Emma K Stapp1, Stacey C Williams2, Luther G Kalb3, Calliope B Holingue3, Kathryn Van Eck4, Elizabeth D Ballard5, Kathleen R Merikangas6, Joseph J Gallo2. 1. Genetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: emma.stapp@nih.gov. 2. Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. 3. Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Kennedy Krieger Institute, Baltimore, MD, USA. 4. Kennedy Krieger Institute, Baltimore, MD, USA. 5. Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA. 6. Genetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA.
Abstract
OBJECTIVE: Mood disorders, child maltreatment, and medical morbidity are associated with enormous public health burden and individual suffering. The effect of mood disorders on medical morbidity, accounting for child maltreatment, has not been studied prospectively in a large, representative sample of community-dwelling US adults. This study tested the effects of mood disorders and child maltreatment on medical morbidity, and variation by subtypes. METHODS: Participants were noninstitutionalized US adults in the National Epidemiologic Survey on Alcohol and Related Conditions (N = 43,093 wave 1, N = 34,653 wave 2). Mood disorders included lifetime DSM-IV episodes of depression, dysthymia, mania, or hypomania. Child maltreatment was defined as sexual, physical, or emotional abuse, or physical or emotional neglect before age 18. Survey-weighted zero-inflated poisson regression was used to study effects on medical morbidity, a summary score of 11 self-reported medical conditions. Results were adjusted for age, sex, ethnicity/race, income, substance use disorders, smoking, and obesity. RESULTS: Mood disorders and child maltreatment additively associated with medical morbidity at study entry and three years later, with similar magnitude as obesity and smoking. Mania/hypomania (incidence rate ratio [IRR] 1.06, 95% CI 1.01-1.10) and child sexual (IRR 1.08, 95% CI 1.04-1.11) and emotional (IRR 1.05, 95% CI 1.01-1.10) abuse were associated with higher medical morbidity longitudinally. CONCLUSIONS: Child maltreatment is common, and its long-range negative effect on medical morbidity underscores the importance of trauma-informed care, and consideration of early life exposures. History of mania/hypomania should be considered in medical practice, and physical health must be emphasized in mental health care. Published by Elsevier Inc.
OBJECTIVE: Mood disorders, child maltreatment, and medical morbidity are associated with enormous public health burden and individual suffering. The effect of mood disorders on medical morbidity, accounting for child maltreatment, has not been studied prospectively in a large, representative sample of community-dwelling US adults. This study tested the effects of mood disorders and child maltreatment on medical morbidity, and variation by subtypes. METHODS: Participants were noninstitutionalized US adults in the National Epidemiologic Survey on Alcohol and Related Conditions (N = 43,093 wave 1, N = 34,653 wave 2). Mood disorders included lifetime DSM-IV episodes of depression, dysthymia, mania, or hypomania. Child maltreatment was defined as sexual, physical, or emotional abuse, or physical or emotional neglect before age 18. Survey-weighted zero-inflated poisson regression was used to study effects on medical morbidity, a summary score of 11 self-reported medical conditions. Results were adjusted for age, sex, ethnicity/race, income, substance use disorders, smoking, and obesity. RESULTS: Mood disorders and child maltreatment additively associated with medical morbidity at study entry and three years later, with similar magnitude as obesity and smoking. Mania/hypomania (incidence rate ratio [IRR] 1.06, 95% CI 1.01-1.10) and child sexual (IRR 1.08, 95% CI 1.04-1.11) and emotional (IRR 1.05, 95% CI 1.01-1.10) abuse were associated with higher medical morbidity longitudinally. CONCLUSIONS: Child maltreatment is common, and its long-range negative effect on medical morbidity underscores the importance of trauma-informed care, and consideration of early life exposures. History of mania/hypomania should be considered in medical practice, and physical health must be emphasized in mental health care. Published by Elsevier Inc.
Authors: K R Merikangas; L Cui; L Heaton; E Nakamura; C Roca; J Ding; H Qin; W Guo; Y Y Shugart; Y Yao-Shugart; C Zarate; J Angst Journal: Mol Psychiatry Date: 2013-10-15 Impact factor: 15.992
Authors: Katherine M Keyes; Nicholas R Eaton; Robert F Krueger; Katie A McLaughlin; Melanie M Wall; Bridget F Grant; Deborah S Hasin Journal: Br J Psychiatry Date: 2011-12-08 Impact factor: 9.319
Authors: Jeffrey L Birk; Ian M Kronish; Nathalie Moise; Louise Falzon; Sunmoo Yoon; Karina W Davidson Journal: Health Psychol Date: 2019-04-22 Impact factor: 4.267
Authors: B Stubbs; L Eggermont; A J Mitchell; M De Hert; C U Correll; A Soundy; S Rosenbaum; D Vancampfort Journal: Acta Psychiatr Scand Date: 2014-08-06 Impact factor: 6.392
Authors: Kathleen R Merikangas; Hagop S Akiskal; Jules Angst; Paul E Greenberg; Robert M A Hirschfeld; Maria Petukhova; Ronald C Kessler Journal: Arch Gen Psychiatry Date: 2007-05
Authors: Liz Forty; Anna Ulanova; Lisa Jones; Ian Jones; Katherine Gordon-Smith; Christine Fraser; Anne Farmer; Peter McGuffin; Cathryn M Lewis; Georgina M Hosang; Margarita Rivera; Nick Craddock Journal: Br J Psychiatry Date: 2014-10-30 Impact factor: 9.319
Authors: Flore Moulin; Mehdi Gholam; Marie-Pierre F Strippoli; Enrique Castelao; Kathleen R Merikangas; Emma K Stapp; Pierre Marquet; Jean-Michel Aubry; Kerstin J Plessen; Francesca Di Giacomo; Jennifer Glaus; Giorgio Pistis; Benjamin Lavigne; Julien Elowe; Setareh Ranjbar; Martin Preisig; Caroline L Vandeleur Journal: Int J Bipolar Disord Date: 2022-04-06