Literature DB >> 327331

Is an early calcium flux necessary to stimulate lymphocytes?

T R Hesketh, G A Smith, M D Houslay, G B Warren, J C Metcalfe.   

Abstract

Concentrations of concanavalin A or the calcium ionophore A23187 that are optimal for the transformation of pig or mouse lymphocytes do not normally cause a measurable increase in calcium influx compared with unstimulated cells. If the cells are treated with the mitogens in conditions where a measurable increase in calcium influx occurs, no stimulation of the cells can occur while the flux is maintained. If an early influx of extracellular calcium is necessary for stimulation, then a much smaller increase in the total concentration of cellular calcium than reported previously is sufficient to allow the entry of lymphocytes into the cell cycle.

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Year:  1977        PMID： 327331     DOI： 10.1038/267490a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  23 in total

1.  Kinetics of 21-trisomic lymphocytes. I. In vitro response of 21-trisomic lymphocytes to PHA.

Authors:  A Serra; E Arpaia; R Bova
Journal:  Hum Genet       Date:  1978-03-17       Impact factor: 4.132

Review 2.  Role of ion channels in lymphocytes.

Authors:  B A Premack; P Gardner
Journal:  J Clin Immunol       Date:  1991-09       Impact factor: 8.317

3.  Transglutaminase activity in human lymphocytes: early activation by phytomitogens.

Authors:  A Novogrodsky; S Quittner; A L Rubin; K H Stenzel
Journal:  Proc Natl Acad Sci U S A       Date:  1978-03       Impact factor: 11.205

Review 4.  Ion channels in lymphocytes.

Authors:  K G Chandy; T E DeCoursey; M D Cahalan; S Gupta
Journal:  J Clin Immunol       Date:  1985-01       Impact factor: 8.317

5.  Early transmembrane events in alloimmune cytotoxic T-lymphocyte activation as revealed by stopped-flow fluorometry.

Authors:  N Utsunomiya; M Tsuboi; M Nakanishi
Journal:  Proc Natl Acad Sci U S A       Date:  1986-03       Impact factor: 11.205

6.  Cell cycle regulation by growth factors and nutrients in normal and transformed cells.

Authors:  D Paul; K D Brown; H T Rupniak; H J Ristow
Journal:  In Vitro       Date:  1978-01

Review 7.  Intracellular calcium regulation and the measurement of free calcium in 2H3 cells and synaptosomes.

Authors:  R Hesketh
Journal:  Br J Clin Pharmacol       Date:  1985       Impact factor: 4.335

8.  Concanavalin A-stimulated Ca2+ uptake in rat splenocytes.

Authors:  A Larner; L I Rebhun; J Larner; Y Oron
Journal:  Mol Cell Biochem       Date:  1980-11-20       Impact factor: 3.396

9.  Limits to the early increase in free cytoplasmic calcium concentration during the mitogenic stimulation of lymphocytes.

Authors:  T R Hesketh; T Pozzan; G A Smith; J C Metcalfe
Journal:  Biochem J       Date:  1983-06-15       Impact factor: 3.857

10.  Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator.

Authors:  R Y Tsien; T Pozzan; T J Rink
Journal:  J Cell Biol       Date:  1982-08       Impact factor: 10.539
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