Literature DB >> 32749092

DNA Methylation in T-Cell Development and Differentiation.

Luis O Correa1, Martha S Jordan2, Shannon A Carty3.   

Abstract

T lymphocytes undergo carefully orchestrated programming during development in the thymus and subsequently during differentiation in the periphery. This intricate specification allows for cell-type and context-specific transcriptional programs that regulate immune responses to infection and malignancy. Epigenetic changes, including histone modifications and covalent modification of DNA itself through DNA methylation, are now recognized to play a critical role in these cell-fate decisions. DNA methylation is mediated primarily by the actions of the DNA methyltransferase (DNMT) and ten-eleven-translocation (TET) families of epigenetic enzymes. In this review, we discuss the role of DNA methylation and its enzymatic regulators in directing the development and differentiation of CD4+ and CD8+ T-cells.

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Year:  2020        PMID： 32749092      PMCID： PMC8048391          DOI： 10.1615/CritRevImmunol.2020033728

Source DB:  PubMed          Journal:  Crit Rev Immunol        ISSN： 1040-8401            Impact factor:   1.735


  140 in total

1.  The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds.

Authors:  Chen Qiu; Ken Sawada; Xing Zhang; Xiaodong Cheng
Journal:  Nat Struct Biol       Date:  2002-03

2.  Helper T cell differentiation is controlled by the cell cycle.

Authors:  J J Bird; D R Brown; A C Mullen; N H Moskowitz; M A Mahowald; J R Sider; T F Gajewski; C R Wang; S L Reiner
Journal:  Immunity       Date:  1998-08       Impact factor: 31.745

3.  Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation.

Authors:  S Agarwal; A Rao
Journal:  Immunity       Date:  1998-12       Impact factor: 31.745

4.  Whole-exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutations.

Authors:  Martin Neumann; Sandra Heesch; Cornelia Schlee; Stefan Schwartz; Nicola Gökbuget; Dieter Hoelzer; Nikola P Konstandin; Bianka Ksienzyk; Sebastian Vosberg; Alexander Graf; Stefan Krebs; Helmut Blum; Thorsten Raff; Monika Brüggemann; Wolf-Karsten Hofmann; Jochen Hecht; Stefan K Bohlander; Philipp A Greif; Claudia D Baldus
Journal:  Blood       Date:  2013-04-19       Impact factor: 22.113

5.  Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites.

Authors:  Atanu Maiti; Alexander C Drohat
Journal:  J Biol Chem       Date:  2011-08-23       Impact factor: 5.157

6.  RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis.

Authors:  Jose R Cortes; Alberto Ambesi-Impiombato; Lucile Couronné; S Aidan Quinn; Christine S Kim; Ana C da Silva Almeida; Zachary West; Laura Belver; Marta Sanchez Martin; Laurianne Scourzic; Govind Bhagat; Olivier A Bernard; Adolfo A Ferrando; Teresa Palomero
Journal:  Cancer Cell       Date:  2018-02-02       Impact factor: 31.743

7.  Identification of DNA methyltransferase 3a as a T cell receptor-induced regulator of Th1 and Th2 differentiation.

Authors:  Christopher J Gamper; Agoston T Agoston; William G Nelson; Jonathan D Powell
Journal:  J Immunol       Date:  2009-07-22       Impact factor: 5.422

8.  Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies.

Authors:  Omar Abdel-Wahab; Ann Mullally; Cyrus Hedvat; Guillermo Garcia-Manero; Jay Patel; Martha Wadleigh; Sebastien Malinge; JinJuan Yao; Outi Kilpivaara; Rukhmi Bhat; Kety Huberman; Sabrena Thomas; Igor Dolgalev; Adriana Heguy; Elisabeth Paietta; Michelle M Le Beau; Miloslav Beran; Martin S Tallman; Benjamin L Ebert; Hagop M Kantarjian; Richard M Stone; D Gary Gilliland; John D Crispino; Ross L Levine
Journal:  Blood       Date:  2009-05-06       Impact factor: 22.113

9.  Dnmt3a regulates T-cell development and suppresses T-ALL transformation.

Authors:  A C Kramer; A Kothari; W C Wilson; H Celik; J Nikitas; C Mallaney; E L Ostrander; E Eultgen; A Martens; M C Valentine; A L Young; T E Druley; M E Figueroa; B Zhang; G A Challen
Journal:  Leukemia       Date:  2017-03-21       Impact factor: 11.528

10.  Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus.

Authors:  Yongqiang Feng; Aaron Arvey; Takatoshi Chinen; Joris van der Veeken; Georg Gasteiger; Alexander Y Rudensky
Journal:  Cell       Date:  2014-08-14       Impact factor: 41.582
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  5 in total

Review 1.  Micro but mighty-Micronutrients in the epigenetic regulation of adaptive immune responses.

Authors:  Heng-Yi Chen; Michael Hsu; Chan-Wang Jerry Lio
Journal:  Immunol Rev       Date:  2021-11-24       Impact factor: 12.988

Review 2.  Abnormal Epigenetic Regulations in the Immunocytes of Sjögren's Syndrome Patients and Therapeutic Potentials.

Authors:  Peng Li; Mengwei Han; Xingyu Zhao; Guanqun Ren; Si Mei; Chao Zhong
Journal:  Cells       Date:  2022-05-27       Impact factor: 7.666

Review 3.  Epigenetic Alterations in Inborn Errors of Immunity.

Authors:  Roberta Romano; Francesca Cillo; Cristina Moracas; Laura Pignata; Chiara Nannola; Elisabetta Toriello; Antonio De Rosa; Emilia Cirillo; Emma Coppola; Giuliana Giardino; Nicola Brunetti-Pierri; Andrea Riccio; Claudio Pignata
Journal:  J Clin Med       Date:  2022-02-25       Impact factor: 4.241

Review 4.  Methionine cycle-dependent regulation of T cells in cancer immunity.

Authors:  Tian Zhao; Julian J Lum
Journal:  Front Oncol       Date:  2022-08-10       Impact factor: 5.738

Review 5.  DNA Methylation in Regulatory T Cell Differentiation and Function: Challenges and Opportunities.

Authors:  Lu Bai; Xiaolei Hao; Julia Keith; Yongqiang Feng
Journal:  Biomolecules       Date:  2022-09-12
  5 in total

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