Shenshen Zhang1, Lihong Wu1, Boyu Zhang1, Yuanrong Zhu1, Yinguang Fan2, Qiao Wang1, Xiangpeng Hu1, Yanghua Tian3. 1. Digestive Department, The Second Affiliated Hospital of Anhui Medical University , Hefei, China. 2. Department of Epidemiology and Biostatistics, School of Public Health of Anhui Medical University , Hefei, China. 3. Department of Neurology, The First Affiliated Hospital of Anhui Medical University , Hefei, China.
Abstract
INTRODUCTION: The cognitive processing in patients with functional dyspepsia (FD) has not been well established. Decision-making is an important component of cognitive function. Most brain regions involved in decision-making are abnormal in FD patients. This study aimed to investigate the decision-making under ambiguity and risk in FD patients. METHODS: We recruited 40 FD patients meeting Rome III criteria and 40 healthy controls (HCs) matched for age, sex, marital status, and education level. The Hamilton Anxiety Scale (HAMA) and the 17-item Hamilton Depression Scale (HAMD-17) were used to evaluate their anxiety and depression emotions. The Iowa Gambling Task (IGT) and Game of Dice Task (GDT) were used to evaluate decision-making under ambiguity and risk, respectively. Helicobacter pylori status, disease duration, dyspeptic symptom score, and the Nepean Dyspepsia Life Quality Index (NDLQI) were obtained from all patients. RESULTS: In IGT, FD patients had a lower total net score, chose more adverse choices, and showed a slower response to change their behavior than HCs. However, there was no significant difference in the net score of the first 2 blocks between the two groups. In GDT, FD patients had a lower total net score, higher risk score, and lower use of negative feedback than HCs. In addition, FD patients showed better GDT performance than those without early satiation. CONCLUSIONS: FD patients showed impaired decision-making under risk. The deficiency might be related to dyspeptic symptoms of FD patients.
INTRODUCTION: The cognitive processing in patients with functional dyspepsia (FD) has not been well established. Decision-making is an important component of cognitive function. Most brain regions involved in decision-making are abnormal in FDpatients. This study aimed to investigate the decision-making under ambiguity and risk in FDpatients. METHODS: We recruited 40 FDpatients meeting Rome III criteria and 40 healthy controls (HCs) matched for age, sex, marital status, and education level. The Hamilton Anxiety Scale (HAMA) and the 17-item Hamilton Depression Scale (HAMD-17) were used to evaluate their anxiety and depression emotions. The Iowa Gambling Task (IGT) and Game of Dice Task (GDT) were used to evaluate decision-making under ambiguity and risk, respectively. Helicobacter pylori status, disease duration, dyspeptic symptom score, and the Nepean Dyspepsia Life Quality Index (NDLQI) were obtained from all patients. RESULTS: In IGT, FDpatients had a lower total net score, chose more adverse choices, and showed a slower response to change their behavior than HCs. However, there was no significant difference in the net score of the first 2 blocks between the two groups. In GDT, FDpatients had a lower total net score, higher risk score, and lower use of negative feedback than HCs. In addition, FDpatients showed better GDT performance than those without early satiation. CONCLUSIONS:FDpatients showed impaired decision-making under risk. The deficiency might be related to dyspeptic symptoms of FDpatients.
Entities:
Keywords:
Functional dyspepsia; Game of Dice Task; Iowa Gambling Task; decision-making; dyspeptic symptoms