BACKGROUND/AIM: We investigated the anti-proliferative effect of quercetin on liver cancer cell lines. MATERIALS AND METHODS: Thirteen liver cancer cell lines were cultured followed by treatment with varying concentrations of quercetin (0-100 μM) or quercetin and 5-FU, and the cell viability was analysed by the MTT assay. Flow cytometry was also used to examine cell cycle progression after treatment with quercetin. RESULTS: The addition of quercetin resulted in a dose- and time-dependent suppression of cell proliferation. In some cell lines, treatment with quercetin and 5-FU caused an additional or synergistic effect. Most cell lines displayed cell cycle arrest at different phases of the cell cycle. CONCLUSION: Quercetin inhibits the proliferation of liver cancer cells via induction of apoptosis and cell cycle arrest. Copyright
BACKGROUND/AIM: We investigated the anti-proliferative effect of quercetin on liver cancer cell lines. MATERIALS AND METHODS: Thirteen liver cancer cell lines were cultured followed by treatment with varying concentrations of quercetin (0-100 μM) or quercetin and 5-FU, and the cell viability was analysed by the MTT assay. Flow cytometry was also used to examine cell cycle progression after treatment with quercetin. RESULTS: The addition of quercetin resulted in a dose- and time-dependent suppression of cell proliferation. In some cell lines, treatment with quercetin and 5-FU caused an additional or synergistic effect. Most cell lines displayed cell cycle arrest at different phases of the cell cycle. CONCLUSION:Quercetin inhibits the proliferation of liver cancer cells via induction of apoptosis and cell cycle arrest. Copyright
Authors: Seyed Mohammad Ali Mirazimi; Fatemeh Dashti; Mohammad Tobeiha; Ali Shahini; Raha Jafari; Mehrad Khoddami; Amir Hossein Sheida; Parastoo EsnaAshari; Amir Hossein Aflatoonian; Fateme Elikaii; Melika Sadat Zakeri; Michael R Hamblin; Mohammad Aghajani; Minoodokht Bavarsadkarimi; Hamed Mirzaei Journal: Front Pharmacol Date: 2022-04-06 Impact factor: 5.988