Literature DB >> 32724086

Structural insights into the activation of GLP-1R by a small molecule agonist.

Honglei Ma1, Wei Huang2, Xiaoxi Wang1, Lihua Zhao1, Yi Jiang1, Feng Liu3, Wei Guo2, Xianqiang Sun2, Wenge Zhong2, Daopeng Yuan4, H Eric Xu5.   

Abstract

Entities:  

Year:  2020        PMID： 32724086      PMCID： PMC7784854          DOI： 10.1038/s41422-020-0384-8

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


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  1 in total

1.  A small molecule ligand of the glucagon-like peptide 1 receptor targets its amino-terminal hormone binding domain.

Authors:  E C Tibaduiza; C Chen; M Beinborn
Journal:  J Biol Chem       Date:  2001-08-09       Impact factor: 5.157
  1 in total
  5 in total

1.  Structural basis of peptidomimetic agonism revealed by small- molecule GLP-1R agonists Boc5 and WB4-24.

Authors:  Zhaotong Cong; Qingtong Zhou; Yang Li; Li-Nan Chen; Zi-Chen Zhang; Anyi Liang; Qing Liu; Xiaoyan Wu; Antao Dai; Tian Xia; Wei Wu; Yan Zhang; Dehua Yang; Ming-Wei Wang
Journal:  Proc Natl Acad Sci U S A       Date:  2022-05-13       Impact factor: 12.779

Review 2.  Non-peptide agonists and positive allosteric modulators of glucagon-like peptide-1 receptors: Alternative approaches for treatment of Type 2 diabetes.

Authors:  Faisal Malik; Zhijun Li
Journal:  Br J Pharmacol       Date:  2021-04-19       Impact factor: 8.739

3.  Ligand-Dependent Effects of Methionine-8 Oxidation in Parathyroid Hormone Peptide Analogues.

Authors:  Eileen J Daley; Ashok Khatri; Thomas Dean; Jean-Pierre Vilardaga; Saheem A Zaidi; Vsevolod Katritch; Thomas J Gardella
Journal:  Endocrinology       Date:  2021-02-01       Impact factor: 4.736

4.  Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor.

Authors:  Zhaotong Cong; Li-Nan Chen; Honglei Ma; Qingtong Zhou; Xinyu Zou; Chenyu Ye; Antao Dai; Qing Liu; Wei Huang; Xianqiang Sun; Xi Wang; Peiyu Xu; Lihua Zhao; Tian Xia; Wenge Zhong; Dehua Yang; H Eric Xu; Yan Zhang; Ming-Wei Wang
Journal:  Nat Commun       Date:  2021-06-18       Impact factor: 14.919

5.  Discovery of Novel Allosteric Modulators Targeting an Extra-Helical Binding Site of GLP-1R Using Structure- and Ligand-Based Virtual Screening.

Authors:  Qingtong Zhou; Wanjing Guo; Antao Dai; Xiaoqing Cai; Márton Vass; Chris de Graaf; Wenqing Shui; Suwen Zhao; Dehua Yang; Ming-Wei Wang
Journal:  Biomolecules       Date:  2021-06-23
  5 in total

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