Shi-Yi Wang1,2,3, Yin-Feng Wang1,2, Chun-Chen Pan4,5, Jing-Wu Sun6,7. 1. Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of University of Science and Technology of China, No. 17 Lujiang Road, Hefei, Anhui Province, 230001, People's Republic of China. 2. Department of Otolaryngology-Head and Neck Surgery, Anhui Provincial Hospital Affiliated Anhui Medical University, No. 17 Lujiang Road, Hefei, Anhui Province, 230001, People's Republic of China. 3. Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Yangzhou University, No. 368 Hanjiang Middle Road, Yangzhou, Jiangsu Province, 225001, People's Republic of China. 4. Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of University of Science and Technology of China, No. 17 Lujiang Road, Hefei, Anhui Province, 230001, People's Republic of China. panchunchen@hotmail.com. 5. Department of Otolaryngology-Head and Neck Surgery, Anhui Provincial Hospital Affiliated Anhui Medical University, No. 17 Lujiang Road, Hefei, Anhui Province, 230001, People's Republic of China. panchunchen@hotmail.com. 6. Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of University of Science and Technology of China, No. 17 Lujiang Road, Hefei, Anhui Province, 230001, People's Republic of China. entsunjw@163.com. 7. Department of Otolaryngology-Head and Neck Surgery, Anhui Provincial Hospital Affiliated Anhui Medical University, No. 17 Lujiang Road, Hefei, Anhui Province, 230001, People's Republic of China. entsunjw@163.com.
Abstract
BACKGROUND: Allergic rhinitis (AR) is one of the most prevalent allergic diseases in children. This study aimed to investigate the association between serum concentrations of vitamin E and AR to determine if the vitamin E level is correlated with the occurrence and severity of AR. METHODS: A total of 113 children were enrolled in this cross-sectional study. Sixty-five children in the outpatient group were diagnosed with AR, and 48 healthy children were recruited as controls. All subjects underwent serum vitamin E (adjusted for total cholesterol and triglycerides) measurements. Serum to total IgE (tIgE), the five most common allergen-specific IgE (sIgE) levels and skin prick test (SPT) were measured in children with AR. The severity of AR was assessed with the nasal symptoms score, and the situation of exposure to passive smoking were inquired. RESULTS: Serum vitamin E levels were significantly lower in the AR group than in the normal children (P < 0.001). A significant negative correlation was observed between serum vitamin E levels and sIgE as well as the SPT grade. Serum vitamin E levels were also inversely related to the nasal symptoms score; however, statistical significance was not found. CONCLUSIONS: A significantly lower vitamin E level was found in children with AR. Lower serum vitamin E levels may have correlation with the occurrence of AR in children. However, serum vitamin E levels were not statistically correlated with the severity of AR.
BACKGROUND:Allergic rhinitis (AR) is one of the most prevalent allergic diseases in children. This study aimed to investigate the association between serum concentrations of vitamin E and AR to determine if the vitamin E level is correlated with the occurrence and severity of AR. METHODS: A total of 113 children were enrolled in this cross-sectional study. Sixty-five children in the outpatient group were diagnosed with AR, and 48 healthy children were recruited as controls. All subjects underwent serum vitamin E (adjusted for total cholesterol and triglycerides) measurements. Serum to total IgE (tIgE), the five most common allergen-specific IgE (sIgE) levels and skin prick test (SPT) were measured in children with AR. The severity of AR was assessed with the nasal symptoms score, and the situation of exposure to passive smoking were inquired. RESULTS: Serum vitamin E levels were significantly lower in the AR group than in the normal children (P < 0.001). A significant negative correlation was observed between serum vitamin E levels and sIgE as well as the SPT grade. Serum vitamin E levels were also inversely related to the nasal symptoms score; however, statistical significance was not found. CONCLUSIONS: A significantly lower vitamin E level was found in children with AR. Lower serum vitamin E levels may have correlation with the occurrence of AR in children. However, serum vitamin E levels were not statistically correlated with the severity of AR.
Entities:
Keywords:
Allergic rhinitis; Children; Skin prick test; Specific IgE; Total IgE; Vitamin E
Authors: J Bousquet; L Heinzerling; C Bachert; N G Papadopoulos; P J Bousquet; P G Burney; G W Canonica; K H Carlsen; L Cox; T Haahtela; K C Lodrup Carlsen; D Price; B Samolinski; F E R Simons; M Wickman; I Annesi-Maesano; C E Baena-Cagnani; K C Bergmann; C Bindslev-Jensen; T B Casale; A Chiriac; A A Cruz; R Dubakiene; S R Durham; W J Fokkens; R Gerth-van-Wijk; O Kalayci; M L Kowalski; A Mari; J Mullol; L Nazamova-Baranova; R E O'Hehir; K Ohta; P Panzner; G Passalacqua; J Ring; B Rogala; A Romano; D Ryan; P Schmid-Grendelmeier; A Todo-Bom; R Valenta; S Woehrl; O M Yusuf; T Zuberbier; P Demoly Journal: Allergy Date: 2011-11-04 Impact factor: 13.146
Authors: Lorenzo Loffredo; Anna Maria Zicari; Francesca Occasi; Ludovica Perri; Roberto Carnevale; Francesco Angelico; Maria Del Ben; Francesco Martino; Cristina Nocella; Giovanna De Castro; Vittoria Cammisotto; Simona Battaglia; Marzia Duse; Francesco Violi Journal: Thorax Date: 2018-02-15 Impact factor: 9.139