Takahide Kato1, Takaaki Matsumoto2, Stanley M Yamashiro3. 1. Department of General Education, National Institute of Technology, Toyota College, Toyota, Japan - tkato@toyota-ct.ac.jp. 2. Laboratory for Exercise Physiology and Biomechanics, School of Health and Sport Sciences, Chukyo University, Toyota, Japan. 3. Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
Abstract
BACKGROUND: The aim of this study was to examine whether the decrease in respiratory exchange ratio (RER) during constant work-rate exercise (CWE) with 3% carbon dioxide (CO<inf>2</inf>) inhalation could be caused by the combination of the decrease in CO<inf>2</inf> output (V̇CO<inf>2</inf>) and the increase in oxygen uptake (V̇O<inf>2</inf>). In addition, we investigated the effect of 3% CO<inf>2</inf> inhalation on cardiac output (Q̇) during CWE. METHODS: Seven males (V̇O<inf>2max</inf>: 44.1±6.4 mL/min/kg) carried out transitions from low-load cycling (baseline; 40w) to light intensity exercise (45% V̇O<inf>2 max</inf>; 89.3±12.5 W) and heavy intensity exercise (80% V̇O<inf>2max</inf>; 186.5±20.2 W) while inhaling normal air (Air) or an enriched CO<inf>2</inf> gas (3% CO<inf>2</inf>, 21% O<inf>2</inf>, balance N<inf>2</inf>). Each exercise session was 6 min, and respiratory responses by Douglas bag technique and cardiac responses by thoracic bio-impedance method were measured during the experiment. RESULTS: Ventilation for 3% CO<inf>2</inf> was higher than for air through the experiment (P<0.05). Steady and non-steady state RER and V̇CO<inf>2</inf> for 3% CO<inf>2</inf> were less than for air in both light and heavy intensities (P<0.05), but V̇O<inf>2</inf> and Q̇ did not differ between the two conditions. CONCLUSIONS: 3% CO<inf>2</inf> inhalation induced the decrease in RER during CWE at light and heavy intensities, which was due to the decrease in V̇CO<inf>2</inf>. The promoted ventilation with 3% CO<inf>2</inf> did not lead to the increase in V̇O<inf>2</inf>. Moreover, 3% CO<inf>2</inf> inhalation did not affect Q̇ during CWE at light and heavy intensities.
BACKGROUND: The aim of this study was to examine whether the decrease in respiratory exchange ratio (RER) during constant work-rate exercise (CWE) with 3% carbon dioxide (CO<inf>2</inf>) inhalation could be caused by the combination of the decrease in CO<inf>2</inf> output (V̇CO<inf>2</inf>) and the increase in oxygen uptake (V̇O<inf>2</inf>). In addition, we investigated the effect of 3% CO<inf>2</inf> inhalation on cardiac output (Q̇) during CWE. METHODS: Seven males (V̇O<inf>2max</inf>: 44.1±6.4 mL/min/kg) carried out transitions from low-load cycling (baseline; 40w) to light intensity exercise (45% V̇O<inf>2 max</inf>; 89.3±12.5 W) and heavy intensity exercise (80% V̇O<inf>2max</inf>; 186.5±20.2 W) while inhaling normal air (Air) or an enriched CO<inf>2</inf> gas (3% CO<inf>2</inf>, 21% O<inf>2</inf>, balance N<inf>2</inf>). Each exercise session was 6 min, and respiratory responses by Douglas bag technique and cardiac responses by thoracic bio-impedance method were measured during the experiment. RESULTS: Ventilation for 3% CO<inf>2</inf> was higher than for air through the experiment (P<0.05). Steady and non-steady state RER and V̇CO<inf>2</inf> for 3% CO<inf>2</inf> were less than for air in both light and heavy intensities (P<0.05), but V̇O<inf>2</inf> and Q̇ did not differ between the two conditions. CONCLUSIONS: 3% CO<inf>2</inf> inhalation induced the decrease in RER during CWE at light and heavy intensities, which was due to the decrease in V̇CO<inf>2</inf>. The promoted ventilation with 3% CO<inf>2</inf> did not lead to the increase in V̇O<inf>2</inf>. Moreover, 3% CO<inf>2</inf> inhalation did not affect Q̇ during CWE at light and heavy intensities.