S Bonifazi1, C Passamonti2, S Vecchioni3, R Trignani3, P P Martorano4, V Durazzi5, S Lattanzi5, F Mancini6, R A Ricciuti6. 1. Unit of Hospital Psychology, Azienda Ospedaliero-Universitaria Ospedali Riuniti di Ancona, Italy. Electronic address: silvia.bonifazi@ospedaliriuniti.marche.it. 2. Unit of Hospital Psychology, Azienda Ospedaliero-Universitaria Ospedali Riuniti di Ancona, Italy. 3. Division of Neurosurgery, Azienda Ospedaliero-Universitaria Ospedali Riuniti di Ancona Italy. 4. Unit of Neuro-Anesthesia, Azienda Ospedaliero-Universitaria Ospedali Riuniti di Ancona, Italy. 5. Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University Ancona, Italy. 6. Division of Neurosurgery, Ospedale Belcolle, ASL Viterbo, Italy.
Abstract
BACKGROUND: Preservation of language and cognition is crucial in glioma surgery, as they are crucial aspects of daily life functioning. Several studies claimed that awake surgery in eloquent areas is demanded in low and high-grade gliomas. Cognitive and language outcome has been less investigated in high-grade gliomas compared to low-grade. METHOD: We analyzed the neuropsychological and neuro-oncological outcome of nineteen patients (from a cohort of forty patients) who underwent fully awake surgery for resection of malignant tumors located in eloquent areas. RESULTS: Post-surgery, linguistic functions were unchanged in 80 % of patients. Slight impairments in memory and executive functions were observed in about 50 % of patients. Survival rate at one year follow-up was 89 %. Results showed that awake procedure is safe, well tolerated and related with good linguistic outcome similar to low-grade gliomas. The majority of patients reported a good outcome in term of quality of life. CONCLUSIONS: Our results confirm that awake surgery is associated to good cognitive and linguistic clinical outcome also in malignant tumors.
BACKGROUND: Preservation of language and cognition is crucial in glioma surgery, as they are crucial aspects of daily life functioning. Several studies claimed that awake surgery in eloquent areas is demanded in low and high-grade gliomas. Cognitive and language outcome has been less investigated in high-grade gliomas compared to low-grade. METHOD: We analyzed the neuropsychological and neuro-oncological outcome of nineteen patients (from a cohort of forty patients) who underwent fully awake surgery for resection of malignant tumors located in eloquent areas. RESULTS: Post-surgery, linguistic functions were unchanged in 80 % of patients. Slight impairments in memory and executive functions were observed in about 50 % of patients. Survival rate at one year follow-up was 89 %. Results showed that awake procedure is safe, well tolerated and related with good linguistic outcome similar to low-grade gliomas. The majority of patients reported a good outcome in term of quality of life. CONCLUSIONS: Our results confirm that awake surgery is associated to good cognitive and linguistic clinical outcome also in malignant tumors.
Authors: Katharina Rosengarth; Delin Pai; Frank Dodoo-Schittko; Katharina Hense; Teele Tamm; Christian Ott; Ralf Lürding; Elisabeth Bumes; Mark W Greenlee; Karl Michael Schebesch; Nils Ole Schmidt; Christian Doenitz Journal: J Clin Med Date: 2021-02-08 Impact factor: 4.241