| Literature DB >> 32727337 |
Ciro Gargiulo Isacco1, Andrea Ballini2, Danila De Vito3, Kieu Cao Diem Nguyen4, Stefania Cantore1, Lucrezia Bottalico5, Lucio Quagliuolo2, Mariarosaria Boccellino2, Marina Di Domenico2, Luigi Santacroce6, Roberto Arrigoni7, Gianna Dipalma1, Francesco Inchingolo1.
Abstract
The current treatment and prevention procedures of oral disorders follow a very targeted approach considering mouth and its structures as a system that is completely independent, than the rest of the body. The main therapeutic approach is to keep the levels of oral bacteria and hygiene in an acceptable range compatible with oral-mouth health, completely separated from systemic microbial homeostasis (eubiosis vs dysbiosis). This can negatively impact the diagnosis of a more complex systemic disease and its progression. Dysbiosis occurs as a consequence of imbalance in oral and gut microbiota which leads to cardiovascular diseases, diabetes mellitus, rheumatoid arthritis, and Alzheimer's disease, as reported in current literature. Likewise, there is a need to highlight and develop a novel philosophical approach in the treatments for oral diseases that will necessarily involve nonconventional approaches. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Entities:
Keywords: Periodontal disease; central nervous system (CNS) diseases; gut dysbiosis; macrophages; oral dysbiosis; probiotics
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Year: 2021 PMID: 32727337 DOI: 10.2174/1871530320666200729142504
Source DB: PubMed Journal: Endocr Metab Immune Disord Drug Targets ISSN: 1871-5303 Impact factor: 2.895