Karin Trimmel1,2,3, Lorenzo Caciagli4,5, Fenglai Xiao4,5, Louis A van Graan4,5, Matthias J Koepp4,5, Pamela J Thompson4,5, John S Duncan4,5. 1. Epilepsy Society MRI Unit, Chalfont Centre for Epilepsy, Chalfont St Peter, SL9 0LR, UK. k.trimmel@ucl.ac.uk. 2. Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, Queen Square, London, WC1N 3BG, UK. k.trimmel@ucl.ac.uk. 3. Department of Neurology, Medical University of Vienna, 1090, Vienna, Austria. k.trimmel@ucl.ac.uk. 4. Epilepsy Society MRI Unit, Chalfont Centre for Epilepsy, Chalfont St Peter, SL9 0LR, UK. 5. Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Abstract
OBJECTIVE: To investigate alterations of language networks and their relation to impaired naming performance in temporal lobe epilepsy (TLE) using functional MRI. METHODS: Seventy-two adult TLE patients (41 left) and 36 controls were studied with overt auditory and picture naming fMRI tasks to assess temporal lobe language areas, and a covert verbal fluency task to probe frontal lobe language regions. Correlation of fMRI activation with clinical naming scores, and alteration of language network patterns in relation to epilepsy duration, age at onset and seizure frequency, were investigated with whole-brain multiple regression analyses. RESULTS: Auditory and picture naming fMRI activated the left posterior temporal lobe, and stronger activation correlated with better clinical naming scores. Verbal fluency MRI mainly activated frontal lobe regions. In left and right TLE, a later age of epilepsy onset related to stronger temporal lobe activations, while earlier age of onset was associated with impaired deactivation of extratemporal regions. In left TLE patients, longer disease duration and higher seizure frequency were associated with reduced deactivation. Frontal lobe language networks were unaffected by disease characteristics. CONCLUSIONS: While frontal lobe language regions appear spared, temporal lobe language areas are susceptible to dysfunction and reorganisation, particularly in left TLE. Early onset and long duration of epilepsy, and high seizure frequency, were associated with compromised activation and deactivation patterns of task-associated regions, which might account for impaired naming performance in individuals with TLE.
OBJECTIVE: To investigate alterations of language networks and their relation to impaired naming performance in temporal lobe epilepsy (TLE) using functional MRI. METHODS: Seventy-two adult TLEpatients (41 left) and 36 controls were studied with overt auditory and picture naming fMRI tasks to assess temporal lobe language areas, and a covert verbal fluency task to probe frontal lobe language regions. Correlation of fMRI activation with clinical naming scores, and alteration of language network patterns in relation to epilepsy duration, age at onset and seizure frequency, were investigated with whole-brain multiple regression analyses. RESULTS: Auditory and picture naming fMRI activated the left posterior temporal lobe, and stronger activation correlated with better clinical naming scores. Verbal fluency MRI mainly activated frontal lobe regions. In left and right TLE, a later age of epilepsy onset related to stronger temporal lobe activations, while earlier age of onset was associated with impaired deactivation of extratemporal regions. In left TLEpatients, longer disease duration and higher seizure frequency were associated with reduced deactivation. Frontal lobe language networks were unaffected by disease characteristics. CONCLUSIONS: While frontal lobe language regions appear spared, temporal lobe language areas are susceptible to dysfunction and reorganisation, particularly in left TLE. Early onset and long duration of epilepsy, and high seizure frequency, were associated with compromised activation and deactivation patterns of task-associated regions, which might account for impaired naming performance in individuals with TLE.
Authors: M E Raichle; A M MacLeod; A Z Snyder; W J Powers; D A Gusnard; G L Shulman Journal: Proc Natl Acad Sci U S A Date: 2001-01-16 Impact factor: 11.205
Authors: Gloria G Gonzálvez; Karin Trimmel; Anja Haag; Louis A van Graan; Matthias J Koepp; Pamela J Thompson; John S Duncan Journal: Epilepsy Res Date: 2016-10-29 Impact factor: 3.045
Authors: Karin Trimmel; Andre L van Graan; Lorenzo Caciagli; Anja Haag; Matthias J Koepp; Pamela J Thompson; John S Duncan Journal: Brain Date: 2018-08-01 Impact factor: 13.501
Authors: Silvia B Bonelli; Rob Powell; Pamela J Thompson; Mahinda Yogarajah; Niels K Focke; Jason Stretton; Christian Vollmar; Mark R Symms; Cathy J Price; John S Duncan; Matthias J Koepp Journal: Epilepsy Res Date: 2011-05-18 Impact factor: 3.045
Authors: Silvia B Bonelli; Pamela J Thompson; Mahinda Yogarajah; Christian Vollmar; Robert H W Powell; Mark R Symms; Andrew W McEvoy; Caroline Micallef; Matthias J Koepp; John S Duncan Journal: Epilepsia Date: 2012-03-16 Impact factor: 5.864
Authors: Clarissa Lin Yasuda; Maria Centeno; Christian Vollmar; Jason Stretton; Mark Symms; Fernando Cendes; Mitul A Mehta; Pamela Thompson; John S Duncan; Matthias J Koepp Journal: Epilepsy Res Date: 2013-01-17 Impact factor: 3.045
Authors: Karin Trimmel; Sjoerd B Vos; Lorenzo Caciagli; Fenglai Xiao; Louis A van Graan; Gavin P Winston; Matthias J Koepp; Pamela J Thompson; John S Duncan Journal: Epilepsia Date: 2021-10-12 Impact factor: 5.864
Authors: Caroline Reindl; Anna-Lena Allgäuer; Benedict A Kleiser; Müjgan Dogan Onugoren; Johannes D Lang; Tamara M Welte; Jenny Stritzelberger; Klemens Winder; Michael Schwarz; Stephanie Gollwitzer; Regina Trollmann; Julie Rösch; Arnd Doerfler; Karl Rössler; Sebastian Brandner; Dominik Madžar; Frank Seifert; Stefan Rampp; Hajo M Hamer; Katrin Walther Journal: Neuroimage Clin Date: 2022-07-29 Impact factor: 4.891