Kenshiro Takemoto1,2,3, Jun Teishima4, Yuki Kohada2, Kenichiro Ikeda4, Hirotaka Nagamatsu3, Akihiro Goriki2, Shogo Inoue4, Tetsutaro Hayashi4, Mitsuru Kajiwara2, Akio Matsubara4. 1. Department of Urology, Graduate School of Biomedical and Health Science, Hiroshima University, Hiroshima, Japan kenshiro_takemoto@yahoo.co.jp. 2. Department of Urology, Hiroshima Prefectural Hospital, Hiroshima, Japan. 3. Department of Urology, Nakatsu Daiichi Hospital, Oita, Japan. 4. Department of Urology, Graduate School of Biomedical and Health Science, Hiroshima University, Hiroshima, Japan.
Abstract
BACKGROUND/AIM: Bladder cancer with histological variant (HV) has different morphological features from usual urothelial carcinoma (UC). The aim of this study was to evaluate the oncological outcomes of HV in patients with bladder cancer. PATIENTS AND METHODS: We retrospectively evaluated data from 102 patients with UC of the bladder treated with radical cystectomy between 1998 and 2017. Pathological findings including HV were assigned by one dedicated pathologist. Recurrence-free survival (RFS) and cancer-specific survival (CSS) and overall survival (OS) were estimated by Cox regression models. RESULTS: In total, 26 patients (25.5%) had HV, and the most common variant was squamous differentiation, followed by glandular differentiation and a mixed variant consisted of squamous and glandular differentiation. The presence of HV was associated with RFS and CSS (p=0.018, p=0.036, respectively). CONCLUSION: HV has more aggressive tumor biological features compared to those with pure UC. The presence of HV was associated with poor survival. Copyright
BACKGROUND/AIM: Bladder cancer with histological variant (HV) has different morphological features from usual urothelial carcinoma (UC). The aim of this study was to evaluate the oncological outcomes of HV in patients with bladder cancer. PATIENTS AND METHODS: We retrospectively evaluated data from 102 patients with UC of the bladder treated with radical cystectomy between 1998 and 2017. Pathological findings including HV were assigned by one dedicated pathologist. Recurrence-free survival (RFS) and cancer-specific survival (CSS) and overall survival (OS) were estimated by Cox regression models. RESULTS: In total, 26 patients (25.5%) had HV, and the most common variant was squamous differentiation, followed by glandular differentiation and a mixed variant consisted of squamous and glandular differentiation. The presence of HV was associated with RFS and CSS (p=0.018, p=0.036, respectively). CONCLUSION: HV has more aggressive tumor biological features compared to those with pure UC. The presence of HV was associated with poor survival. Copyright
Authors: Jean H Hoffman-Censits; Kara A Lombardo; Vamsi Parimi; Sonia Kamanda; Woonyoung Choi; Noah M Hahn; David J McConkey; Bridget M McGuire; Trinity J Bivalacqua; Max Kates; Andres Matoso Journal: Appl Immunohistochem Mol Morphol Date: 2021-09-01