Liubov Kozlovskaya1, Anastasia Piniaeva2, Georgy Ignatyev2, Alexey Selivanov2, Anna Shishova3, Anastasia Kovpak2, Ilya Gordeychuk3, Yury Ivin2, Anastasia Berestovskaya4, Egor Prokhortchouk5, Denis Protsenko4, Mikhail Rychev5, Aydar Ishmukhametov3. 1. FSBSI "Chumakov Federal Scientific Center for Research and Development of Immune and Biological Products of the Russian Academy of Sciences" (FSBSI "Chumakov FSC R&D IBP RAS"), Moscow 108819, Russia; Sechenov Moscow State Medical University, Moscow 119991, Russia. Electronic address: lubov_i_k@mail.ru. 2. FSBSI "Chumakov Federal Scientific Center for Research and Development of Immune and Biological Products of the Russian Academy of Sciences" (FSBSI "Chumakov FSC R&D IBP RAS"), Moscow 108819, Russia. 3. FSBSI "Chumakov Federal Scientific Center for Research and Development of Immune and Biological Products of the Russian Academy of Sciences" (FSBSI "Chumakov FSC R&D IBP RAS"), Moscow 108819, Russia; Sechenov Moscow State Medical University, Moscow 119991, Russia. 4. GKB No. 40 DZM, Moscow 129301, Russia. 5. NRC "Kurchatov Institute", Moscow 123182, Russia.
Abstract
OBJECTIVES: The outbreak of coronavirus disease 2019 (COVID-19) started in December 2019 in China and then spread worldwide over the following months, involving 188 countries. The objective of this study was to determine the molecular epidemiology of the COVID-19 outbreak in Russia. METHODS: In this study, two severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains were isolated and genetically characterized. A phylogenetic analysis of all available Russian sequences was then performed and these were compared to the epidemiological data on COVID-19 incidence to evaluate the molecular epidemiology and pattern of virus spread in the territory of Russia. RESULTS AND CONCLUSIONS: Whole genome analysis of the isolates obtained in this study and 216 others isolated in Russia revealed a set of seven common mutations when compared to the original Wuhan virus, including amino acid substitutions in spike protein S and nucleoprotein N, possibly affecting their properties. Phylogenetic analysis of all Russian sequences and 8717 sequences from other countries showed multiple importations of the virus into Russia, local circulation, and several patterns of virus spread.
OBJECTIVES: The outbreak of coronavirus disease 2019 (COVID-19) started in December 2019 in China and then spread worldwide over the following months, involving 188 countries. The objective of this study was to determine the molecular epidemiology of the COVID-19 outbreak in Russia. METHODS: In this study, two severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains were isolated and genetically characterized. A phylogenetic analysis of all available Russian sequences was then performed and these were compared to the epidemiological data on COVID-19 incidence to evaluate the molecular epidemiology and pattern of virus spread in the territory of Russia. RESULTS AND CONCLUSIONS: Whole genome analysis of the isolates obtained in this study and 216 others isolated in Russia revealed a set of seven common mutations when compared to the original Wuhan virus, including amino acid substitutions in spike protein S and nucleoprotein N, possibly affecting their properties. Phylogenetic analysis of all Russian sequences and 8717 sequences from other countries showed multiple importations of the virus into Russia, local circulation, and several patterns of virus spread.
Authors: Galya V Klink; Ksenia R Safina; Elena Nabieva; Nikita Shvyrev; Sofya Garushyants; Evgeniia Alekseeva; Andrey B Komissarov; Daria M Danilenko; Andrei A Pochtovyi; Elizaveta V Divisenko; Lyudmila A Vasilchenko; Elena V Shidlovskaya; Nadezhda A Kuznetsova; Anna S Speranskaya; Andrei E Samoilov; Alexey D Neverov; Anfisa V Popova; Gennady G Fedonin; Vasiliy G Akimkin; Dmitry Lioznov; Vladimir A Gushchin; Vladimir Shchur; Georgii A Bazykin Journal: Virus Evol Date: 2022-03-05
Authors: Anastasia A Kovpak; Anastasia N Piniaeva; Oleg A Gerasimov; Irina O Tcelykh; Mayya Y Ermakova; Anna N Zyrina; Dmitry V Danilov; Yury Y Ivin; Liubov I Kozlovskaya; Aydar A Ishmukhametov Journal: Vaccines (Basel) Date: 2022-06-15
Authors: Dmitry V Bagrov; Grigory S Glukhov; Andrey V Moiseenko; Maria G Karlova; Daniil S Litvinov; Petr А Zaitsev; Liubov I Kozlovskaya; Anna A Shishova; Anastasia A Kovpak; Yury Y Ivin; Anastasia N Piniaeva; Alexey S Oksanich; Viktor P Volok; Dmitry I Osolodkin; Aydar A Ishmukhametov; Alexey M Egorov; Konstantin V Shaitan; Mikhail P Kirpichnikov; Olga S Sokolova Journal: Microsc Res Tech Date: 2021-09-09 Impact factor: 2.893
Authors: Galya V Klink; Ksenia Safina; Elena Nabieva; Nikita Shvyrev; Sofya Garushyants; Evgeniia Alekseeva; Andrey B Komissarov; Daria M Danilenko; Andrei A Pochtovyi; Elizaveta V Divisenko; Lyudmila A Vasilchenko; Elena V Shidlovskaya; Nadezhda A Kuznetsova; Andrei E Samoilov; Alexey D Neverov; Anfisa V Popova; Gennady G Fedonin; Vasiliy G Akimkin; Dmitry Lioznov; Vladimir A Gushchin; Vladimir Shchur; Georgii A Bazykin Journal: medRxiv Date: 2021-12-05
Authors: Deshan Perera; Ben Perks; Michael Potemkin; Andy Liu; Paul M K Gordon; M John Gill; Quan Long; Guido van Marle Journal: PLoS One Date: 2021-12-15 Impact factor: 3.240
Authors: Ryan P McNamara; Carolina Caro-Vegas; Justin T Landis; Razia Moorad; Linda J Pluta; Anthony B Eason; Cecilia Thompson; Aubrey Bailey; Femi Cleola S Villamor; Philip T Lange; Jason P Wong; Tischan Seltzer; Jedediah Seltzer; Yijun Zhou; Wolfgang Vahrson; Angelica Juarez; James O Meyo; Tiphaine Calabre; Grant Broussard; Ricardo Rivera-Soto; Danielle L Chappell; Ralph S Baric; Blossom Damania; Melissa B Miller; Dirk P Dittmer Journal: Cell Rep Date: 2020-10-20 Impact factor: 9.423