| Literature DB >> 32744957 |
Reyaz Hassan Mir1, Abdul Jalil Shah1, Roohi Mohi-Ud-Din2, Faheem Hyder Pottoo3, Mohd Akbar Dar1, Sanjay M Jachak4, Mubashir Hussain Masoodi1.
Abstract
Alzheimer's disease (AD) is a chronic neurodegenerative brain disorder characterized by memory impairment, dementia, and oxidative stress in elderly people. Currently, only a few drugs are available in the market with various adverse effects. Therefore, to develop new drugs with protective action against the disease, research is turning to the identification of plant products as a remedy. Natural compounds with anti-inflammatory activity could be good candidates for developing effective therapeutic strategies. Phytochemicals, including Curcumin, Resveratrol, Quercetin, Huperzine-A, Rosmarinic acid, genistein, obovatol, and Oxyresvertarol, were reported molecules for the treatment of AD. Several alkaloids, such as galantamine, oridonin, glaucocalyxin B, tetrandrine, berberine and anatabine, have been shown anti-inflammatory effects in AD models in vitro as well as in-vivo. In conclusion, natural products from plants represent interesting candidates for the treatment of AD. This review highlights the potential of specific compounds from natural products along with their synthetic derivatives to counteract AD in the CNS. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Entities:
Keywords: Alzheimer's disease; Amyloid precursor protein Flavonoids; BACE-1; Microglia; Phytochemicals.zzm321990; natural products
Year: 2020 PMID： 32744957 DOI： 10.2174/0929867327666200730213215
Source DB: PubMed Journal: Curr Med Chem ISSN： 0929-8673 Impact factor: 4.530