Hyun-Seo Ahn1, Hee Chul Yu2, Hyo Sung Kwak3, Sung-Hong Park4. 1. Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea. 2. Department of Surgery, Jeonbuk National University Medical School and Hospital, Jeonju, South Korea. 3. Department of Radiology and Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea. Electronic address: kwak8140@jbnu.ac.kr. 4. Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea. Electronic address: sunghongpark@kaist.ac.kr.
Abstract
PURPOSE: To investigate technical issues for implementing pseudo-continuous arterial spin labeling (pCASL) for renal perfusion measurements in transplanted kidney patients (TK) in the early postoperative recovery phase. METHODS: Eleven subjects were scanned: TK (N = 4, 42 ± 8.1Y) and normal volunteers (NV) (N = 7, 25 ± 3Y). In 3.0 T clinical MRI, pCASL with a 2D balanced steady-state free precession readout was applied with four different post-labeling delays: 0.5/1.0/1.5/2.0 s. Perfusion images were acquired with and without background suppression and processed with and without registration for comparison. Renal blood flow (RBF) and arterial transit time (ATT) values were calculated from each pixel of images. The F-test, Wilcoxon signed-rank test, and Wilcoxon rank-sum test were used for statistical analyses. RESULTS: Background suppression decreased signal variations for both NV and TK. Registration suppressed effects of kidney motion for NV, which was not critical for TK. The renal cortex showed greater perfusion than the renal medulla in both NV and TK(p < 0.01). TK showed greater renal perfusion than NV(p < 0.05). Cortical and medullary RBF values were 271.8 ± 43.5, 119.1 ± 15.1 ml/100 g/min for NV and 358.3 ± 36.4, 141.0 ± 11.5 ml/100 g/min for TK. TK showed longer ATT values than NV(p < 0.01). ATT values in the cortex and medulla were 641 ± 141 and 746 ± 150 ms for NV and 919 ± 49 and 935 ± 81 ms for TK. CONCLUSIONS: We demonstrated that although there is no discernible motion of the transplanted kidney, background suppression is necessary to suppress signal fluctuations in renal perfusion measurements. Also, relatively high RBF and long ATT values were observed in the transplanted kidneys in the early postoperative recovery phase, which requires further longitudinal studies.
PURPOSE: To investigate technical issues for implementing pseudo-continuous arterial spin labeling (pCASL) for renal perfusion measurements in transplanted kidney patients (TK) in the early postoperative recovery phase. METHODS: Eleven subjects were scanned: TK (N = 4, 42 ± 8.1Y) and normal volunteers (NV) (N = 7, 25 ± 3Y). In 3.0 T clinical MRI, pCASL with a 2D balanced steady-state free precession readout was applied with four different post-labeling delays: 0.5/1.0/1.5/2.0 s. Perfusion images were acquired with and without background suppression and processed with and without registration for comparison. Renal blood flow (RBF) and arterial transit time (ATT) values were calculated from each pixel of images. The F-test, Wilcoxon signed-rank test, and Wilcoxon rank-sum test were used for statistical analyses. RESULTS: Background suppression decreased signal variations for both NV and TK. Registration suppressed effects of kidney motion for NV, which was not critical for TK. The renal cortex showed greater perfusion than the renal medulla in both NV and TK(p < 0.01). TK showed greater renal perfusion than NV(p < 0.05). Cortical and medullary RBF values were 271.8 ± 43.5, 119.1 ± 15.1 ml/100 g/min for NV and 358.3 ± 36.4, 141.0 ± 11.5 ml/100 g/min for TK. TK showed longer ATT values than NV(p < 0.01). ATT values in the cortex and medulla were 641 ± 141 and 746 ± 150 ms for NV and 919 ± 49 and 935 ± 81 ms for TK. CONCLUSIONS: We demonstrated that although there is no discernible motion of the transplanted kidney, background suppression is necessary to suppress signal fluctuations in renal perfusion measurements. Also, relatively high RBF and long ATT values were observed in the transplanted kidneys in the early postoperative recovery phase, which requires further longitudinal studies.
Authors: Liangdong Zhou; Qihao Zhang; Pascal Spincemaille; Thanh D Nguyen; John Morgan; Weiying Dai; Yi Li; Ajay Gupta; Martin R Prince; Yi Wang Journal: Magn Reson Med Date: 2020-11-18 Impact factor: 4.668