| Literature DB >> 32723661 |
E V Naidenova1, K S Zakharov1, M Y Kartashov2, D A Agafonov1, A M Senichkina1, N'Faly Magassouba3, I Nourdine3, A A Nassour4, M B Bah4, A Kourouma4, S Boumbali4, M Y Boiro4, S A Scherbakova1, V V Kutyrev1, V G Dedkov5.
Abstract
This article presents the results of a comprehensive survey of Guinea with the aim of assessing the burden of Crimean-Congo hemorrhagic fever virus (CCHFV) in rural areas of the country. Human serum samples (n = 2207) were studied using enzyme-linked immunosorbent assay (ELISA) for the presence of specific IgG against CCHFV. In addition, 4273 samples of partially- or fully-engorged ticks from several sources (cattle, domestic and roving dogs, and small mammals) were collected and studied using ELISA and RT-qPCR to detect CCHFV antigen and specific RNA. The data obtained show that 3.0 % of the population in rural Guinea was seropositive, without significant geographical or sexual differences. Seropositive individuals, however, were mainly in the 'active age' group (16-45 years old). Among ticks studied, the estimated prevalence of CCHFV was 1.3 ± 0.4 %. Five out of eight tick species studied were identified as CCHFV carriers in Guinea. Therefore, it can be assumed that the territory of Guinea is a single, continuous, natural focus of CCHFV. This identified medium intensity focus merits further study.Entities:
Keywords: Crimean-Congo hemorrhagic fever; Guinea; Serosurvey; Ticks; Zoonoses
Mesh：
Year: 2020 PMID： 32723661 DOI： 10.1016/j.ttbdis.2020.101475
Source DB: PubMed Journal: Ticks Tick Borne Dis ISSN： 1877-959X Impact factor: 3.744