Detection and Localization of Ultrasound Scatterers Using Convolutional Neural Networks.

Delay-and-sum (DAS) beamforming is unable to identify individual scatterers when their density is so high that their point spread functions overlap. This paper proposes a convolutional neural network (CNN)-based method to detect and localize high-density scatterers, some of which are closer than the resolution limit of delay-and-sum (DAS) beamforming. A CNN was designed to take radio frequency channel data and return non-overlapping Gaussian confidence maps. The scatterer positions were estimated from the confidence maps by identifying local maxima. On simulated test sets, the CNN method with three plane waves achieved a precision of 1.00 and a recall of 0.91. Localization uncertainties after excluding outliers were ±46 [Formula: see text] (outlier ratio: 4%) laterally and ±26 [Formula: see text] (outlier ratio: 1%) axially. To evaluate the proposed method on measured data, two phantoms containing cavities were 3-D printed and imaged. For the phantom study, the training data were modified according to the physical properties of the phantoms and a new CNN was trained. On an uniformly spaced scatterer phantom, a precision of 0.98 and a recall of 1.00 were achieved with the localization uncertainties of ±101 [Formula: see text] (outlier ratio: 1%) laterally and ±37 [Formula: see text] (outlier ratio: 1%) axially. On a randomly spaced scatterer phantom, a precision of 0.59 and a recall of 0.63 were achieved. The localization uncertainties were ±132 [Formula: see text] (outlier ratio: 0%) laterally and ±44 [Formula: see text] with a bias of 22 [Formula: see text] (outlier ratio: 0%) axially. This method can potentially be extended to detect highly concentrated microbubbles in order to shorten data acquisition times of super-resolution ultrasound imaging.