Sodium-Glucose Cotransporter Inhibitors for the Treatment of Type 1 Diabetes Mellitus.

Sodium-glucose cotransporter inhibitors are a new class of oral antihyperglycemic drugs that have been approved for the treatment of patients with type 2 diabetes mellitus. Sodium-glucose cotransporter inhibitors reduce glucose reabsorption in the kidneys, which lowers blood glucose. In addition, they offer significant cardiovascular benefits and renal protection. Multiple phase III trials of sodium-glucose cotransporter inhibitors in patients with type 1 diabetes have been completed. The European Medicines Agency approved dapagliflozin as an adjuvant therapy to insulin for patients with type 1 diabetes who have poor blood glucose control with the optimal dose of insulin alone (body mass index ≥ 27 kg/m2). As adjuvants to insulin for patients with type 1 diabetes, sodium-glucose cotransporter inhibitors improve blood glucose control and reduce total daily insulin dose and body weight. However, there is also concern about diabetic ketoacidosis caused by sodium-glucose cotransporter inhibitors. In this review, the mechanisms of hypoglycemic action, pharmacokinetics, clinical efficacy, and safety of sodium-glucose cotransporter inhibitors for the treatment of type 1 diabetes are discussed.