Alan D Kaye1, George M Jeha2, Vanessa Moll3, Ceressa T Ward4, Matthew R Watson4, John Thomas Wynn5, Maxwell A Hockstein6, Kevin M Hall7, Omar Viswanath8,9,10, Ivan Urits11, Amit Prabhakar12, Elyse M Cornett13. 1. Department of Anesthesiology, LSU Health Shreveport, Shreveport, LA, USA. 2. Department of Anesthesiology, LSU Health New Orleans, New Orleans, LA, USA. 3. Institute of Anesthesiology, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, Switzerland. 4. Department of Pharmacy, Emory University Hospital Midtown, Atlanta, GA, USA. 5. Emory Critical Care Center, Emory University Hospital Midtown, Atlanta, GA, USA. 6. Department of Anesthesia, Emory University School of Medicine, Atlanta, GA, USA. 7. Department of Anesthesiology, Emory University Hospital Midtown, Atlanta, GA, USA. 8. Valley Anesthesiology and Pain Consultants-Envision Physician Services, Phoenix, AZ, USA. 9. Department of Anesthesiology, University of Arizona College of Medicine-Phoenix, Phoenix, AZ, USA. 10. Department of Anesthesiology, Creighton University School of Medicine, Omaha, NE, USA. 11. Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. 12. Division of Critical Care, Department of Anesthesiology, Emory School of Medicine, Atlanta, GA, USA. 13. Department of Anesthesiology, LSU Health Shreveport, Shreveport, LA, USA. ecorne@lsuhsc.edu.
Abstract
INTRODUCTION: Platelet diseases and dysfunction are taught early in medical school to all future physicians. Understanding of the coagulation cascade and hemostatic mechanisms has allowed for targeted pharmacological therapies that have been significantly impactful in clinical practice. Platelets are an early participant in hemostasis physiologically and under pathophysiological states. METHODS: A review of literature involving platelet disfunction. RESULTS: Various presentations of platelet diseases and dysfunction challenge clinicians and require a firm understanding of normal platelet function, drugs that mediate or modulate platelet effectiveness, and nonpharmacologic etiologies of platelet diseases and dysfunction with corresponding best practice treatment approaches. CONCLUSION: This review summarizes normal and abnormal states associated with platelets and treatment strategies.
INTRODUCTION:Platelet diseases and dysfunction are taught early in medical school to all future physicians. Understanding of the coagulation cascade and hemostatic mechanisms has allowed for targeted pharmacological therapies that have been significantly impactful in clinical practice. Platelets are an early participant in hemostasis physiologically and under pathophysiological states. METHODS: A review of literature involving platelet disfunction. RESULTS: Various presentations of platelet diseases and dysfunction challenge clinicians and require a firm understanding of normal platelet function, drugs that mediate or modulate platelet effectiveness, and nonpharmacologic etiologies of platelet diseases and dysfunction with corresponding best practice treatment approaches. CONCLUSION: This review summarizes normal and abnormal states associated with platelets and treatment strategies.
Authors: Linsey J F Peters; Constance C F M J Baaten; Sanne L Maas; Chang Lu; Magdolna Nagy; Natalie J Jooss; Kiril Bidzhekov; Donato Santovito; Daniel Moreno-Andrés; Joachim Jankowski; Erik A L Biessen; Yvonne Döring; Johan W M Heemskerk; Christian Weber; Marijke J E Kuijpers; Emiel P C van der Vorst Journal: Biomedicines Date: 2022-04-23