Yumiko Ishizuka1, Yoshiya Horimoto2,3, Mei Nakamura1,4, Atsushi Arakawa3, Tomoyuki Fujita5, Kotaro Iijima1, Mitsue Saito1. 1. Department of Breast Oncology, Juntendo University School of Medicine, Tokyo, Japan. 2. Department of Breast Oncology, Juntendo University School of Medicine, Tokyo, Japan horimoto@juntendo.ac.jp. 3. Department of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan. 4. Department of Surgery, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan. 5. Department of Breast Oncology, Juntendo University Urayasu Hospital, Urayasu, Japan.
Abstract
BACKGROUND: Axillary dissection is routinely conducted for all patients with sentinel node (SN)-positive breast cancer. Metastasis to non SNs is not often found after axillary dissection in patients with SN-positive breast cancer. Thus, we investigated clinicopathological features, including immune cells in peripheral blood, in order to identify factors related to metastasis to non-SNs. PATIENTS AND METHODS: We retrospectively investigated 184 patients with SN-positive disease, treated at our institution during the 2013 through 2018 period. All clinicopathological data were obtained before and during surgery. RESULTS: Metastasis to non SNs was observed in 64 cases (35%). The platelet-to-lymphocyte ratio (PLR) and the number of SN metastases were independent of metastasis to non SNs (p=0.023 and p=0.017, respectively). Patients with metastasis to non SNs had significantly lower PLR and more SN metastases. High lymphocyte number and low platelet number resulted in a low PLR. CONCLUSION: PLR might be a marker of metastasis to non SNs. Copyright
BACKGROUND: Axillary dissection is routinely conducted for all patients with sentinel node (SN)-positive breast cancer. Metastasis to non SNs is not often found after axillary dissection in patients with SN-positive breast cancer. Thus, we investigated clinicopathological features, including immune cells in peripheral blood, in order to identify factors related to metastasis to non-SNs. PATIENTS AND METHODS: We retrospectively investigated 184 patients with SN-positive disease, treated at our institution during the 2013 through 2018 period. All clinicopathological data were obtained before and during surgery. RESULTS: Metastasis to non SNs was observed in 64 cases (35%). The platelet-to-lymphocyte ratio (PLR) and the number of SN metastases were independent of metastasis to non SNs (p=0.023 and p=0.017, respectively). Patients with metastasis to non SNs had significantly lower PLR and more SN metastases. High lymphocyte number and low platelet number resulted in a low PLR. CONCLUSION: PLR might be a marker of metastasis to non SNs. Copyright
Authors: Li Yang; Hongbiao Wang; Jinping Ma; Jinyan Hao; Chunxia Zhang; Qiang Ma; Bin Wang Journal: Am J Transl Res Date: 2021-03-15 Impact factor: 4.060