Miguel Germán Borda1,2,3, Dag Aarsland1,4, Diego Alejandro Tovar-Rios5,6, Lasse M Giil7, Clive Ballard8, Maria Camila Gonzalez1,9, Kolbjørn Brønnick1,3, Guido Alves9,10,11, Ketil Oppedal1,12,13, Hogne Soennesyn1, Audun Osland Vik-Mo1,14. 1. Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway. 2. Semillero de Neurociencias y Envejecimiento, Ageing Institute, Medical School, Pontificia Universidad Javeriana, Bogotá, Colombia. 3. Faculty of Health Sciences, University of Stavanger, Stavanger, Norway. 4. Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom. 5. School of Statistics, Faculty of Engineering, Universidad del Valle, Santiago de Cali, Colombia. 6. Department of Mathematics and Statistics, Faculty of Basic Sciences, Universidad Autónoma de Occidente, Santiago de Cali, Colombia. 7. Department of Internal Medicine, Haraldsplass Deaconess Hospital, Bergen, Norway. 8. University of Exeter Medical School, College of Medicine and Health, Exeter University, Exeter, United Kingdom. 9. The Norwegian Center for Movement Disorders, Stavanger University Hospital, Stavanger, Norway. 10. Department of Neurology, Stavanger University Hospital, Stavanger, Norway. 11. Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Stavanger, Norway. 12. Stavanger Medical Imaging Laboratory (SMIL), Stavanger University Hospital, Stavanger, Norway. 13. Department of Electrical Engineering and Computer Science, University of Stavanger, Stavanger, Norway. 14. Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Abstract
BACKGROUND/ OBJECTIVES: Functional status is one of the most important markers of well-being in older adults, but the drivers of functional decline in dementia are not well known. The aim of our work was to study the association of neuropsychiatric symptoms (NPSs) with functional decline over 5 years in newly diagnosed people with Alzheimer´s disease (AD) and Lewy body dementia (LBD). DESIGN: Secondary analysis of the Dementia Study of Western Norway longitudinal cohort study. SETTING: Multicenter study conducted in memory clinics in western Norway. PARTICIPANTS: We included a total of 196 patients newly diagnosed with AD (n = 111) and LBD (n = 85), followed up annually for 5 years. MAIN OUTCOMES AND MEASURES: The outcome was the rapid disability rating scale (items 1-13). Linear mixed-effects models were used for analysis with the total score of the Norwegian Neuropsychiatric Inventory (NPI) as a predictor measured either at baseline or longitudinally, adjusted for potential confounders, including cognition. Effect modification was checked by introducing interactions with NPI score and stratifying by diagnosis. RESULTS: The total NPI score longitudinal course was associated with functional decline in both AD and LBD. At baseline, the total NPI score predicted functional decline in AD. CONCLUSION: NPSs were associated with the rate of functional decline in people with AD and LBD, independent of cognitive impairment. These results highlight the relevance of early detection and intervention of NPSs, which may also reduce functional decline. J Am Geriatr Soc 68:2257-2263, 2020.
BACKGROUND/ OBJECTIVES: Functional status is one of the most important markers of well-being in older adults, but the drivers of functional decline in dementia are not well known. The aim of our work was to study the association of neuropsychiatric symptoms (NPSs) with functional decline over 5 years in newly diagnosed people with Alzheimer´s disease (AD) and Lewy body dementia (LBD). DESIGN: Secondary analysis of the Dementia Study of Western Norway longitudinal cohort study. SETTING: Multicenter study conducted in memory clinics in western Norway. PARTICIPANTS: We included a total of 196 patients newly diagnosed with AD (n = 111) and LBD (n = 85), followed up annually for 5 years. MAIN OUTCOMES AND MEASURES: The outcome was the rapid disability rating scale (items 1-13). Linear mixed-effects models were used for analysis with the total score of the Norwegian Neuropsychiatric Inventory (NPI) as a predictor measured either at baseline or longitudinally, adjusted for potential confounders, including cognition. Effect modification was checked by introducing interactions with NPI score and stratifying by diagnosis. RESULTS: The total NPI score longitudinal course was associated with functional decline in both AD and LBD. At baseline, the total NPI score predicted functional decline in AD. CONCLUSION: NPSs were associated with the rate of functional decline in people with AD and LBD, independent of cognitive impairment. These results highlight the relevance of early detection and intervention of NPSs, which may also reduce functional decline. J Am Geriatr Soc 68:2257-2263, 2020.
Authors: Marie H Gedde; Bettina S Husebo; Janne Mannseth; Mala Naik; Geir Selbaek; Maarja Vislapuu; Line Iden Berge Journal: BMC Med Date: 2022-05-26 Impact factor: 11.150
Authors: Karlee S Patrick; John Gunstad; John T Martin; Kimberly R Chapman; Jennifer Drost; Mary Beth Spitznagel Journal: Psychogeriatrics Date: 2022-07-19 Impact factor: 2.295