Literature DB >> 32748142

Changes in Histophysiology of the Adrenal Medulla in Rats after Prenatal and Postnatal Exposure to Endocrine Disruptor DDT.

N V Yaglova1, E P Timokhina2, V V Yaglov2, S S Obernikhin2, S V Nazimova2, D A Tsomartova2.   

Abstract

We studied histophysiology of the adrenal medulla in adult (70-day-old) male Wistar rats developmentally exposed to low doses of endocrine disruptor DDT. It was found that exposure to DDT during the prenatal and postnatal ontogeny decelerated the development of the adrenal medulla and reduced the synthesis of tyrosine hydroxylase, the rate-liming enzyme of catecholamine synthesis, in chromaffin cells, which led to a decrease in epinephrine secretion into the blood.

Entities:  

Keywords:  DDT; catecholamines; endocrine disruptor; epinephrine; tyrosine hydroxylase

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Year:  2020        PMID： 32748142     DOI： 10.1007/s10517-020-04895-6

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  3 in total

1.  Mechanisms of Suppression of Epinephrine Production in Rats by Low-Dose Developmental Exposure to DDT.

Authors:  N V Yaglova; S S Obernikhin; D A Tsomartova; V V Yaglov; S V Nazimova; E P Timokhina; E S Tsomartova
Journal:  Bull Exp Biol Med       Date:  2022-05-27       Impact factor: 0.804

Review 2.  Endocrine disrupting chemicals: effects on pituitary, thyroid and adrenal glands.

Authors:  Filippo Egalini; Lorenzo Marinelli; Mattia Rossi; Giovanna Motta; Nunzia Prencipe; Ruth Rossetto Giaccherino; Loredana Pagano; Silvia Grottoli; Roberta Giordano
Journal:  Endocrine       Date:  2022-05-23       Impact factor: 3.925

Review 3.  Impact of Chemical Endocrine Disruptors and Hormone Modulators on the Endocrine System.

Authors:  Valentina Guarnotta; Roberta Amodei; Francesco Frasca; Antonio Aversa; Carla Giordano
Journal:  Int J Mol Sci       Date:  2022-05-20       Impact factor: 6.208
  3 in total

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