derivatives is large. The density and nitrogen content of nitropyrazoles increase with the presence of nitro groups on the ring, and the oxygen balance is closer to the ideal value, which can improve the detonation performance of the target compounds. Many energetic compounds based on nitropyrazoles have been synthesized successively, which have good applications in highly energy insensitive explosives, propellants, pyrotechnic agents, and other fields [2,3,19,36,37].

In the past decade, a lot of papers on the synthesis and properties of nitrated pyrazoles have been published, including many Chinese references which are not accessible for most Western researchers due to language barriers. This review article presents the recent processes in synthesis, physical and explosive performances of the nitropyrazole-based Ems, including monopyrazoles with nitro, bispyrazoles with nitro, nitropyrazolopyrazoles and their derivatives, and to comb the development trend of these compounds. The aim of this review is to provide readers with an overview of the relationship between structures and properties and guide the future design of novel HEDMs. This review also intends to prompt fresh concepts for designing prominent high-performances nitropyrazole-based EMs.

2. Nitrated-Monopyrazole Based Compounds

In this section, the sum of nitro group substituted on carbon position of pyrazole ring in mononitropyrazoles, binitropyrazoles, and trinitropyrazoles are one, two, and three, respectively. For example, mononitropyrazole represents that only one C position in pyrazole ring is substituted by the nitro group.

2.1. Mononitropyrazoles and Their Derivatives

Mononitropyrazoles and their derivatives due to their energetic property are favored by people in many fields, such as medicine, pesticide, energetic material and so on. Among them, 3-nitropyrazole (3-NP), 4-nitropyrazole (4-NP), 1-methyl-3-nitropyrazole (3-MNP), and 1-methyl-4-nitropyrazole (4MNP) are typical examples, which are commonly used as energetic materials and intermediates for further products of other energetic materials because they contain only one nitro group and have relatively low energy. The syntheses of these compounds is often facile and can meet the development requirements of green chemistry.

As a typical heterocyclic compound, 3-NP is an important intermediate in the synthesis of pyrazole-based compounds such as 3,4-dinitropyrazole (DNP) and other new explosives [36,38]. In 1970, Habraken and co-authors [39] firstly reported synthesis of 3-NP by dissolving N-nitropyrazole in anisole for 10 h at 145 °C. Later, Verbruggen et al. [40] synthesized 3-NP from diazomethane and chloronitroethylene by one-step cyclization, while this reaction was high riskful due to the extremely vivacious raw materials. Nowadays, the main synthesis method of 3-NP was a two-step reaction, that is, nitration of pyrazole to obtain N-nitropyrazole and then rearrangement of N-nitropyrazole in organic solvent to acquire 3-NP (Figure 1, Scheme A). The nitration agents could be HNO3/H2SO4 or HNO3/Ac2O/HAc, and the organic solvent for rearrangement could be anisole, n-octanol and benzonitrile [41,42,43]. Among these solvents, benzonitrile was always preferred to be the rearrangement medium since anisole could require an excessively long time and n-octanol would lead to poor-quality product. In 2014, Zhao et al. [44] reported one convenient and green approach to synthesizing the 3-NP. They chose the oxone as the nitration agents of 3-aminopyrazole and water as the solvent (Figure 1, Scheme B). This approach owns some advantages over the previous approach: simple operation, safety, economical reagents, the use of water as solvent, and mild conditions. As shown in Figure 1, 3-MNP is one of the most important derivatives of 3-NP. Its synthesis is mainly accomplished by nitrated 1-methylpyrazole with various nitration agents. Katritzky et al. [45] added 1-methylpyrazole to trifluoroacetic anhydride for 1 h in ice bath, and then concentrated nitric acid was added in the solution. After stirring for 12 h, and evaporation of trifluoroacetic anhydride and nitric acid, the 3-MNP could be obtained (Figure 1, Scheme C). In 2013, Ravi et al. [46] proposed that 1-methylpyrazole could reacted with silicon oxide-bismuth nitrate or silicon dioxide-sulfuric acid-bismuth nitrate in tetrahydrofuran (THF) to produce 3-MNP (Figure 1, Scheme D), this facile route is a synthetic method of low toxicity, high efficiency, and green environmental protection. In addition, metal salts of 3-NP expand its derivatives. Li et al. [42] prepared the metal Cu(II) salt and basic Pb salt of 3-NP, by dissolving 3-NP in NaOH solution and reacting with the CuSO4·5H2O solution and Pb(NO3)2 solution, respectively (Figure 1, Scheme E).

Figure 1

Summary of synthesis of 3-NP, 3-MNP and metal salts of 3-NP.

4-NP is an isomer of 3-NP with melting point of 163–165 °C, density of 1.52 g/cm3, detonation velocity of 6.68 km/s and detonation pressure of 18.81 Gpa [47]. Similar to 3-NP, 4-NP can be obtained by nitro group rearrangement. As Rao et al. [48] reported N-nitropyrazole could be rearranged to 4-NP in sulfuric acid at room temperature (Figure 2, Scheme A). Ravi et al. [49] synthesized 4-NP in THF with 4-iodopyrazole as raw material, fuming HNO3 as nitration agents, octahedral zeolite or silica as solid catalyst (Figure 2, Scheme B). Li et al. [50] reported one-pot two steps route that pyrazole could be nitrated to 4-NP by fuming HNO3 (90%)/fuming H2SO4 (20%) (Figure 2, Scheme C). 4-MNP is another important derivative of nitropyrazole with the similar performance to 3-MNP (Table 1). In 2015, Corte et al. [51] reported that 4-MNP could be synthesized by adding sodium hydride and iodomethane into the THF solution of 4-NP at room temperature for overnight. Ioannidis et al. [52] improved the method by adding sodium hydride and iodomethane to the acetonitrile solution of 4-NP under nitrogen protection for 16 h. However, it is dangerous to handle sodium hydride due to its high chemical reaction activity which can easily cause combustion and explosion, limiting the further application of this method. Han et al. [53] simplified the above method and replaced sodium hydride with potassium carbonate. They added potassium carbonate and iodomethane to the N,N-dimethylformamide (DMF) solution of 4-NP at 25 °C for 14 h. This method not only reduces the risk in the process, but improves the reaction yield (80–98%).

Figure 2

Synthesis of 4-NP.

Table 1

Properties of 3-NP, 4-NP, 3-MNP and 4-MNP.

Explosive	ρ/g·cm−3	D/km·s−1	P/GPa	Tm/°C	OB/%	N/%	Ref.
3-NP	1.57	7.02	20.08	174–175	−77.88	37.17	[55]
4-NP	1.52	6.86	18.81	163–165	−77.88	37.17	[55]
3-MNP	1.47	6.62	17.11	80–83	−107.09	26.77	[3]
4-MNP	1.40	6.42	15.52	82	−107.09	26.77	[3]

Table 1 shows the energetic performances of the four typical monopyrazoles. We can see that these energetic performances of pyrazole-based compounds are not satisfying, especially the detonation properties and the nitrogen content. So, these nitropyrazoles are always used as intermediates for the preparation of novel high-performance energetic materials. Furthermore, it is also necessary to explore new high performances energetic materials based on mononitropyrazoles. For example, Deng et al. [54] prepared 5-methyl-4-nitro-1H-pyrazol-3(2H)-one (MNPO) and its energetic salts, showing better performances than these above mononitropyrazoles.

The introduction of a polynitromethyl group into a heterocyclic compound is interesting for energetic field, because it can increase the oxygen content and improve the energetic properties of energetic material. Generally, the incorporation of a polynitromethyl group (trinitromethyl and dinitromethyl) to nitropyrazoles is essentially equivalent to introducing at least one -NO2 (since one -NO2 is used for the complete oxidation of the C atom in -CH3) [56]. For the trinitromethyl group, it can be incorporated into N position or C position of nitropyrazoles with different energetic properties. The N-H bond of nitropyrazole is relatively active which could provide a reaction site for functionalization easily. In 2014, Yin et al. [57] obtained the carbon and nitrogen functionalization of nitropyrazole with N-trinitroethylamino group (Figure 3, Scheme A). Thereby, 4-NP reacted with NH2OSO3H acid and K2CO3 to accomplish amination, and after functionalization of amino group, the 1-amino-4-nitropyrazole underwent the Mannich reaction with trinitroethanol to get 4-nitro-N-(2,2,2-trinitroethyl)-1H-pyrazol-1-amine (1). In 2015, Dalinger et al. [58] prepared and characterized a nitropyrazole bearing a trinitromethyl moiety at N atom, 4-nitro-1-(trinitromethyl)-pyrazoles (2). They synthesized the target compound by a destructive nitration of 4-nitro-1-acetonpyrazole with a mixture of concentrated HNO3 and H2SO4 (Figure 3, Scheme B). Although the compound 1 was successfully synthesized, the yield was very low (28%) and this process was comparatively too time-consuming (15 d). To explore new high-performance EM, several C-trinitromethyl-substituted mononitropyrazoles have been reported. In 2018, Zhang and co-authors [56] first synthesized the C-trinitromethyl-substituted nitropyrazole (Figure 4, Scheme A). The reaction of 3-pyrazolecarbaldehyde oxime with N2O4 produced the 3-trinitromethylpyrazole and 1-nitro-3-trinitromethylpyrazole (3). They found that the increasing N2O4 concentration could improve the proportion of 3 and 3-trinitromethylpyrazole reacting with N2O4 also form 3, indicating N2O4 enable nitrate the N position of pyrazole. After the introduction of trinitromethyl group on C position, the 4-nitro-3-trinitromethylpyrazole (4) could be obtained with fuming nitric acid and oleum by -NO2 rearrangement of 3 or nitration of 3-trinitromethylpyrazole. In 2019, Xiong et al. [59] further designed 3-Trinitromethyl-4-nitro-5-nitramine-1H-pyrazole (5). It was notable that the yield of 5 could improve with the concentration of HNO3 increasing in the last nitration step of Scheme B (Figure 4). For the dinitromethyl group, Semenov et al. [60] prepared the 4-nitro-1-dinitromethylpyrazole by nitrating 4-nitro-1-acetonylpyrazole using H2SO4/H2O mixture, and while the yield was low and it was not investigated as energetic material. In 2019, Pang et al. [61] introduced the dinitromethyl group into nitropyrazole and developed the salt, hydrazinium 5-nitro-3-dinitromethyl-2H-pyrazole (6), according to Scheme A in Figure 5. In 2020, Cheng et al. [62] synthesized 3-nitro-4-dinitromethyl-2H-pyrazole (7) and its salts, further exploring the application of dinitromethyl group in mononitropyrazolle. Table 2 shows the energetic properties of the polynitromethyl-substituted mononitropyrazoles and salts compared with TNT and RDX. All the density of the derivatives of mononitropyrazole was higher than TNT and close to that of RDX, especially 7a showed the highest density. 3 and 5 owned the desirable detonation properties, while exhibited poor safety. It was notable that C-trinitromethyl-substituted derivatives owned higher heat of formation than those of N-trinitromethyl-substituted derivatives, and the derivatives with dinitromethyl group owned lower heat of formation than derivatives with trinitromethyl group. Most of the neutral derivatives hold low decomposition temperatures owing to the instability of the polynitromethyl moiety. Compound 4 had the highest decomposition temperature possibly because of the strong intermolecular hydrogen bonding interactions. By comparing 4 and 5, we can see the nitramino group could further increase the power with low sensitivities. For the salts of compound 7, 7d with high detonation properties (comparing with RDX) and low sensitivities could serve as a promising candidate as a new high energy density oxidizer.

Figure 3

Synthesis of compounds 1 and 2.

Figure 4

Synthesis of compounds 3–5.

Figure 5

Synthesis of salts of trinitromethyl and dinitromethyl-substituted mononitropyrazoles.

Table 2

Properties of the derivatives of compounds 1–7.

Entry	ρ/g·cm−3	D/km·s−1	P/GPa	Tm/°C	Td/°C	OB/%	N/%	HOF/kJ ·mol−1	IS/J	FS/N	Ref.
1	1.74	8.39	30.8	109.0	112	+2.75	33.68	140.9	15.0	360	[57]
2	1.80	8.65	33.9	39.0	145	−6.10	32.07	181.0	7.5	120	[58]
3	1.85	8.93	35.9	59.9	113	+18.3	32.07	311.4	2.5	36	[56]
4	1.80	8.60	32.2	147.2	154	+18.3	32.07	208.1	3.0	80	[56]
5	1.90	9.12	37.2	74	124	+24.8	34.79	320.2	5.0	80	[59]
6	1.84	8.79	33.8	-	128	−9.64	39.35	194.8	7.0	192	[61]
7	1.76	8.53	30.8	-	117	−25.79	32.26	205.6	17.0	114	[62]
7a	2.01	8.13	29.5	-	171	−21.94	27.44	−55.7	4.0	36	[62]
7b	1.87	8.26	28.6	-	203	−23.42	29.29	28.2	9.0	120	[62]
7c	1.78	8.60	33.0	-	141	−34.16	35.90	85.4	>20.0	192	[62]
7d	1.80	8.70	34.1	-	166	−24.20	33.60	135.5	>20.0	162	[62]
7e	1.72	8.26	28.7	-	161	−46.37	40.58	43.8	>20.0	240	[62]
7f	1.71	8.48	30.1	-	140	−46.74	43.29	231.4	>20.0	252	[62]
TNT	1.65	6.88	19.5	80. 5	295	−73.8	18.49	−67.0	15.0	358	[62]
RDX	1.80	8.75	34.9	204.1	210	−21.6	37.82	70.0	7.0	120	[62]

Connecting nitropyrazoles with nitrogen-rich compounds (including tetrazole, triazole, furazan, tetrazine, triazine, and others) has attracted more interest in many fields, it also be an effective approach to increasing the content of nitrogen and getting new high-performance energetic materials. In 2015, Yin et al. [63] synthesized energetic salts based on N-methyl 6-nitropyrazolo[3,4-d][1,2,3]triazol-3(4H)-olate in a similar manner exhibiting good detonation performance with relatively low sensitivities. In 2016, Dalinger et al. [64] synthesized and investigated systematically a series of 1- and 5-(pyrazolyl)tetrazole amino and nitro derivatives which could be components of dyes and luminophores, and high-energy materials. Some of them were always used as intermediates due to their poor energetic properties. In 2017, Zyuzin et al. [65] introduced the 2,2-bis(methoxy-NNO-azoxy)ethyl group to nitropyrazoles to increase the hydrogen content for some special application (gun propellants, solid rocket propellants and others). The derivatives of 3-NP and 4-NP showed high heat of formation, while the oxygen balances and calculated detonation velocity were not ideal. Then, Zyuzin et al. [66] further introduced the trinitromethyl moiety owning the most oxygen-rich block into the combination of tetrazole and pyrazole rings to obtain oxygen-balanced energetic materials with high nitrogen content (8–11) (Figure 6). In 2019, Tang et al. [67] developed several compounds and salts based 3,5-diamino-4-nitropyrazole functionalizing the with tetrazole group and triazine group (12–15) (Figure 7). As shown in Table 3, all the compounds had high density, high nitrogen content and good detonation properties, while the thermal stability of 12–15 was better than that of 8–11. In particular, the derivatives 12–15 showed excellent insensitivities. In addition, most compounds owned positive and high heat of formation, but the presence of water molecules in 13a result in its negative heat of formation. Considering the low sensitivities, good detonation properties, and high thermal stabilities, these derivatives with nitrogen-rich groups may be the candidates of insensitive high energetic materials.

Figure 6

Synthesis of mononitropyrazole derivatives 8–11.

Figure 7

Synthesis of mononitropyrazole derivatives 12–15.

Table 3

Energetic characteristics of compounds 8–15. The data of compounds 8–11 are from reference [66], the data of compounds 12–15 are from reference [67].

Entry	ρ/g·cm−3	D/km·s−1	P/GPa	Td/°C	N/%	HOF/kJ· mol−1	IS/J	FS/N
8	1.79	8.86	34	127	42.43	602	-	-
9	1.81	8.47	31	111	41.59	386	-	-
10	1.91	8.99	36	138	41.67	589	-	-
11	1.76	8.78	32	132	42.43	629	-	-
12	1.76	8.26	25.9	272	59.70	408	30	360
12a	1.78	8.82	29.9	187	56.89	445	32	360
12b	1.75	8.80	28.9	229	63.36	547	35	>360
12c	1.70	8.29	24.9	251	61.39	399	40	>360
12d	1.69	8.24	23.9	224	63.84	486	40	>360
12e	1.72	8.14	23.6	287	63.21	338	40	>360
13	1.72	8.00	22.8	200	52.96	127.6	>40	>360
13a	1.68	8.00	23.8	196	45.15	−483.3	32	360
14	1.75	8.81	32.6	148	47.94	462.8	30	360
15	1.78	7.79	21.8	406	53.52	127.1	>40	>360

Moreover, nitrogen-rich heterocycles with a nitramino moiety could exhibit better performance than the corresponding nitro-substituted analogs as above mentioned [59,68]. In 2019, Shreeve and her group [69] reported a green synthetic route for high-performance nitramino nitropyrazoles. Figure 8 depicted the synthesis of corresponding derivatives, among them the 3,5-dinitramino-4-nitropyrazole (16) was quite sensitive to mechanical stimulation. From Table 4, the compound 16b showed promising properties with a high density (1.87 g·cm−3), good detonation properties (D of 9.58 km·s−1 and P of 38.5 GPa), decomposition temperature of 194 °C, and acceptable sensitivities. Xu et al. [70] introduced nitramino and triazole groups into mononitropyrazole to construct multiple hydrogen bonds (17), and synthesized the 4-nitro-3,5-bis(1H-1,2,4-triazol-3-nitramino)-1H-pyrazole (19) and its ionic derivatives (19a–i) as shown in Figure 9. Table 4 also showed their energetic properties. Compound 17 had the highest decomposition temperature (353.6 °C) and excellent low sensitivity (IS > 40, FS > 360), indicating it could be used as heat-resistant insensitive explosive. The compounds (18–19i) exhibited moderate detonation properties, high positive heat of formation and ideal insensitivities which had great potential application in green and safe energetic materials. Ma et al. [71] also fused nitropyrazole with triazine and nitramino groups, and prepared a series of salts based on compounds 20 and 21 (Figure 10). These compounds owned high thermal stability and excellent insensitive properties because of the existence of triazine ring.

Figure 8

Synthesis of compound 16 and its salts.

Table 4

Energetic characteristics of compounds 16a–21d. The data of compounds 16a–d are from reference [69], the data of compounds 17–19i are from reference [70], the data of compounds 20a·H2O –21d·H2O are from reference [71].

Entry	ρ/g·cm−3	D/km·s−1	P/GPa	Td/°C	HOF/kJ· mol−1	IS/J	FS/N
16a	1.90	9.39	40.0	155.0	74	6	120
16b	1.87	9.58	38.5	194.0	266	12	160
16c	1.80	8.84	32.6	192.0	−20	15	240
16d	2.12	7.64	26.4	232.0	246	2	120
17	1.77	8.24	23.1	353.6	555.0	>40	>360
18	1.87	8.75	33.0	238.2	737.6	30	360
19	1.92	9.01	35.9	134.4	791.8	20	270
19a	1.76	8.68	30.0	186.6	711.4	>40	>360
19b	1.79	9.08	33.6	171.3	842.0	>40	>360
19c	1.73	8.76	30.2	186.6	1062.4	>40	>360
19d	1.71	8.19	25.1	195.4	677.9	>40	>360
19e	1.71	8.50	27.3	191.3	1068.7	>40	>360
19f	1.75	8.71	29.7	208.2	1014.6	22.4	>360
19g	1.72	8.12	25.7	168.5	1300.5	>40	>360
19h	1.74	8.16	26.0	189.7	1270.5	>40	>360
19i	1.72	8.14	25.9	175.9	1511.2	>40	>360
20a	1.82	8.39	28.2	180.0	60.0	>40	360
20b	1.83	8.10	28.0	279.0	105.0	40	240
21	1.89	8.71	31.9	248.0	314.6	>40	>360
21a·H2O	1.95	8.29	29.1	341.0	260.9	>40	>360
21b·H2O	1.81	8.98	32.1	218.0	386.2	>40	>360
21c·H2O	1.80	9.06	31.7	190.0	557.5	>40	>360
21d·H2O	1.60	8.22	24.6	223.0	690.0	>40	>360

Figure 9

Synthesis of compounds 17–19i.

Figure 10

Synthesis of compounds 20a–21d.

In summary, most of mononitropyrazoles and their derivatives owned relatively low thermal properties and detonation properties. They are always used as intermediates for novel complicated energetic materials. The introduction of polynitromethyl group can improve the oxygen balance efficiently, while have a little influence on the heats of formation. The nitramino group and nitrogen-rich heterocyclic can enhance the detonation properties, improve the safety, and increase the heats of formation of mononitropyrazoles. The choice of solvent and nitrification in synthesis routes should be more environmental and facile.

2.2. Dinitropyrazoles and Their Derivatives

Dinitropyrazoles own higher density and better detonation performance than mononitropyrazoles attributing to one more nitro group. The typical dinitropyrazoles include 3,4-dinitropyrazole (3,4-DNP), 3,5-dinitropyrazole (3,5-DNP), 1-methyl-3,4-dinitropyrazole (3,4-MDNP), 1-methyl-3,5-dinitropyrazole (3,5-MDNP), and 4-amino-3,5-dinitropyrazole (LLM-116).

3,4-DNP is a kind of white crystal, possessing higher density (1.87 g·cm−3), lower melting point (86–88 °C), higher decomposition temperature (285 °C), higher detonation velocity (8.1 km·s−1) and detonation pressure (29.4 GPa) than TNT. This compound was first reported by Biffin’s team in 1966 [72]. In an earlier study, pyrazole, 4-NP, 3-nitro-4-cyanopyrazole and other raw materials have been investigated to prepare 3,4-DNP, while most of the methods did not satisfied industrialization due to complex process, high production cost or low yield [45,55,73,74,75,76]. At present, the three-step synthetic route as shown in Figure 11 (Scheme A), and the two-step route (Scheme B) are the most widely used [77,78,79,80]. 3,4-MDNP is a typical thermal stability nitropyrazole, exhibiting stable thermodynamic state at 300 °C. Its melting point and density are lower than those of 3,4-DNP (20–23 °C, 1.67 g·cm−3), and 3,4-DNP shows low detonation velocity (7.76 km s−1) and detonation pressure (25.57 GPa) due to the introduction of methyl group. It has potential application in liquid explosive, which can reduce the melting point of liquid phase carrier in castable explosive [32]. Recently, Ravi et al. [73] had synthesized 3,4-MDNP by nitrating 1-methylpyrazole or 1-methyl-3-nitropyrazole with montmorillonite (K-10) and Bi(NO3)3, while this method was high cost and the products were difficult to separate. Li et al. [81] reacted 3,4-DNP and dimethyl carbonate (DMC) in DMF with K2CO3 as catalyst, then, his group further synthesized 3,4-MDPN with 3-NP as raw material (Figure 11, Scheme C) [82]. In this method, DMC was used as methylation agent and the yield of methylation was high (95.6%), which could meet the requirement of green chemistry. As 3,5-DNP with a melting point of 173–174 °C and density of 1.80 g·cm−3, the decomposition temperature of 316.8 °C owns higher detonation properties than 3,4-DNP (7.76 km·−1 and 25.57 GPa). Moreover, 3,5-DNP is relatively stable because of the symmetrical molecular distribution, it can be used as a simple explosive or as a key intermediate in the synthesis of insensitive explosives [55]. Generally, the starting materials for preparing 3,5-DNP could be pyrazole and 3-NP. Wang et al. [83] nitrated 3-NP to get 1,3-dinitropyrazole, then 1,3-dinitropyrazole was reacted with NH3 in PhCN to produce the ammonium salt of 3,5-DNP. After neutralization with hydrochloric acid, the 3,5-DNP could be obtained (Figure 12, Scheme A). Liu et al. [28] also nitrated 3-NP, and rearranged 1,3-dinitropyrazole to get 3,5-DNP (Figure 12, Scheme B). For pyrazole as starting material, 3,5-DNP was always prepared by a four-step route (nitration of pyrazole, rearrangement of N-nitropyrazole, nitration of 3-NP, and rearrangement of 1,3-dinitropyrazole). 3,5-MDNP owns the similar energetic properties with 3,4-MDNP, while it has a higher melting point (about 60 °C). Moreover, 3,5-MDNP could be synthesized by methylation of 3,5-DNP [84]. However, most methylation agents were extremely toxic, thus searching for a green methylation agent would be the key factor.

Figure 11

Synthesis of 3,4-DNP and 3,4-MDNP.

Figure 12

Synthesis of 3,5-DNP and 3,5-MDNP.

LLM-116 is a powerful and insensitive explosive, its energy is 90% of HMX and its impact sensitivity is extremely low [55,85]. It was first synthesized by the Lawrence Livermore National Laboratory (LLNL) in 2001, and many studies were performed to assess its synthesis in the following years. Wang et al. [86] utilized vicarious nucleophilic substitution (VNS) of 3,5-DNP and trimethylhydrazine iodideto (TMHI) to prepare LLM-116 with a yield of 60%, while the toxic TMHI was the main factors restricting wide application of this method. In 2014, Stefan et al. [87] developed four synthetic routes of LLM-116, using 4-NP, 3,5-dimethylpyrazole, 3,5-DNP and 4-chloropyrazole as starting materials, respectively (Figure 13, Scheme A–D). Table 5 shows the comparison of the four routes. The synthesis of Scheme D was simple and its yield was high, which was suitable for industrialization. Zhang et al. [88] also used 4-chloropyrazole as a starting material to synthesize LLM-116 with an overall yield of 65%.

Figure 13

Synthesis of LLM-116.

Table 5

A brief comparison of four routes by Stefan.

Via 4-NP (Method A)	Via 3,5-Dimethylpyrazole (Method B)	Via 3,5-DNP (Method C)	Via 4-Chloropyrazole (Method D)
Four steps	Six steps	Five steps	Two steps
Moderate amount of waste	High amount of waste	Moderate amount of waste	Small amount of waste
No unfavorable solvents required	No unfavorable solvents required	DMSO used in the last step	No unfavorable solvents required
Moderate overall yield, 40%	Moderate overall yield, 37%	Low overall yield, 21%	Moderate overall yield, 61%
Average yield/step: 80%	Average yield/step: 85%	Average yield/step: 73%	Average yield/step: 78%

In addition, 4-Chloro-3,5-dinitropyrazole was a useful intermediate in the preparation of various 3,5-DNP [89], owning good reactivity towards nucleophiles. He et al. [90] synthesized a series of 3,5-DNP derivatives based on 4-chloro-3,5-dinitropyrazole and 1-methyl-4-chloro-3,5-dinitropyrazole shown in Figure 14. From Table 6, all compounds exhibited better detonation properties than those of TNT, and these compounds owned better IS than RDX except compound 33. Compounds 26 and 28 had an especially good balance between physical properties and detonation properties as well as excellent insensitivity, making them potential replacement of RDX.

Figure 14

Synthesis of derivatives based on 4-amino-3,5-dinitropyrazole and 1-methyl-4-chloro-3,5-dinitropyrazole.

Table 6

Physical and detonation properties of compounds 22–35. The data of compounds 22–35 are from reference [90].

Entry	ρ/g·cm−3	D/km·s−1	P/GPa	Td/°C	HOF/kJ· mol−1	IS/J
22	1.74	8.22	30.1	178	137.0	17
23	1.69	8.25	28.7	176	104.6	35
24	1.72	8.31	30.2	176	220.7	18
25	1.63	8.14	26.3	275	64.8	>60
26	1.88	8.73	35.0	241	166.0	>40
27	1.66	7.82	23.4	245	133.5	>40
28	1.84	8.46	31.0	308	182.6	>40
29	1.78	8.39	31.4	233	236.6	10
30	1.74	8.41	31.0	161	436.0	14
31	1.63	7.42	21.7	228	177.0	22
32	1.71	8.72	30.9	146	549.6	8
33	1.70	8.18	27.6	101	414.4	6
34	1.67	7.80	24.6	270	64.5	>40
35	1.78	8.25	31.2	285	109.1	>40

Energetic salts often possess superior properties comparing with non-ionic species since they always show lower vapor pressures, lower impact and friction sensitivities, and enhanced thermal stabilities [19]. In addition to the derivatives mentioned above, Klapötke group [26] developed the ionic salts of 3,4-DNP and 3,5-DNP shown in Figure 15, and these salts were extremely insensitive in Table 7. Comparing with 3,4-DNP, 36 and 38 owned much lower decomposition temperatures, similar to that of 37, 39 and 3,5-DNP. Zhang et al. [91] developed the ionic salts of LLM-116 with several nitrogen-rich cations as shown in Figure 16. These compounds showed extraordinary insensitivity to impact (>60 J), as the detonation properties of 40i and 41k were comparable to those of TATB (31.15 GPa, 8.11 km·s−1) (Table 7).

Figure 15

Synthesis of ionic salts of 3,4-DNP and 3,5-DNP.

Table 7

Physical and detonation properties of ionic salts of dinitropyrazoles. The data of compounds 36–39 are from reference [26], the data of compounds 40a–41o and TATB are from reference [91].

Entry	ρ/g·cm−3	D/km·s−1	P/GPa	Td/°C	HOF/kJ· mol−1	IS/J	FS/N
36	1.69	-	-	127	-	40	360
37	1.70	8.11	25.9	300	-	40	360
38	1.63	7.59	21.1	156	-	40	360
39	1.59	7.32	19.1	295	-	40	360
40a	1.63	8.14	26.3	275	64.8	>60	-
40b	1.64	8.19	26.4	221	222.6	>60	-
40c	1.63	7.72	21.6	303	36.1	>60	-
40d	1.69	8.24	25.2	223	140.1	>60	-
40e	1.62	7.44	22.7	179	310.4	>60	-
40f	1.67	7.73	22.4	257	283.6	>60	-
40g	1.73	8.12	25.8	223	411.1	>60	-
40h	1.79	8.42	27.2	270	241.6	>60	-
40i	1.84	8.74	32.6	193	211.9	>60	-
41j	1.67	8.35	25.9	201	250.5	>60	-
41k	1.71	8.75	28.9	229	356.9	>60	-
41l	1.72	7.98	24.2	169	100.4	>60	-
41m	1.73	7.94	23.1	243	−166.3	>60	-
41n	1.54	7.71	21.0	206	389.3	>60	-
41o	1.60	7.78	22.4	173	471.8	>60	-
TATB	1.93	8.11	31.2	324	−140.0	50	-

Figure 16

Synthesis of ionic salts of LLM-116.

N-oxidation of nitrogen-rich heterocycles including transformation of amino group to nitroso, azoxy, or nitro groups is another approach to designing HEDMs, which opens new avenues for the development of HEDMs [92,93]. The efforts to developing N-oxidation of dinitropyrazoles have been made recently. Bölter et al. [94] introduced -OH on N atom of 3,4-DNP and 3,5-DNP, and obtained several salts (Figure 17, Scheme A). From Table 8, these compounds were less sensitive than RDX, and did not exhibited excellent detonation properties. Yin et al. [95] synthesized a family of 4-amino-3,5-dinitro-1H-pyrazol-1-ol (44) and its ionic derivatives (44a–f) (Figure 17, Scheme B). Except 44·H2O, all the compounds (44a–f, and 45) with thermal decomposition temperatures (169–216 °C) shown good balance between detonation properties and insensitive properties as shown in Table 8. Zhang et al. [96] synthesized the 4-nitramino-3,5-dinitropyrazole by nitrating the -NH2 of LLM-116, and prepared several energetic salts which exhibited good insensitivity and moderate detonation properties.

Figure 17

Synthesis of ionic salts of dinitropyrazoles.

Table 8

Physical and computational properties of ionic salts of dinitropyrazoles. The data of compounds 42a–43d are from reference [94], the data of compounds 44·H2O–45 are from reference [95].

Entry	ρ/g·cm−3	D/km·s−1	P/GPa	Td/°C	IS/J	FS/N
42a	1.96	7.92	26.9	197	5	216
42b	1.68	8.28	28.2	167	10	360
42c	1.70	8.06	25.1	180	30	360
42d	1.64	8.02	24.7	169	10	360
43a	-	-	-	229	6	240
43b	1.62	7.91	24.4	224	30	288
43c	1.68	7.94	24.2	266	40	360
43d	1.68	8.16	25.7	131	10	360
44·H2O	1.86	-	-	93	20	240
44a	1.79	8.94	34.4	216	25	240
44b	1.86	9.00	37.6	182	35	360
44c	1.84	8.80	34.0	175	40	360
44d	1.71	8.20	26.4	204	40	360
44e	1.71	8.54	28.0	169	40	360
44f	175	8.88	30.7	214	40	360
45	1.80	8.81	33.9	212	40	360

As mentioned above, polynitromethyl are considered to be more favorable groups to give remarkable improvements in densities and detonation properties of energetic materials. Especially the N-trinitroethylamination of nitropyrazole is more available since it is stable to be handled safely. The N-trinitroethylamination of dinitropyrazole was firstly proposed by Shreeve team [57]. They obtained several N-amino-dinitropyrazoles firstly, then these compounds underwent Mannich reactions with trinitroethanol to acquire the corresponding derivatives (46–50) (Figure 18, Scheme A). It was noteworthy that 1-amino-3,5-dinitropyrazole and 1-amino-3,4-dinitro-5-cyanopyrazole failed to get the corresponding compounds due to the electron-withdrawing effect of substituent groups bonded to dinitropyrazole ring. In addition, they employed an alternative synthetic method to obtain 1,5-diamino-3,4-dinitropyrazole (51) (Figure 18, Scheme B) because attempted amination of this compound using TsONH2 acid or NH2OSO3H failed. From Table 9, although the azido-functionalized dinitropyrazole (47) decomposed at 121 °C, compound 46 and 51 had high decomposition temperatures, and 47 and 50–52 owned higher density than RDX. These indicated the introduction of an -NH2 could enhance density. In addition, N-trinitroethylamination of dinitropyrazole (48–50 and 52) shown high HOF and good detonation properties. N-trinitromethyl moiety was introduced by Dalinger’s team [58], they synthesized 3,4-dinitro--1-(trinitromethyl)-pyrazoles (53) and 3,5-dinitro-1-(trinitromethyl)-pyrazoles (54) with excellent physical and computational properties as shown in Figure 19. They were a little less insensitive than the RDX and PETN, similar to N-trinitroethylamination dinitropyrazoles shown in Table 9. Fluorine and fluorinated functional groups are importantly promising substituents in the field of energetic materials [97]. C(NO2)2F and C(NO2)2NF2 moieties bring high energy, maintaining high density and good thermal property were incorporated into dinitropyrazole by fluorinated compound 55 (Figure 19, Scheme C). The two compounds had high density (≥1.92 g·cm−3), good oxygen balance (+2.55% for 57 and 0% for 56), and high detonation pressure and velocity [98].

Figure 18

N-Trinitroethylamination of dinitropyrazole.

Table 9

Physical and computational properties of several polynitropyrazoles. The data of compounds 46–52 are from reference [57], the data of compounds 53–54 are from reference [58].

Entry	ρ/g·cm−3	D/km·s−1	P/GPa	Tm/°C	Td/°C	HOF/kJ·mol−1	IS/J	FS/N
46	1.71	7.46	20.1	58	241	200.3	>40	360
47	1.82	9.05	35.8	120	121	548.2	1.5	5
48	1.78	8.67	33.1	87	110	142.3	6	80
49	1.82	9.00	35.6	-	117	491.7	2.5	20
50	1.81	8.75	34.3	-	116	124.1	12	120
51	1.82	8.69	32.8	133	238.2	173.0	>40	360
52	1.83	8.80	35.0	-	134.4	112.0	8	80
53	1.91	8.67	35.5	80	157	244.0	8	130
54	1.94	8.73	36.6	81	159	206.0	9	145

Figure 19

Synthesis of compounds 53–57.

Dinitropyrazoles bearing other heterocycles are also interesting and notable. To obtain the melt-castable explosives with good compatibility, improved oxygen balance and moderate detonation properties, compound 58 incorporating both N-trinitromethyl and C-methyl substituents in addition to nitro groups was synthesized by Sheremetev’s group [99] (Figure 20). This low melting temperature compound has been proved to own higher detonation pressure and velocity values than those of others melt-castable energetic heterocycles bearing methyl group, which provided feasible route to castable energetic materials. In addition, introduction of polynitrogen heterocycle and formation of energetic salts are main methods to improve the thermal stability of explosives [100]. In 2016, a heat-resistant energetic material, compound 59 bearing triazole ring, was synthesized using 5-amino-3-nitro-1H-1,2,4-triazole (ANTA) and 3,4,5-trinitrated-1H-pyrazole (TNP), and several salts based on it were developed by Zhou et al. [101] (Figure 21, Scheme A). As shown in Table 10, compound 59 had high decomposition temperature (270 °C) and high positive HOF (833 kJ·mol−1). All the salts showed good thermal stability, excellent insensitivity, and good detonation properties. In particular, the guanidinium salt 59d exhibited the best thermal stability superior than that of most explosives. Considering thermal stability and energetic properties, compounds 59 and 59d could be used as heat-resistant explosives and it was possible that these compounds can be applied as heat-resistant materials. Afterwards, their group reported a family of unsymmetrical N-bridged dinitropyrazoles synthesized by TNP and 5-amino-1H-tetrazole (ATZ) and its organic salts (Figure 21, Scheme B). Several compounds (60, 60b, and 60c) with high N contents exhibited superior detonation velocities but inferior detonation pressures compared to HMX and insensitivities to impact (IS > 40 J) and friction (FS > 360 N) comparable to those of TATB (Table 10), which could be promising insensitive HEDMs for practical application.

Figure 20

Synthesis of compound 58.

Figure 21

Synthesis of compounds 59–60i.

Table 10

Physical and computational properties of 59–60i. The data of compounds 59–59m are from reference [101], the data of compounds 60–60i and HMX are from reference [88].

Entry	ρ/g·cm−3	D/km·s−1	P/GPa	N/%	Td/°C	HOF/kJ·mol−1	IS/J	FS/N
59	1.84	9.17	37.8	44.2	270	833.4	9	240
59a	1.73	8.62	31.6	46.4	285	622.8	>40	>360
59b	1.76	8.83	34.4	44.0	215	709.9	33	252
59c	1.74	8.80	32.9	48.6	241	811.4	>40	>360
59d	1.78	8.66	31.1	48.8	340	624.1	>40	>360
59e	1.65	8.24	26.5	50.7	281	728.9	>40	>360
59f	1.70	8.54	28.9	52.4	262	831.7	27	240
59g	1.71	8.69	30.0	54.0	242	941.4	20	216
59h	1.72	8.36	28.8	51.0	279	828.3	>40	252
59i	1.74	8.56	29.5	52.6	292	944.8	>40	>360
59j	1.80	9.03	35.2	54.5	222	1211.7	12	252
59k	1.77	8.65	30.5	54.2	303	1166.1	20	>360
59l	1.75	-	-	41.0	261	-	7.5	252
59m	1.91	-	-	37.7	281	-	5	216
60	1.86	9.29	38.6	52.3	279	856.4	35	240
60a	1.79	8.95	33.3	54.3	299	672.6	>40	168
60b	1.84	9.23	37.4	51.1	296	719.7	>40	216
60c	1.84	9.36	37.0	56.4	290	819.8	>40	360
60d	1.67	8.26	25.9	56.0	256	648.8	>40	360
60e	1.72	8.76	28.6	61.2	216	808.7	>40	32
60f	1.79	9.07	32.5	59.4	285	844.9	>40	288
60g	1.81	9.29	34.2	60.9	287	954.9	>40	84
60h	1.84	8.95	32.2	57.6	286	840.2	>40	360
60i	1.82	9.00	32.3	59.1	261	960.0	>40	360
HMX	1.91	9.19	39.7	37.8	287	104.8	7.4	120

In summary, some dinitropyrazoles and derivatives exhibit low melting points and high decomposition temperatures as well as good detonation, which can make them competitive candidates for a castable explosive. To further improve the performance of dinitropyrazole-based energetic materials, a combination of several functional groups should be better, for example, the combination of nitramine and polynitrogen heterocyclic which can endow them with high thermal stability and good detonation performance.

2.3. Trinitropyrazole and Its Derivatives

TNP is the unique pyrazole compound by total carbon nitrification [102]. This compound owns good thermal stability (260–350 °C of Td) and chemical stability, and shows high detonation velocity (9.0 km·s−1) and detonation pressure (37.09 GPa). Wu et al. reviewed the synthesis of TNP in recent years in detail [102], including direct nitration methods, amino oxidation method, amino diazotization method, iodo nitrification method and microwave rearrangement method. The typical synthesis of TNP is the oxidation of LLM-116 rather than 5-amino-3,4-dinitropyrazole, and this is partly because the amino group in LLM-116 has higher electron cloud density and steric hindrance than amino group in 5-amino-3,4-dinitropyrazole, which can promote the intermolecular oxidation reaction and avoid the occurrence of intermolecular side reaction effectively, and partly because the “NO2-NH2-NO2” framework in LLM-116 makes it more stable and easier to synthesize. In addition, the nitrification of 3,5-DNP is another typical synthesis route of TNP. Traditional oxidation methods have the following defects: harsh reaction conditions, poor selectivity, by-products, high risk factor, expensive metal catalyst and toxic organic solvent. Although the synthesis of TNP with LLM-116 and 3,5-DNP as starting materials are mature, the synthesis of LLM-116 and 3,5-DNP are complicated. It is necessary to explore novel synthesis method. Zhao et al. [44] used LLM-116 as starting material, water as solvent, and KHSO5 as oxidant to synthesize TNP. Ravi et al. [103] put forward the nitration system of metal nitrate and studied the process of nitration to TNP. These two methods are promising to prepare TNP.

Moreover, 1-methyl-3,4,5-trinitropyrazole (MTNP), a derivative of TNP, is an insensitive energetic material with 91.5 °C of melting point, 248–280 °C of decomposition temperature, 8.65 km·s−1 of detonation velocity, and 33.7 GPa of detonation pressure [104]. Ravi et al. [103] added K-10 and TNP to bismuth impregnated in THF to obtain MTNP (Figure 22, Scheme A). There were also many routes to synthesize MTNP. Dalinger et al. [105,106] dissolved TNP in NaHCO3 aqueous solution with Me2SO4 as methylation reagent to acquire MTNP (Figure 22, Scheme B). Guo et al. [107] synthesized MTNP from 1-methyl-pyrazole by one-step method with nitric acid and fuming sulfuric acid (Figure 22, Scheme C). Among these methods, selection of highly efficient catalytic synthesis process and low toxicity methylation reagent are the trend in MTNP synthesis. In addition, 1-amino-3,4,5-trinitropyrazole (ATNP) is also a derivative of TNP with excellent detonation properties (D = 9.17 km·s−1 and P = 40.9 GPa) and thermal stability [108]. This was reported by Herve et al. [93], and the synthesis route is shown in Scheme D of Figure 22 (Pic-O-NH2 = 2,4,6-trinitrophenyl-O-hydroxylamine) with a yield of 26%.

Figure 22

Synthesis of MTNP and ATNP.

The N-H bond in TNP is easy to neutralize with alkali or react with metal salts forming energetic salts due to the stereoscopic structure and spatial effect of pryazole ring. These energetic salts further broaden the application of TNP. Zhang et al. [109] prepared a series of energetic salts of TNP based on nitrogen-rich cations (61a–m) (Figure 23, Scheme A), all the salts showed poorer densities and detonation properties than TNP (Table 11), but they owned good thermal stability and excellent insensitivity. Drukenmuller et al. [110] reported the synthesis of alkali and earth alkali trinitropyrazolate (62a–d) (Figure 23, Scheme B), compound 62d exhibited predominantly decomposition temperatures (Table 11). They also prepared pyrotechnic formulations using 62c and 62d, which showed good color properties and low sensitivity as well as high Td. In addition, Shreeve’s group [111] synthesized 3,4,5-trinitropyrazole-1-ol (63) and its nitrogen-rich salts (63a–g) (Figure 24) the corresponding properties are shown in Table 11. Compound 63 with its high oxygen content (51.13%) could be the green replacement of the currently used oxidizer (NH4ClO4), while the high IS (1 J) restricted its application. Compound 63a–g with acceptable impact sensitivities and detonation performance could be useful energetic materials.

Figure 23

Synthesis of different salts of TNP. (A), the polynitrogen salts; (B), the alkali and earth alkali salts.

Table 11

Property parameters of salts of TNP. The data of compounds 61a–61m are from reference [109], the data of compounds 62a–62d are from reference [110], the data of compounds 63–63g are from reference [111].

Entry	ρ/g·cm−3	D/km·s−1	P/GPa	Td/°C	HOF/kJ· mol−1	IS/J	FS/N
61a	1.73	8.46	29.9	224	60.5	40	-
61b	1.69	7.87	25.6	167	299.0	>40	-
61c	1.71	7.97	26.0	171	273.5	>40	-
61d	1.77	8.54	31.9	168	401.2	>40	-
61e	1.76	8.22	27.7	196	235.6	>40	-
61f	1.66	7.87	24.7	235	28.3	>40	-
61g	1.69	8.13	26.9	222	133.6	>40	-
61h	1.68	7.82	24.3	243	452.3	>40	-
61i	1.76	8.36	28.8	206	355.0	>40	-
61j	1.61	7.59	23.7	219	375.0	>40	-
61k	1.64	7.92	25.2	167	459.8	35	-
61l	1.62	7.98	25.3	197	246.5	>40	-
61m	1.65	8.24	27.2	184	352.7	>40	-
62a	-	-	-	274	-	40	96
62b	-	-	-	254	-	25	80
62c	-	-	-	193	-	40	80
62d	-	-	-	302	-	5	144
63	1.90	8.67	36.4	146	118.5	1	-
63a	1.82	8.68	35.1	176	35.1	6	-
63b	1.72	8.18	28.8	171	3.1	>40	-
63c	1.73	8.18	29.5	140	274.9	>40	-
63d	1.73	8.18	29.2	132	250.5	>40	-
63e	1.74	8.15	30.8	118	381.6	>40	-
63f	1.76	8.26	29.7	186	213.7	>40	-
63g	1.77	8.44	31.1	185	331.9	>40	-

Figure 24

Synthesis of compound 63 and its salts.

Polynitrogen heterocycle linking to TNP is a promising method to reach a balance between the energetic and physical properties of TNP, while there are a few references about it. Shreeve et al. [112] reported the synthesis of asymmetric N,N′-ethylene bridged 5-aminotetrazole and TNP moieties. They prepared 1-(2-(3,4,5-trinitro-1H-pyrazol-1-yl)ethyl)-1H-tetrazol-5-amine and 1-(3-(3,4,5-Trinitro-1H-pyrazol-1-yl)propyl)-1H-tetrazol-5-amine, and the two compounds were excellent insensitive and moderate powerful. In addition, they synthesized 5-((3,4,5-trinitro-1H-pyrazol-1-yl)methyl)-1H-tetrazole by N-methylene-C bridging TNP and tetrazole, which showed outstanding detonation properties and moderate insensitivity [113].

3. Nitrated-Bispyrazoles Based Compounds

Nitropyrazoles can be connected with nitrogen-rich heterocycles to obtain amazing energetic materials. In the previous section, nitropyrazoles bearing some polynitrogen heterocycles have been shown. Generally, these compounds exhibit some special properties, such as high detonation properties, good thermal stability, excellent safety, high density, and heat of formation, etc. Nitrated bispyrazoles also have attracted more and more attention, we will review the nitrated bispyrazole-based energetic materials in this section.

3.1. Directly Bridged Bis(Nitropyrazole)s

In 2014, Li et al. [27] synthesized several polynitro-substituted 1,4′-bridged-bispyrazoles energetic salts (64–67) as shown in Figure 25. They found that these compounds showed remarkable and unprecedented comprehensive properties (Table 12), and most of them with low toxicity were not hygroscopic. These compounds exhibited excellent impact sensitivities close to TATB, and the melting points and thermal decomposition temperatures were high, which could be applied as heat-resistant explosive. Compound 64 showed high Td approximating that of hexanitrostilbene (HNS, 316 °C). The energetic properties of compounds 64, 65, 65a, 66, and 67 were comparable with or superior to RDX, especially compound 66. In 2017, Tang et al. [114] prepared 4,4′,5,5′-tetranitro-2H,2′H-3,3′-bipyrazole (69) and its di-N-amino product (70), and the detailed route is described in Figure 26. Compound 70 showed good thermal stability and insensitivities as well as high detonation properties (Table 12). In addition, they synthesized 4,4′-dinitro-5,5′-diamino-2H,2′H-(3,3′-bipyrazole) (consisting of two 3-amino-4-nitropyrazole rings), this compound also show outstanding balance between thermal stability and safety (Table 12) [115]. Afterwards his team reported a variety of energetic materials based on compound 69 shown in Figure 27. Compounds 71, 73b, and 73h had high densities and good detonation velocities (Table 12), which were superior to RDX suggesting their use in secondary explosives. The dipotassium salt 73b had a high density of 2.029 g·cm−3 and excellent thermal stability of 323 °C, and could be applied as primary explosives [116]. However, the poor impact sensitivity might restrict their further application. In 2019, Domasevitch and co-authors [117] found an efficient approach towards facile accumulation of nitro functionalities at the pyrazole platform. Compounds 74, 75, and 76 were synthesized according to Figure 28. From Table 12, the three compounds owned high decomposition temperatures above 290 °C, especially for 75 and 76. The introduction of three and four -NO2 into the 4,4-bipyrazole scaffold could produce insensitive and thermally stable energetic materials with ideal densities and good detonation properties.

Figure 25

Synthesis of compounds 64–67.

Table 12

Physicochemical and energetic properties of compounds 64–76. The data of compounds 64–67 are from reference [27], the data of compounds 70 are from reference [114], the data of compounds 71–73i are from reference [116], the data of compounds 74–76 are from reference [117].

Entry	ρ/g·cm−3	D/km·s−1	P/GPa	Tm/°C	Td/°C	HOF/kJ· mol−1	IS/J	FS/N
64	1.96	8.72	36.0	269	308	185.4	>40	-
65	1.89	8.60	35.0	dec	242	388.1	>40	-
65a	1.88	8.62	34.6	dec	262	274.7	>40	-
65b	1.73	8.04	27.3	dec	228	246.5	>40	-
65c	1.67	8.09	27.1	249	272	506.4	>40	-
65d	1.71	8.20	27.9	210	272	448.8	>40	-
65e	1.72	8.34	29.0	212	266	558.0	>40	-
65f	1.75	8.33	31.1	dec	259	331.2	>40	-
65g	1.82	8.45	31.0	247	297	557.0	>40	-
65h	1.72	8.23	28.9	166	261	700.4	>40	-
65i	1.80	8.54	32.8	dec	260	428.1	>40	-
66	1.82	8.81	37.0	158	297	824.2	28	-
67	1.87	8.65	35.1	260	284	477.9	>40	-
70	1.76	8.50	31.0	-	252	475.7	30	360
71	1.88	8.99	36.0	-	150	347.4	5	240
72	1.92	8.04	28.9	150	228	-50.7	6	120
73a	2.03	7.77	27.3	-	323	-125.2	4	40
73b	1.85	8.85	35.8	-	137	220.6	8	240
73c	1.77	8.67	31.5	94	155	220.9	10	240
73d	1.76	8.34	29.4	-	193	116.2	10	240
73e	1.69	8.14	25.2	-	196	353.3	15	360
73f	1.75	8.31	27.3	185	186	791.9	16	360
73g	1.76	8.22	26.5	-	206	565.4	12	360
73h	1.81	8.95	34.2	187	193	1359.4	10	360
73i	1.80	8.54	28.9	-	250	1269.7	18	360
74	1.79	7.53	22.1	377	382	203.5	30	>360
75	1.81	8.36	28.6	306	314	224.9	20	>360
76	1.86	8.52	31.1	292	298	227.8	4.5	192

Figure 26

Synthesis of compounds 68–70.

Figure 27

Synthesis of compounds 71–73i.

Figure 28

Synthesis of compounds 74–76.

3.2. Alkyl-Bridged Bis(Nitropyrazoles)

Alkyl is also a good linkage to construct nitrogen-rich moieties, and many N,N′-alkyl-bridged energetic materials have been developed [112,118,119,120,121]. Yin et al. [122] developed a novel class of N,N′-ethylene-bridged bis(nitropyrazoles) with the synthetic route shown in Figure 29. Compounds 77–85 displayed various properties (Table 13) owing to the diversified functionalizations. Diaminobis(pyrazoles) showed good thermal stability, highly insensitivity, and favorable energetic performance; for example, the thermal decomposition temperature (311 °C) and detonation properties (27.9 GPa and 8.19 km·s−1) of 77 were higher than those of TNT, and were comparable to those of TATB. By contrast, N,N′-ethylene bridged dinitraminobis(pyrazoles) and diazidobis(pyrazoles) owned better detonation performances, while having higher impact and friction sensitivity. Compound 80 was the most promising energetic material with high density, favorable thermal stability, and good detonation properties, which were comparable to RDX. In addition, the relatively low impact and friction sensitivities of 80 showed good integrated properties, highlighting its potential application as a replacement of RDX. In 2016, Fischer et al. [123] synthesized three different bisnitropyrazole-based energetic materials by N,N′-methylene bridge (86–88), the detailed synthetic route is displayed in Scheme A of Figure 30. These energetic compounds could be used for different applications according to their properties (Table 13), compound 86 was a secondary explosive with a high Td (310 °C), enhanced detonation parameters by contrast with HNS, and high sensitivity to external stimuli. Compound 87 exhibited excellent detonation velocity (approximately to CL-20). The higher performance and better thermal stability of 88 was relative to DDNP making it a potential candidate as a green primary explosive. In addition, the synthetic routes are economical. Afterwards, their group used a similar route to prepare bis(3,4-dinitro-1H-pyrazol-1-yl)methane (89) and bis(3,5-dinitro-1H-pyrazol-1-yl)methane (90) with high decomposition temperature and low sensitivities having capability as future energetic materials (Table 13) [94]. Gozin et al. [124] explored the possible influence factor of the thermostable property of explosives, and under the guidelines they proposed, they synthesized the compounds 91 and 92 with excellent thermal stability and moderate sensitivities shown in Figure 31 and Table 13.

Figure 29

Synthesis of bis(nitropyrazoles) linked by N,N′-ethylene-bridge 77–85.

Table 13

Physicochemical and energetic properties of 74–87. The data of compounds 77–85 are from reference [122], the data of compounds 86–88, CL-20 and DDNP are from reference [123], the data of compounds 89–90 are from reference [94], the data of compounds 91–92 are from reference [124].

Entry	ρ/g·cm−3	D/km·s−1	P/GPa	OB/%	Td/°C	HOF/kJ·mol−1	IS/J	FS/N
77	1.77	8.19	27.9	−17.2	311	218.9	>40	>360
78	1.84	8.75	34.3	3.5	80	380.6	7	80
79	1.72	7.80	24.2	−19.0	247	441.9	20	80
80	1.84	8.76	34.1	7.4	250	306.9	25	160
81	1.78	8.80	33.4	−7.5	112	1233.9	4	60
82	1.88	7.88	27.0	−7.8	319	230.0	>40	>360
83	1.76	8.56	31.0	−7.5	135	1013.9	3	60
84	1.75	8.13	27.3	−17.2	256	237.9	>40	>360
85	1.83	8.71	33.7	3.5	81	368.1	6	60
86	1.80	8.33	29.6	−40.2	310	205	11	>360
87	1.93	9.30	39.1	−11.5	205	379	4	144
88	1.73	8.02	26.0	−44.7	226	497	1.5	40
89	1.76	8.14	28.0	−39.0	319	302	25	360
90	1.72	7.97	26.3	−39.0	330	266	35	360
91	1.81	8.23	28.6	−39.0	262	224.2	14	352
92	1.81	8.36	29.7	−51.4	351	184.3	10	352
CL-20	2.04	9.67	44.9	−11.0	195	365	3	96
DDNP	1.72	76.5	23.8	−60.9	157	139	1	5

Figure 30

Synthesis of bis(nitropyrazoles) linked by N,N′-methylene-bridge 86–90.

Figure 31

Synthesis of compounds 91 and 92.

3.3. Ring-Bridged Bis(Nitropyrazoles)

Ring-bridge is an important connector linking bis(nitropyrazoles) to obtain high performance energetic materials. Pagoria et al. [125] reported the trimerization of LLM-116. 4-Diazo-3,5-bis(4-amino-3,5-dinitropyrazol-1-yl) pyrazole (93) containing a stable diazo group was synthesized, and the detailed route is shown in Figure 32. Compound 93 was more thermally stable (278 °C of Td) than LLM-116, attributing to the considerable hydrogen bonding between -NH2 and -NO2, and the short contact between the =N2 and -NO2 through the intermolecular interactions. Moreover, it was insensitive to impact, friction, and spark. Yan et al. [126] designed mono and bi(1,2,4-oxadiazole) rings to bridge polynitropyrazoles (Figure 33). Among compounds 94–99, 98, and 99 owned the highest detonation velocity of 8.90 and 8.87 km·s−1, detonation pressure of 35.1 and 34.5 GPa, respectively. 94 and 95 processed good stability (272–274 °C) and good insensitivity (IS > 30 J and FS > 360 N) as well as high detonation properties (8.69–8.74 km·s−1 of D and 33.4–34.0 GPa of P). 96 and 97 had the high thermal stability over 310 °C and good sensitivity (IS > 40 J, FS > 360 N). Comparing with the conventional heat resistant explosive HNS, 96 and 97 owned better detonation properties (7.99–8.03 km·s−1 of D, 25.2–26.4 GPa of P). Also, their team used the similar routes to synthesize the bis(nitropyrazoles) with 1,3,4-oxadiazole (100–105) [127]. The properties of these compounds are showed in Table 14. Moreover, Li et al. [124] synthesized the compound 106 with the procedure shown in Figure 34. This compound exhibited an excellent decomposition temperature (341 °C), high calculated detonation velocity of 8.52 km·s−1, and detonation pressure of 30.6 GPa. It also showed impressive insensitivities (IS = 22 J, FS = 352, and ESD = 1.05 J). These showed building ring bridged bis(nitropyrazoles) can be an effective approach to enhance the properties of energetic materials.

Figure 32

Synthesis of compound 93.

Figure 33

Synthesis of compounds 94–99, and chemical structures of compounds 100–105.

Table 14

Physical and energetic properties of energetic compounds 100–105. The data of compounds 100–105 are from reference [127].

Entry	ρ/g·cm−3	D/km·s−1	P/GPa	Td/°C	HOF/kJ· mol−1	IS/J	FS/N
100	1.80	8.10	27.1	338	521.6	>40	>360
101	1.81	8.05	26.5	368	639.8	>40	>360
102	1.83	8.86	34.2	159	762.1	8	150
103	1.84	8.77	33.3	186	882.4	13	220
104	1.87	8.71	32.8	265	602.7	30	360
105	1.84	8.54	31.7	254	519.4	35	>360

Figure 34

Synthesis of compound 106.

In addition, there are some other fused ring-bridged bis(nitropyrazoles). In 2017, Yin and co-authors [128] synthesized compound 109 and its derivatives according to the procedure shown in Figure 35, and their physicochemical and energetic properties are shown in Table 15. Among these compounds, 107a had a high density and decomposition temperature as well as the good safety parameters. The introduction of nitramino group gave 110 and 111 highest detonation velocities and pressures, while they also exhibited sensitive properties to mechanical stimuli. Considering the whole aspect, 108a was featured with promising integrated energetic performance exceeding those of the benchmark explosive RDX. Shreeve’s group prepared (112) obtained from compound 69 by N-azo coupling reactions shown in Scheme A of Figure 36 [114]. Compound 112 had a high density of 1.955 g·cm−3 and a good thermal stability (233 °C). Its detonation properties (9.63 km·s−1 and 44.0 GPa) were comparable to CL-20, much better than those of RDX and HMX. In addition, the IS of 10 J and FS of 240 N showed it was more stable than CL-20. These indicated compound 112 was a superior energetic explosive. In 2018, her team developed an efficient synthetic method of ring closure of polynitropyrazoles with N,N′-ethylene/propylene bridges (Figure 36, Scheme B). Compounds 113 and 114 showed excellent thermal stability (261 °C for 113, 280 °C for 114), good detonation properties and moderate insensitivities, making them potential candidates as HEDMs. This ring closure strategy could provide new ideas of designing thermally stable explosives.

Figure 35

Synthesis of compounds 107a–111.

Table 15

Physicochemical and energetic properties of compounds 107a–111. The data of compounds 107a–111 are from reference [128].

Entry	ρ/g·cm−3	D/km·s−1	P/GPa	Td/°C	HOF/kJ· g−1	IS/J	FS/N
107a	1.90	8.79	34.3	261	1.10	15	240
107b	1.82	8.52	31.7	220	0.97	40	360
108a	1.86	8.89	35.9	221	1.05	35	360
108b	1.83	8.69	33.2	207	1.33	25	360
109	1.79	8.36	29.6	242	0.96	15	160
110	1.94	9.23	38.8	117	1.30	3	20
111	1.87	9.03	37.1	138	1.32	10	80

Figure 36

Synthesis of compounds 112–114.

3.4. DCNP-Bridged Bis(Nitropyrazoles)

It is known that 1,3-Dichloro-2-nitro-2-azapropane (DCNP) is an useful precursor connecting nitropyrazoles via nucleophile substitution [129]. In 2013, Zhang et al. [130] reported a family of functionalized dipyrazolyl N-nitromethanamines (compounds 115–122 in Figure 37) using DCNP as the bridge. These compounds exhibited densities between 1.69–1.90 g·cm−3 and thermal stabilities range from 166–354 °C. From Table 16, it was easy to see the introduction of the azidodinitropyrazolate group led to the most competitive detonation properties (35.1 GPa and 8.72 km·s−1 for 121, 35.2 GPa and 8.72 km·s−1 for 122). However, they showed high sensitivity (IS = 2 J). Compound 119 exhibited good physical and detonation properties, such as high thermal stability, density, HOF, detonation pressure and velocity, and great impact stability, which could be used a promising HEDM. Klapötke et al. [131] also reported these compounds. They applied a different synthesis method of DNCP by the nitration of hexamethylenetetramine, and the NaBr/acetone system was used to substitution reaction.

Figure 37

Synthesis of nitrated bispyrazoles 115-122 from 1,3-dichloro-2-nitro-2-azapropane.

Table 16

Properties of nitrated bispyrazoles from 1,3-dichloro-2-nitro-2-azapropane. The data of compounds 115–122 are from reference [130].

Entry	ρ/g·cm−3	D/km·s−1	P/GPa	Td/°C	HOF/kJ· mol−1	IS/J	OB/%
115	1.69	7.87	25.1	262	377.2	>40	−30.8
116	1.78	8.26	30.9	250	388.0	10	−4.0
117	1.78	8.27	31.0	261	398.0	>40	−4.0
118	1.90	8.06	30.6	252	371.8	11	0
119	1.86	8.64	34.7	232	486.4	>40	−7.4
120	1.89	8.04	30.4	354	381.3	>40	0
121	1.83	8.72	35.1	166	1108.2	2	0
122	1.83	8.72	35.2	169	1118.7	2	0

In general, the physical and energetic properties of bridged bis(nitropyrazole)s can be adjusted by the bridged groups. The design of novel bridged group would be a key factor to synthesize new HEDMs, and forming polycyclic derivatives even cage compounds could be more attractive. In addition, the salts of bridged bis(nitropyrazole)s should be explored in-depth.

4. Nitrated Pyrazolo[4,3-c]Pyrazoles and Their Derivatives

Application of molecular design and explosive performance prediction has explored many novel energetic materials based on pyrazolopyrazole ring system [2,132,133]. Heterocycles like pyrazolo-pyrazole always own high density and oxygen balance, good thermal stability, and enhanced energetic performance of an energetic material.

3,6-Dinitropyrazolo[4,3-c]pyrazole (DNPP) is a new type of energetic material with attractive properties (1.865 g·cm−1 of ρ, 42.42% of nitrogen content, 273 kJ·mol−1, 330.8 °C of Td and 68 cm of D50). This compound synthesized from 3,5-dimethylpyrazole was firstly reported by Dalinger and co-workers [134]. Pagoria et al. [135] improved the synthetic route to DNPP as shown in Scheme A of Figure 38. In this procedure, 4-diazo-3,5-dimethylpyrazole salt is an important intermediate. Li et al. [136] improved the process of 4-diazo-3,5-dimethylpyrazole salt using freezing crystallization instead of extraction which avoided large use of organic solvents and improved its yield. This procedure has several advantages, such as ease of synthesis scale-up and better product yield. In addition, Luo et al. [137] proposed that DNPP could be obtained by dehydration condensation, primary nitration, reduction, diazotization, cyclization, secondary nitration, oxidation, and decarboxylation nitration with acetylacetone and hydrazine hydrate as raw materials (Figure 38, Scheme B).

Figure 38

Synthesis of DNPP.

Due to the active N-H bond in molecule of DNPP, it is easy to obtain its energetic salts. In 2014, Zhang et al. [138] reported a series of nitrogen-rich energetic salts based on the anion of DNPP (123a–m) shown in Figure 39. Salts 123a–e could be obtained by reacting DNPP with ammonia, hydrazine, hydroxylamine, 3,5-diamino-1,2,4-triazole, and 3,4,5-triamino-1,2,4-triazole. Salts 123f–j could be synthesized by reacting Na2DNPP with guanidine nitrate, aminoguanidine, diaminoguanidine, triaminoguanidinium, and 2-iminium-5-nitriminooctahydroimidazo [4,5-d]imidazole hydrochlorides. Salts 123k–m were acquired by the reaction of DNPP with NaOH, KOH and AgNO3 respectively. Table 17 displays the properties of these energetic salts. It was notable that the ammonium salt (123a), hydroxylammonium salt (123b) and guanidinium salt (123f) exhibited outstanding decomposition temperatures of >300 °C. Furthermore, the sodium salt (123k) and potassium (123l) salt of DNPP were thermally stable up to 395 °C and 365 °C, respectively. In addition, most of the salts showed high calculated detonation properties, especially 123b owned the highest detonation velocity and pressure. Considering the balance of safety and energetic properties as well as physical properties, 123b could be a competitive candidate in insensitive HEDMs. Luo and co-authors synthesized the basic lead salt of DNPP (Pb-DNPP) and the 3,6-dihydrazine-1,2,4,5-tetrazine salt of DNPP (DHT-DNPP), and studied their thermal decomposition behaviors. Like 123k–m, the introduction of heavy cations made the salts higher densities and Td. Combining other organic amines salts of DNPP [139], these salts showed good thermal stabilities.

Figure 39

Synthesis of salts of DNPP.

Table 17

Properties of energetic compounds 123a–m. The data of compounds 123a–123m are from reference [138].

Entry	ρ/g·cm−3	D/km·s−1	P/GPa	Td/°C	HOF/kJ· mol−1	IS/J	FS/N	OB/%
123a	1.69	8.21	25.4	328	158.5	>40	360	−27
123b	1.82	9.01	35.4	327	274.2	29	360	−12
123c	1.72	8.86	30.3	247	501.0	16	160	−30
123d	1.71	8.04	24.5	287	481.9	>40	360	−30
123e	1.67	8.23	24.6	289	963.8	>40	360	−41
123f	1.68	7.95	22.5	324	173.3	>40	360	−40
123g	1.69	8.40	25.6	222	477.0	>40	360	−41
123h	1.71	8.73	28.0	209	679.6	>40	360	−42
123i	1.76	8.81	29.9	215	605.5	12	80	−31
123j	1.79	8.36	27.9	238	505.6	23	160	−27
123k	2.14	-	-	395	-			0
123l	2.20	-	-	365	-			0
123m	3.27	-	-	327	-			0

In addition, 1,4-Diamino-3,6-dinitropyrazolo[4,3-c]pyrazole (LLM-119) is a derivative of DNPP with a predicted energy of 104% HMX and good insensitivity to friction and electric spark stimulation [2]. It is also a very important intermediate of synthesizing novel high-performance energetic materials. Li et al. [140] used NaOH and H2NOSO3H to realize the N-amination of DNPP, while the yield was low (10.4%). Yin reported a modified procedure using 1,8-diazabicycloundec-7-ene (DBU) and O-tosylhydroxylamine (TsONH2) as organic solvents with a good yield [141]. He also developed a series of DNPP derivatives based on N-functionalization strategy including several ionic salts of DNPP, the synthesis route is displayed in Figure 40 (Scheme A). As shown in Table 18, compounds 125, 126 and 126c exhibited high densities and excellent detonation velocities and pressures, which were superior to the current secondary explosive benchmark HMX. These compounds except 126d and 126e were sensitive to stimulation, especially for 126i also showed excellent density and good thermal stability. These could make compound the potassium salt as a green primary explosive. Compounds 126a, 126b, 126c and 126g showed good possibilities for application in bipropellants owing to the high values of (N + O) content and specific impulse. Li and co-author [142] synthesized another four kinds of neutral explosives based on N-functionalization of DNPP shown in Scheme B of Figure 40. Comparing with LLM-119, compound 127 showed slightly lower energetic and physical properties due to the only one -NH2. Compounds 130 owned the relatively high density, good thermal stability, outstanding detonation properties, and reasonable sensitivities, which could be a useful energetic material. Li et al. [143,144] also synthesized several salts of N-nitramino DNPP, which exhibited good energetic properties.

Figure 40

Synthesis of N-functional derivatives of DNPP.

Table 18

Physical and detonation properties of energetic compounds LLM-119 and 124–130. The data of compounds LLM-119 and 124–126i are from reference [141], the data of compounds 127–130 are from reference [142].

Entry	ρ/g·cm−3	D/km·s−1	P/GPa	Td/°C	HOF/kJ·mol−1	IS/J	FS/N	OB/%	N + O/%	Isp/s
LLM-119	1.84	8.86	33.9	230	467.0	15	160	−14.0	77.2	246
124	1.82	8.67	33.1	206	133.7	10	120	9.2	78.2	245
125	1.96	9.46	40.9	145	550.9	3	20	22.2	83.3	269
126	1.93	9.51	41.8	128	595.2	2	20	15.1	84.3	274
126a	1.81	8.98	35.9	181	423.1	10	120	0	84.1	270
126b	1.85	9.40	39.5	174	738.9	5	60	−4.2	84.8	280
126c	1.88	9.50	41.3	170	531.2	7	120	8.3	85.4	282
126d	1.68	8.30	26.9	190	454.7	35	360	−14.7	80.7	239
126e	1.71	8.61	29.3	153	692.9	30	360	−17.2	81.5	247
126f	1.70	8.88	30.8	141	1144.8	10	80	−21.3	82.8	258
126g	1.78	9.17	36.0	163	1683.3	5	60	−9.3	84.2	280
126h	1.83	9.00	33.1	203	1599.5	10	120	−23.0	78.6	244
126i	2.11	8.31	31.2	208	152.9	2	20	16.2	68.0	226
127	1.74	7.93	27.9	178	356.0	14	280	−41.3	76.0	-
128	1.83	8.48	32.8	208	18.8	12	160	−18.4	78.2	-
129	1.74	7.82	27.1	198	863.0	10	240	−51.9	75.3	-
130	1.90	8.84	36.5	296	269.0	16	300	−20.9	78.2	-

In addition, Zhang et al. [145] introduced the dinitromethyl group and fluorodinitromethyl group into DNPP molecule and synthesized five fused-ring energetic derivatives (131–132) shown in Figure 41. Among these compounds, the dipotassium salt (131a) was formed as an interesting three-dimensional metal-organic framework (MOF) and exhibited outstanding detonation performances (9.02 km·s−1 of D and 33.6 GPa of P), which were comparable to that of Pd(N3)2. The compound 132 had a high density of 1.939 g·cm−3, high decomposition temperature of 213 °C and desired mechanical sensitivities (IS: 12 J; FS: 240 N), which could be a competitive candidate of RDX. These energetic compounds containing dinitromethyl or fluorodinitromethyl group enrich the energetic compound library of pyrazolo[4,3-c]pyrazoles. Furthermore, their group incorporated two tetrazole groups into DNPP molecule, and synthesized 3,6-dinitro-1,4-di(1H-tetrazol-5-yl)-pyrazolo[4,3-c]pyrazole (133) and its ionic derivatives (133a–f) shown in Figure 42 [146]. The physicochemical and energetic properties of these compounds are shown in Table 19. These compounds were thermally stable and insensitive to mechanical stimulation. The potassium salt (133a) possessed a high thermal decomposition temperature (329 °C of Td) and low sensitivities (IS: 25 J; FS: 252 N). In contrast with other derivatives from DNPP, compound 133f owned the best mechanical sensitivities (IS: >60 J; FS: >360 N). Compounds 133, 133a, and 133d possessed good comprehensive properties, including remarkable thermal decomposition temperatures, excellent insensitivity, and favorable detonation performance.

Figure 41

Synthesis of derivatives of DNPP containing dinitromethyl and fluorodinitromethyl group.

Figure 42

Synthesis of derivatives of DNPPP containing tetrazole groups.

Table 19

Physicochemical and energetic properties of 133 and its ionic salts. The data of compounds 133–133f are from reference [146].

Entry	ρ/g·cm−3	D/km·s−1	P/GPa	Td/°C	HOF/kJ·mol−1	IS/J	FS/N
133	1.79	8.72	30.9	281	1111.5	15	192
133a	2.00	8.81	28.5	329	638.9	25	252
133b	1.69	8.40	26.2	280	916.8	19	>360
133c	1.61	8.24	26.0	178	1062.2	27.5	324
133d	1.75	9.08	31.3	221	1223.0	12	144
133e	1.62	8.02	22.4	299	926.9	>60	>360
133f	1.64	8.40	24.9	255	1143.3	35	>360

Nitrated pyrazolo[4,3-c]pyrazoles own acceptable performances both the energetic and physical properties, further functionalization of these compounds could be interesting. However, the synthesis of DNPP are still multistep reactions with unsatisfactory yield. The more efficient and facile synthesis technology should be investigated.

5. Conclusions

In recent years, a lot of scholars over the world have paid much attention to the development of nitrogen-rich heterocyclic energetic materials, due to their high positive heat of formation, low sensitivity, tailored thermal stability, and attractive detonation performance. According to the reference [37], a new energetic compound should be environmentally friendly, easy and economical to synthesize, thermal stable (Td > 200 °C), insensitive to mechanical stimulation (IS > 7 J; FS > 120 N), good detonation properties (D > 8.5 km·s−1), and not insoluble in water. For the nitropyrazoles-based energetic materials, most of them can meet these requirements. Some nitropyrazole-based compounds show good performance as castable explosives, such as compounds 1, 2, 3, 5, 3,4-DNP, 46, 48, 53, 54, and MTNP, which are competitive candidates of TNT. Some exhibited excellent thermal stability such as compounds 17, 28, 37, 64, 75, 86, 90, 92, 101, 120, DNPP, etc. Further, many showed a balance between good safety and high detonation performance. The introduction of high-nitrogen groups (including fused-ring, polynitramino group, polynitromethyl group, etc) to nitropyrazoles can be useful approach for the further development of new-generation HEDMs. In addition, the concept of forming ionic salts, bridged structures and pyrazolo-pyrazoles provides novel insights to synthesize high performance energetic materials. It is better to synthesize new energetic compounds under the direction of theoretical calculation, so it is important to understand the relationship between structures and properties for the design and synthesis of new nitropyrazoles-based energetic materials.

Furthermore, there are some areas requiring improvement for the further synthesis of novel nitropyrazoles-based EMs. First, traditional nitration is generally used in the synthesis of nitropyrazoles-based EMs, which does not meet the requirements of modern green chemistry. It is vital to find out the suitable green nitrating agents and catalysts in the future synthesis process. Second, many syntheses of nitropyrazoles-based EMs entail several steps, leading to a low yield and high cost. Therefore, it is necessary to search for an efficient route when preparing new HEDMs.