Literature DB >> 32736967

Investigating Microglia in Health and Disease: Challenges and Opportunities.

Veronique E Miron1, Josef Priller2.   

Abstract

Microglia are tissue-resident macrophages implicated in central nervous system (CNS) development, homeostasis, and response to injury. Recent advances in transcriptomics, multiplex protein expression analysis, and experimental depletion of microglia have cemented their importance. However, it is still unclear which models are best suited to investigate microglia and explore their function in human disease. Here, we discuss issues regarding off-targeting during experimental manipulation, and differences and similarities between human and rodent microglia. With new developments in transgenic lines and human-rodent chimeras, we anticipate that in coming years, a clearer picture of microglia function in health and disease will emerge.
Copyright © 2020 Elsevier Ltd. All rights reserved.

Entities:  

Year:  2020        PMID： 32736967     DOI： 10.1016/j.it.2020.07.002

Source DB:  PubMed          Journal:  Trends Immunol        ISSN： 1471-4906            Impact factor:   16.687


  13 in total

Review 1.  Microglia Phenotypes in Aging and Neurodegenerative Diseases.

Authors:  Menbere Y Wendimu; Shelley B Hooks
Journal:  Cells       Date:  2022-06-30       Impact factor: 7.666

2.  Cyclosporine A loaded brain targeting nanoparticle to treat cerebral ischemia/reperfusion injury in mice.

Authors:  Daozhou Liu; Qifeng Ji; Ying Cheng; Miao Liu; Bangle Zhang; Qibing Mei; Menglei Huan; Siyuan Zhou
Journal:  J Nanobiotechnology       Date:  2022-06-03       Impact factor: 9.429

Review 3.  Glucose Metabolism, Neural Cell Senescence and Alzheimer's Disease.

Authors:  Qianqian Wang; Linyan Duan; Xingfan Li; Yifu Wang; Wenna Guo; Fangxia Guan; Shanshan Ma
Journal:  Int J Mol Sci       Date:  2022-04-14       Impact factor: 6.208

Review 4.  Microglia Biomarkers in Alzheimer's Disease.

Authors:  Peng-Fei Zhang; Hao Hu; Lan Tan; Jin-Tai Yu
Journal:  Mol Neurobiol       Date:  2021-03-12       Impact factor: 5.590

Review 5.  Hypothalamic Microglial Heterogeneity and Signature under High Fat Diet-Induced Inflammation.

Authors:  Natália Ferreira Mendes; Carlos Poblete Jara; Ariane Maria Zanesco; Eliana Pereira de Araújo
Journal:  Int J Mol Sci       Date:  2021-02-24       Impact factor: 5.923

Review 6.  White matter microglia heterogeneity in the CNS.

Authors:  Sandra Amor; Niamh B McNamara; Emma Gerrits; Manuel C Marzin; Susanne M Kooistra; Veronique E Miron; Erik Nutma
Journal:  Acta Neuropathol       Date:  2021-12-08       Impact factor: 17.088

Review 7.  Honing the Double-Edged Sword: Improving Human iPSC-Microglia Models.

Authors:  Anne Hedegaard; Szymon Stodolak; William S James; Sally A Cowley
Journal:  Front Immunol       Date:  2020-12-08       Impact factor: 7.561

8.  Transcriptome Analysis of Microglia Reveals That the TLR2/IRF7 Signaling Axis Mediates Neuroinflammation After Subarachnoid Hemorrhage.

Authors:  Shenbin Xu; Shuhao Mei; Jianan Lu; Haijian Wu; Xiao Dong; Ligen Shi; Jingyi Zhou; Jianmin Zhang
Journal:  Front Aging Neurosci       Date:  2021-06-30       Impact factor: 5.750

Review 9.  Cytomegalovirus Infection and Inflammation in Developing Brain.

Authors:  Fran Krstanović; William J Britt; Stipan Jonjić; Ilija Brizić
Journal:  Viruses       Date:  2021-06-04       Impact factor: 5.048

10.  An overlooked subset of Cx3cr1wt/wt microglia in the Cx3cr1CreER-Eyfp/wt mouse has a repopulation advantage over Cx3cr1CreER-Eyfp/wt microglia following microglial depletion.

Authors:  Kai Zhou; Jinming Han; Harald Lund; Nageswara Rao Boggavarapu; Volker M Lauschke; Shinobu Goto; Huaitao Cheng; Yuyu Wang; Asuka Tachi; Cuicui Xie; Keying Zhu; Ying Sun; Ahmed M Osman; Dong Liang; Wei Han; Kristina Gemzell-Danielsson; Christer Betsholtz; Xing-Mei Zhang; Changlian Zhu; Martin Enge; Bertrand Joseph; Robert A Harris; Klas Blomgren
Journal:  J Neuroinflammation       Date:  2022-01-21       Impact factor: 8.322
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.