Chao-Chun Chen1, Pei-Chen Hsu1, Liang-Chun Shih2,3, Yuan-Nian Hsu4, Chien-Chung Kuo5, Che-Yi Chao6, Wen-Shin Chang2,7, Chia-Wen Tsai2,7, DA-Tian Bau8,7,9, Jen-Sheng Pei10. 1. Department of Pediatrics, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan, R.O.C. 2. Department of Medical Research, Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C. 3. Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan, R.O.C. 4. Department of Family Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan, R.O.C. 5. Department of Pediatric Orthopedics, China Medical University Hospital, Taichung, Taiwan, R.O.C. 6. Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, R.O.C. 7. Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C. 8. Department of Medical Research, Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C. datian@mail.cmuh.org.tw artbau2@gmail.com. 9. Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan, R.O.C. 10. Department of Pediatrics, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan, R.O.C. datian@mail.cmuh.org.tw artbau2@gmail.com.
Abstract
BACKGROUND/AIM: The roles of microRNAs (miRNAs) in tumorigenesis have attracted a lot of attention. The current study aimed at examining the association of the miR-196a-2 rs11614913 genotypes with susceptibility to childhood acute lymphoblastic leukemia (ALL) in Taiwan. MATERIALS AND METHODS: This case-control investigation recruited 266 patients with childhood ALL and 266 healthy controls, and the miR-196a-2 rs11614913 genotypes of each participant were examined via the polymerase chain reaction-restriction fragment length polymorphism methodology. RESULTS: The frequency of miR-196a-2 C allele in controls was 0.440 compared with 0.423 in ALL patients. In addition, there was no significant association between CT or CC genotypes with susceptibility to childhood ALL (OR=0.89 and 0.89, 95%CI=0.60-1.30 and 0.54-1.45, p=0.5427 and 0.6302). Furthermore, the frequencies of miR-196a-2 polymorphisms were not associated with age, gender and clinical outcomes in ALL cases. CONCLUSION: The miR-19a-2 genotypes are not associated with susceptibility to childhood ALL in Taiwan. Copyright
BACKGROUND/AIM: The roles of microRNAs (miRNAs) in tumorigenesis have attracted a lot of attention. The current study aimed at examining the association of the miR-196a-2rs11614913 genotypes with susceptibility to childhood acute lymphoblastic leukemia (ALL) in Taiwan. MATERIALS AND METHODS: This case-control investigation recruited 266 patients with childhood ALL and 266 healthy controls, and the miR-196a-2rs11614913 genotypes of each participant were examined via the polymerase chain reaction-restriction fragment length polymorphism methodology. RESULTS: The frequency of miR-196a-2 C allele in controls was 0.440 compared with 0.423 in ALL patients. In addition, there was no significant association between CT or CC genotypes with susceptibility to childhood ALL (OR=0.89 and 0.89, 95%CI=0.60-1.30 and 0.54-1.45, p=0.5427 and 0.6302). Furthermore, the frequencies of miR-196a-2 polymorphisms were not associated with age, gender and clinical outcomes in ALL cases. CONCLUSION: The miR-19a-2 genotypes are not associated with susceptibility to childhood ALL in Taiwan. Copyright
Authors: Silvia Jiménez-Morales; Juan Carlos Núñez-Enríquez; Jazmín Cruz-Islas; Vilma Carolina Bekker-Méndez; Elva Jiménez-Hernández; Aurora Medina-Sanson; Irma Olarte-Carrillo; Adolfo Martínez-Tovar; Janet Flores-Lujano; Julian Ramírez-Bello; María Luisa Pérez-Saldívar; Jorge Alfonso Martín-Trejo; Héctor Pérez-Lorenzana; Raquel Amador-Sánchez; Felix Gustavo Mora-Ríos; José Gabriel Peñaloza-González; David Aldebarán Duarte-Rodríguez; José Refugio Torres-Nava; Juan Eduardo Flores-Bautista; Rosa Martha Espinosa-Elizondo; Pedro Francisco Román-Zepeda; Luz Victoria Flores-Villegas; Edna Liliana Tamez-Gómez; Víctor Hugo López-García; José Ramón Lara-Ramos; Juana Esther González-Ulivarri; Sofía Irene Martínez-Silva; Gilberto Espinoza-Anrubio; Carolina Almeida-Hernández; Rosario Ramírez-Colorado; Luis Hernández-Mora; Luis Ramiro García-López; Gabriela Adriana Cruz-Ojeda; Arturo Emilio Godoy-Esquivel; Iris Contreras-Hernández; Abraham Medina-Hernández; María Guadalupe López-Caballero; Norma Angélica Hernández-Pineda; Jorge Granados-Kraulles; María Adriana Rodríguez-Vázquez; Delfino Torres-Valle; Carlos Cortés-Reyes; Francisco Medrano-López; Jessica Arleet Pérez-Gómez; Annel Martínez-Ríos; Antonio Aguilar-De-Los-Santos; Berenice Serafin-Díaz; María de Lourdes Gutiérrez-Rivera; Laura Elizabeth Merino-Pasaye; Gilberto Vargas-Alarcón; Minerva Mata-Rocha; Omar Alejandro Sepúlveda-Robles; Haydeé Rosas-Vargas; Alfredo Hidalgo-Miranda; Juan Manuel Mejía-Aranguré Journal: Front Oncol Date: 2021-11-05 Impact factor: 6.244