Literature DB >> 3274895

Rat corticotropin-releasing hormone gene: sequence and tissue-specific expression.

R C Thompson1, A F Seasholtz, E Herbert.   

Abstract

The rat corticotropin releasing hormone (CRH) gene has been isolated and characterized by DNA sequence analysis. The gene exhibits a structural organization similar to that of the human CRH gene. The nucleotide sequence encoding the entire rat CRH precursor is located on the second exon, while exon I encodes the 5'-untranslated region of the mRNA. Analysis of the nucleotide sequence homology between the human and rat CRH genes reveals several highly conserved regions including the CRH peptide-encoding sequence and the 5'-flanking sequence. RNA blot analysis demonstrates that CRH mRNA can be observed in numerous regions of the rat brain as well as the spinal cord, adrenal gland, pituitary, and testis.

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Year:  1987        PMID： 3274895     DOI： 10.1210/mend-1-5-363

Source DB:  PubMed          Journal:  Mol Endocrinol        ISSN： 0888-8809


  33 in total

1.  Expression of corticotropin-releasing factor in inflamed tissue is required for intrinsic peripheral opioid analgesia.

Authors:  M Schafer; S A Mousa; Q Zhang; L Carter; C Stein
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-11       Impact factor: 11.205

2.  In situ hybridization of corticotropin-releasing factor-encoding messenger RNA in the hypothalamus of the white sucker, Catostomus commersoni.

Authors:  Y Okawara; D Ko; S D Morley; D Richter; K P Lederis
Journal:  Cell Tissue Res       Date:  1992-03       Impact factor: 5.249

3.  Functional CRH variation increases stress-induced alcohol consumption in primates.

Authors:  Christina S Barr; Rachel L Dvoskin; Manisha Gupte; Wolfgang Sommer; Hui Sun; Melanie L Schwandt; Stephen G Lindell; John W Kasckow; Stephen J Suomi; David Goldman; J Dee Higley; Markus Heilig
Journal:  Proc Natl Acad Sci U S A       Date:  2009-08-17       Impact factor: 11.205

4.  The testicular effects of tumor necrosis factor.

Authors:  K Mealy; B Robinson; C F Millette; J Majzoub; D W Wilmore
Journal:  Ann Surg       Date:  1990-04       Impact factor: 12.969

5.  One evidence of cocaine- and amphetamine-regulated transcript (CART) has the bidirectional effects on appetite in Siberian sturgeon (Acipenser baerii).

Authors:  Xin Zhang; Yundi Gao; Ni Tang; Jinwen Qi; Yuanbing Wu; Jin Hao; Shuyao Wang; Defang Chen; Zhiqiong Li
Journal:  Fish Physiol Biochem       Date:  2017-11-16       Impact factor: 2.794

6.  Characterization and gestational regulation of corticotropin-releasing hormone messenger RNA in human placenta.

Authors:  D M Frim; R L Emanuel; B G Robinson; C M Smas; G K Adler; J A Majzoub
Journal:  J Clin Invest       Date:  1988-07       Impact factor: 14.808

7.  Expression of the mouse corticotropin-releasing hormone gene in vivo and targeted inactivation in embryonic stem cells.

Authors:  L J Muglia; N A Jenkins; D J Gilbert; N G Copeland; J A Majzoub
Journal:  J Clin Invest       Date:  1994-05       Impact factor: 14.808

8.  Stress-induced activation of neuronal activity and corticotropin-releasing factor gene expression in the paraventricular nucleus is modulated by glucocorticoids in rats.

Authors:  T Imaki; W Xiao-Quan; T Shibasaki; K Yamada; S Harada; N Chikada; M Naruse; H Demura
Journal:  J Clin Invest       Date:  1995-07       Impact factor: 14.808

9.  The effects of naloxone on the cardiovascular and respiratory effects of centrally administered corticotrophin releasing factor in conscious rabbits.

Authors:  C N May; C J Whitehead; C J Mathias
Journal:  Br J Pharmacol       Date:  1991-07       Impact factor: 8.739

Review 10.  Neuropeptides of the pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal polypeptide/growth hormone-releasing hormone/secretin family in testis.

Authors:  Min Li; Akira Arimura
Journal:  Endocrine       Date:  2003-04       Impact factor: 3.633
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