Abdullah Kursat Cingu1, Fatih Mehmet Turkcu2, Serdar Aktas3, Alparslan Sahin4, Orhan Ayyildiz5. 1. Department of Ophthalmology, Veni Vidi Bakirkoy Eye Center, Zeytinlik Mahallesi Milliyetci Sok. No: 4/1, Bakirkoy, Istanbul, Turkey. kursatcingu@yahoo.com. 2. Department of Ophthalmology, Diyarbakir Bower Hospital, Diyarbakir, Turkey. 3. Department of Immunology, Doruk Bursa Hospital, Bursa, Turkey. 4. Department of Ophthalmology, Memorial Dicle Hospital, Diyarbakir, Turkey. 5. Department of Internal Medicine, Dicle University School of Medicine, Diyarbakir, Turkey.
Abstract
PURPOSE: To investigate serum levels of interleukin (IL)-12 (Th1 cytokine), IL-27 (an immunomodulatory cytokine), IL-4 (suppressor of Th1-cell growth), IL-13 (a stimulatory signal for Th2 cytokines), and IL-33 (an epithelial cell-derived cytokine) and their relations with the disease activity in Behcet's Disease (BD). METHODS: Four groups, each composed of 20 participants were enrolled in the study; active ocular BD (Group-A), ocular BD in remission (Group-B), nonocular BD in remission (Group-C) and healthy controls (Group-D). IL levels were compared between the study groups and their correlation with the disease activity parameters were analyzed. RESULTS: IL-13 and IL-33 were higher in Group-A. IL-27 was lower in all BD groups. Additionally, IL-13 and IL-33 levels were positively correlated with disease activity parameters. CONCLUSION: These findings show Th2 dominance in the active phase of BD. Besides, decreased levels of IL-27, and presumably, its protective anti-inflammatory effect in all study groups may exert a new pathologic finding in BD.
PURPOSE: To investigate serum levels of interleukin (IL)-12 (Th1 cytokine), IL-27 (an immunomodulatory cytokine), IL-4 (suppressor of Th1-cell growth), IL-13 (a stimulatory signal for Th2 cytokines), and IL-33 (an epithelial cell-derived cytokine) and their relations with the disease activity in Behcet's Disease (BD). METHODS: Four groups, each composed of 20 participants were enrolled in the study; active ocular BD (Group-A), ocular BD in remission (Group-B), nonocular BD in remission (Group-C) and healthy controls (Group-D). IL levels were compared between the study groups and their correlation with the disease activity parameters were analyzed. RESULTS:IL-13 and IL-33 were higher in Group-A. IL-27 was lower in all BD groups. Additionally, IL-13 and IL-33 levels were positively correlated with disease activity parameters. CONCLUSION: These findings show Th2 dominance in the active phase of BD. Besides, decreased levels of IL-27, and presumably, its protective anti-inflammatory effect in all study groups may exert a new pathologic finding in BD.