Literature DB >> 3274897

Regulation of 70-kilodalton heat-shock-like messenger ribonucleic acid in vitro and in vivo by prolactin.

S M deToledo1, L J Murphy, T H Hatton, H G Friesen.   

Abstract

A cDNA clone, pNb29, was isolated from a library made from mRNA of Nb2 rat lymphoma cells stimulated by PRL. The nucleotide sequence of pNb29 was found to be identical to the 70-kilodalton heat-shock-like (hsp-70-like) mRNA. The levels of this mRNA increased 8 +/- 3-fold after PRL stimulation of arrested Nb2 cells, and is expressed in different amounts in the normal rat tissues analyzed. To determine whether hsp-70-like mRNA was PRL responsive in vivo, ovine PRL was administered to hypophysectomized rats. A 5 +/- 2-fold increase in hepatic hsp-70-like mRNA was observed 9 h after injection. Thus PRL appears to regulate a heat-shock-like mRNA both in vitro and in vivo. This novel finding extends the already wide range of biological effects ascribed to PRL.

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Year:  1987        PMID： 3274897     DOI： 10.1210/mend-1-6-430

Source DB:  PubMed          Journal:  Mol Endocrinol        ISSN： 0888-8809


  6 in total

1.  Aging differentially modulates the expression of collagen and collagenase in dermal fibroblasts.

Authors:  M R Khorramizadeh; E E Tredget; C Telasky; Q Shen; A Ghahary
Journal:  Mol Cell Biochem       Date:  1999-04       Impact factor: 3.396

2.  Differential expression of insulin-like growth factor-I and insulin-like growth factor binding protein-1 in the diabetic rat.

Authors:  J M Luo; L J Murphy
Journal:  Mol Cell Biochem       Date:  1991-04-24       Impact factor: 3.396

3.  Interferon-regulatory factor 1 is an immediate-early gene under transcriptional regulation by prolactin in Nb2 T cells.

Authors:  L Y Yu-Lee; J A Hrachovy; A M Stevens; L A Schwarz
Journal:  Mol Cell Biol       Date:  1990-06       Impact factor: 4.272

4.  Expression and regulation of insulin-like growth factor binding protein-1 in the rat uterus throughout estrous cycle.

Authors:  A Ghahary; J Luo; L J Murphy
Journal:  Mol Cell Biochem       Date:  1993-07-07       Impact factor: 3.396

5.  Interleukin 2 and a lactogen regulate proliferation and protein phosphorylation in Nb2 cells.

Authors:  E J Rayhel; T J Fields; J W Albright; T Diamantstein; J P Hughes
Journal:  Biochem J       Date:  1988-01-15       Impact factor: 3.857

6.  Analysis of prolactin-modulated gene expression profiles during the Nb2 cell cycle using differential screening techniques.

Authors:  C Bole-Feysot; E Perret; P Roustan; B Bouchard; P A Kelly
Journal:  Genome Biol       Date:  2000-10-16       Impact factor: 13.583
  6 in total

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