Tae Hun Kim1, Sang-Chul Kwon2, Jeong Nam Kim3, Ji-Hye Yoon1, Sung-Gook Cho4. 1. Major in Biotechnology, Division of Food Science and Biotechnology, College of Health and Life Science, Korea National University of Transportation, Chungbuk, Republic of Korea. 2. Major in Food Technology, Division of Food Science and Biotechnology, College of Health and Life Science, Korea National University of Transportation, Chungbuk, Republic of Korea. 3. Department of Microbiology, College of Natural Sciences, Pusan National University, Pusan, Republic of Korea. 4. Major in Biotechnology, Division of Food Science and Biotechnology, College of Health and Life Science, Korea National University of Transportation, Chungbuk, Republic of Korea chosg@ut.ac.kr.
Abstract
BACKGROUND/AIM: Although ginseng seed oil (GSO) appears to have various roles in the body, its anti-cancer effect has not been investigated. Tamoxifen is widely used to treat estrogen receptor-positive (ER+) breast cancer but shows adverse effects with drug resistance. This study investigated the effect of GSO in ER+ breast cancer cell growth. MATERIALS AND METHODS: Cell viability assays, western blots and Annexin V staining were conducted to examine cell viability and apoptosis. The synergistic effect of tamoxifen in combination with GSO or oleic acid (OA) was determined. RESULTS: GSO and OA caused apoptosis of MCF-7 ER+ breast cancer cells and had synergistic effects with tamoxifen in inhibiting tamoxifen-resistant MCF-7 (MCF-7TAMR) ER+ breast cancer cell growth. CONCLUSION: GSO may block ER+ breast cancer recurrence in combination with tamoxifen. Copyright
BACKGROUND/AIM: Although ginseng seed oil (GSO) appears to have various roles in the body, its anti-cancer effect has not been investigated. Tamoxifen is widely used to treat estrogen receptor-positive (ER+) breast cancer but shows adverse effects with drug resistance. This study investigated the effect of GSO in ER+ breast cancer cell growth. MATERIALS AND METHODS: Cell viability assays, western blots and Annexin V staining were conducted to examine cell viability and apoptosis. The synergistic effect of tamoxifen in combination with GSO or oleic acid (OA) was determined. RESULTS:GSO and OA caused apoptosis of MCF-7 ER+ breast cancer cells and had synergistic effects with tamoxifen in inhibiting tamoxifen-resistant MCF-7 (MCF-7TAMR) ER+ breast cancer cell growth. CONCLUSION:GSO may block ER+ breast cancer recurrence in combination with tamoxifen. Copyright