Literature DB >> 32746643

Inhibitory activity against carbonic anhydrase IX and XII as a candidate selection criterion in the development of new anticancer agents.

Mikhail Krasavin1, Stanislav Kalinin1, Tatiana Sharonova1, Claudiu T Supuran2.   

Abstract

Analysis of the literature data reveals that while inhibition of cancer-related carbonic anhydrase IX and XII isoforms continues to be an important enrichment factor for designing anticancer agent development libraries, exclusive reliance on the in vitro inhibition of these two recombinant isozymes in nominating candidate compounds for evaluation of their effects on cancer cells may lead not only to identifying numerous compounds devoid of the desired cellular efficacy but also to overlooking many promising candidates which may not display the best potency in biochemical inhibition assay. However, SLC-0111, now in phase Ib/II clinical trials, was developed based on the excellent agreement between the in vitro, in vivo and more recently, in-patient data.

Entities:  

Keywords:  Carbonic anhydrase inhibitors; anticancer agents; cancer-related IX and XII isoforms; enrichment factor; screening funnel

Mesh：

Substances：

Year:  2020        PMID： 32746643      PMCID： PMC7470080          DOI： 10.1080/14756366.2020.1801674

Source DB:  PubMed          Journal:  J Enzyme Inhib Med Chem        ISSN： 1475-6366            Impact factor:   5.051


  69 in total

1.  6-Substituted sulfocoumarins are selective carbonic anhdydrase IX and XII inhibitors with significant cytotoxicity against colorectal cancer cells.

Authors:  Aiga Grandane; Muhammet Tanc; Lorenzo Di Cesare Mannelli; Fabrizio Carta; Carla Ghelardini; Raivis Žalubovskis; Claudiu T Supuran
Journal:  J Med Chem       Date:  2015-04-23       Impact factor: 7.446

Review 2.  Drug-target residence time and its implications for lead optimization.

Authors:  Robert A Copeland; David L Pompliano; Thomas D Meek
Journal:  Nat Rev Drug Discov       Date:  2006-08-04       Impact factor: 84.694

3.  Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies.

Authors:  Wagdy M Eldehna; Mahmoud F Abo-Ashour; Alessio Nocentini; Paola Gratteri; Ibrahim H Eissa; Mohamed Fares; Omnia E Ismael; Hazem A Ghabbour; Mahmoud M Elaasser; Hatem A Abdel-Aziz; Claudiu T Supuran
Journal:  Eur J Med Chem       Date:  2017-08-01       Impact factor: 6.514

4.  Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity.

Authors:  Damiano Tanini; Lorenzo Ricci; Antonella Capperucci; Lorenzo Di Cesare Mannelli; Carla Ghelardini; Thomas S Peat; Fabrizio Carta; Andrea Angeli; Claudiu T Supuran
Journal:  Eur J Med Chem       Date:  2019-08-05       Impact factor: 6.514

5.  Application of hydrazino and hydrazido linkers to connect benzenesulfonamides with hydrophilic/phobic tails for targeting the middle region of human carbonic anhydrases active site: Selective inhibitors of hCA IX.

Authors:  Heba Abdelrasheed Allam; Samar H Fahim; Mahmoud F Abo-Ashour; Alessio Nocentini; Mohamed E Elbakry; Mohamed A Abdelrahman; Wagdy M Eldehna; Hany S Ibrahim; Claudiu T Supuran
Journal:  Eur J Med Chem       Date:  2019-06-28       Impact factor: 6.514

6.  Synthesis, biological activity and multiscale molecular modeling studies of bis-coumarins as selective carbonic anhydrase IX and XII inhibitors with effective cytotoxicity against hepatocellular carcinoma.

Authors:  Belma Zengin Kurt; Aydan Dag; Berna Doğan; Serdar Durdagi; Andrea Angeli; Alessio Nocentini; Claudiu T Supuran; Fatih Sonmez
Journal:  Bioorg Chem       Date:  2019-03-07       Impact factor: 5.275

7.  Evaluation of the anticancer potential of a sulphonamide carbonic anhydrase IX inhibitor on cervical cancer cells.

Authors:  Ismail Koyuncu; Yasin Tülüce; Hewa Slahaddin Qadir; Mustafa Durgun; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2019-12       Impact factor: 5.051

Review 8.  The role of carbonic anhydrase IX in cancer development: links to hypoxia, acidosis, and beyond.

Authors:  Silvia Pastorekova; Robert J Gillies
Journal:  Cancer Metastasis Rev       Date:  2019-06       Impact factor: 9.264

Review 9.  Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer.

Authors:  Johanna Chiche; M Christiane Brahimi-Horn; Jacques Pouysségur
Journal:  J Cell Mol Med       Date:  2009-12-08       Impact factor: 5.310

10.  Selective inhibition of carbonic anhydrase-IX by sulphonamide derivatives induces pH and reactive oxygen species-mediated apoptosis in cervical cancer HeLa cells.

Authors:  Ismail Koyuncu; Ataman Gonel; Abdurrahim Kocyigit; Ebru Temiz; Mustafa Durgun; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051
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  4 in total

Review 1.  Targeting carbonic anhydrase IX and XII isoforms with small molecule inhibitors and monoclonal antibodies.

Authors:  Mateusz Kciuk; Adrianna Gielecińska; Somdutt Mujwar; Mariusz Mojzych; Beata Marciniak; Rafał Drozda; Renata Kontek
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.756

2.  Antiproliferative effects of sulphonamide carbonic anhydrase inhibitors C18, SLC-0111 and acetazolamide on bladder, glioblastoma and pancreatic cancer cell lines.

Authors:  Silvia Mussi; Sara Rezzola; Paola Chiodelli; Alessio Nocentini; Claudiu T Supuran; Roberto Ronca
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.051

3.  2-Aminobenzoxazole-appended coumarins as potent and selective inhibitors of tumour-associated carbonic anhydrases.

Authors:  Alma Fuentes-Aguilar; Penélope Merino-Montiel; Sara Montiel-Smith; Socorro Meza-Reyes; José Luis Vega-Báez; Adrián Puerta; Miguel X Fernandes; José M Padrón; Andrea Petreni; Alessio Nocentini; Claudiu T Supuran; Óscar López; José G Fernández-Bolaños
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.051

4.  Squaramide-Tethered Sulfonamides and Coumarins: Synthesis, Inhibition of Tumor-Associated CAs IX and XII and Docking Simulations.

Authors:  Giulia Arrighi; Adrián Puerta; Andrea Petrini; Francisco J Hicke; Alessio Nocentini; Miguel X Fernandes; José M Padrón; Claudiu T Supuran; José G Fernández-Bolaños; Óscar López
Journal:  Int J Mol Sci       Date:  2022-07-12       Impact factor: 6.208
  4 in total

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