Yao Lu1, Yuan Wang1, Ting Zhang1, Guiquan Wang2, Yaqiong He1, Steven R Lindheim3, Zhangsheng Yu4, Yun Sun5. 1. Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, People's Republic of China. 2. Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Zhejiang, People's Republic of China. 3. Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China; Department of Obstetrics and Gynecology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio. 4. Department of Bioinformatics and Biostatistics, Shanghai Jiao Tong University -Yale Joint Center for Biostatistics, Shanghai Jiao Tong University, Shanghai, People's Republic of China. 5. Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, People's Republic of China. Electronic address: syun163@163.com.
Abstract
OBJECTIVE: To evaluate the impact of oral contraceptives (OC) on live birth rate (LBR) following a fresh embryo transfer and cumulative live birth rate (cLBR) in normal ovulatory women undergoing in vitro fertilization (IVF). DESIGN: Retrospective cohort study. SETTING: Reproductive center. PATIENTS: A total of 3,110 normo-ovulatory women aged 20-40 years undergoing IVF either using or not using OC pretreatment in their first autologous cycle. INTERVENTION(S): Patients initiated gonadotropins for their IVF cycle either after a spontaneous menses or following OC pretreatment, which was at the discretion of the provider or according to patients preference. MAIN OUTCOME MEASURE(S): The primary outcomes were LBR after fresh transfer (fLBR) and cLBR. RESULTS: fLBR was significantly lower in women using OC compared to those not (42.6% vs. 52.8%). Although LBR after frozen embryo transfer cycles were similar (42.7% vs. 41.1%), cLBR was significantly lower in women using OC (62.8% vs. 67.6%). Multivariate logistic and COX regression analysis adjusting for baseline characteristics demonstrated that IVF cycle synchronization with OC was significantly associated with a lower fLBR (adjusted odds ratio 0.73, 95% confidence interval 0.62-0.86) and cLBR (adjusted hazard ratio 0.89, 95% confidence interval 0.80-0.98). CONCLUSIONS: Pretreatment OC use is associated with a reduction in fLBR and cLBR.
OBJECTIVE: To evaluate the impact of oral contraceptives (OC) on live birth rate (LBR) following a fresh embryo transfer and cumulative live birth rate (cLBR) in normal ovulatory women undergoing in vitro fertilization (IVF). DESIGN: Retrospective cohort study. SETTING: Reproductive center. PATIENTS: A total of 3,110 normo-ovulatory women aged 20-40 years undergoing IVF either using or not using OC pretreatment in their first autologous cycle. INTERVENTION(S): Patients initiated gonadotropins for their IVF cycle either after a spontaneous menses or following OC pretreatment, which was at the discretion of the provider or according to patients preference. MAIN OUTCOME MEASURE(S): The primary outcomes were LBR after fresh transfer (fLBR) and cLBR. RESULTS:fLBR was significantly lower in women using OC compared to those not (42.6% vs. 52.8%). Although LBR after frozen embryo transfer cycles were similar (42.7% vs. 41.1%), cLBR was significantly lower in women using OC (62.8% vs. 67.6%). Multivariate logistic and COX regression analysis adjusting for baseline characteristics demonstrated that IVF cycle synchronization with OC was significantly associated with a lower fLBR (adjusted odds ratio 0.73, 95% confidence interval 0.62-0.86) and cLBR (adjusted hazard ratio 0.89, 95% confidence interval 0.80-0.98). CONCLUSIONS: Pretreatment OC use is associated with a reduction in fLBR and cLBR.
Authors: Hongbo Wu; Fu Wei; Weihong Tan; Mei Dong; Ying Tan; Xiqian Zhang; Ge Song; Liling Liu Journal: Medicine (Baltimore) Date: 2022-10-07 Impact factor: 1.817