| Literature DB >> 32747259 |
Bulei Wang1, Hui Zhang2, Lijun Chen1, Zeyuan Mi1, Yan Xu1, Guangming Zhao1, Shuai Liu1, Hui Lei3, Zhezhi Wang1, Junfeng Niu4.
Abstract
In this study, a water-soluble polysaccharide (BSP) was extracted and purified from pseudobulb of Bletilla striata. The preliminary structure and gastroprotective activity of BSP were analyzed. Results indicate that BSP is a glucomannan with a molar ratio of 7.45:2.55 (Man:Glc), and its molecular weight is approximately 1.7 × 105 Da. BSP displayed outstanding protective action against ethanol-induced GES-1 cell injury in vitro, as well as, excellent gastroprotective activity in vivo. Especially, a high-dose of BSP (100 mg/kg) could reduce the ulcer index of the gastric mucosa and increase the percentage of ulcer inhibition, which possibly caused by enhancing the antioxidant capacity and inhibiting the apoptotic pathway in gastric tissue. Interestingly, BSP exhibited a comparative gastroprotective activity to that of positive control (omeprazole). In summary, our results indicated that BSP could be considered as a potential supplement for the prevention of gastric injury.Entities:
Keywords: Antioxidant activity; Bletilla striata; Gastroprotective activity; Polysaccharides
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Year: 2020 PMID： 32747259 DOI： 10.1016/j.carbpol.2020.116620
Source DB: PubMed Journal: Carbohydr Polym ISSN： 0144-8617 Impact factor: 9.381