Novel algebraic meal disturbance estimation based adaptive robust control design for blood glucose regulation in type 1 diabetes patients.

This study designs a robust closed-loop control algorithm for elevated blood glucose level stabilisation in type 1 diabetic patients. The control algorithm is based on a novel control action resulting from integrating algebraic meal disturbance estimator with back-stepping integral sliding mode control (BISMC) technique. The estimator shows finite time convergence leading to accurate and fast estimation of meal disturbance. Moreover, compensation of the estimated disturbance in controller provides significant reduction in chattering phenomenon, which is inherent drawback of sliding mode control (SMC). The controller is applied to one of the most reliable models of type 1 diabetic patients, named Bergman's minimal model. The effectiveness and superiority of the designed controller is shown by comparing it to classical SMC and super-twisting sliding mode control. The designed controller is subject to three different cases for detailed analysis of the controller's robustness against meal disturbance. The three cases considered are hyperglycaemia, hyperglycaemia combined with meal disturbance and three meal disturbance. The simulation results confirm superior performance of algebraic disturbance estimator based BISMC controller for all the cases mentioned above.