Literature DB >> 32721438

Loss-of-Function Mutation in PTPN2 Causes Aberrant Activation of JAK Signaling Via STAT and Very Early Onset Intestinal Inflammation.

Marianna Parlato1, Qing Nian2, Fabienne Charbit-Henrion3, Frank M Ruemmele3, Fernando Rodrigues-Lima4, Nadine Cerf-Bensussan5.   

Abstract

Entities:  

Keywords:  Autoimmunity; Immune Regulation; PTPN2; VEO-IBD

Mesh：

Substances：

Year:  2020        PMID： 32721438     DOI： 10.1053/j.gastro.2020.07.040

Source DB:  PubMed          Journal:  Gastroenterology        ISSN： 0016-5085            Impact factor:   22.682


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  7 in total

Review 1.  Monogenic inflammatory bowel disease-genetic variants, functional mechanisms and personalised medicine in clinical practice.

Authors:  Aline Azabdaftari; Kelsey D J Jones; Jochen Kammermeier; Holm H Uhlig
Journal:  Hum Genet       Date:  2022-06-28       Impact factor: 4.132

2.  Effect of type 2 diabetes mellitus on mandibular bone regeneration and the expression of T helper cell 17/regulat-ory T cell-related factors in mice.

Authors:  Ya Nan Wang; Xuan Wu; Ting Ting Jia; Yao Feng; Shi Yue Liu; Xin Xu; Dong Jiao Zhang
Journal:  Hua Xi Kou Qiang Yi Xue Za Zhi       Date:  2021-12-01

3.  Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy.

Authors:  Qing Nian; Jérémy Berthelet; Marianna Parlato; Ariel E Mechaly; Rongxing Liu; Jean-Marie Dupret; Nadine Cerf-Bensussan; Ahmed Haouz; Fernando Rodrigues Lima
Journal:  Protein Sci       Date:  2021-11-27       Impact factor: 6.725

4.  PTPN2 mutations cause epithelium-intrinsic barrier loss that synergizes with mucosal immune hyperactivation.

Authors:  Yan Y Sweat; Jerrold R Turner
Journal:  J Clin Invest       Date:  2021-09-01       Impact factor: 19.456

5.  Bowel Histology of CVID Patients Reveals Distinct Patterns of Mucosal Inflammation.

Authors:  Cornelia M van Schewick; David M Lowe; Siobhan O Burns; Sarita Workman; Andrew Symes; David Guzman; Fernando Moreira; Jennifer Watkins; Ian Clark; Bodo Grimbacher
Journal:  J Clin Immunol       Date:  2021-10-01       Impact factor: 8.542

Review 6.  T Cell Protein Tyrosine Phosphatase in Glucose Metabolism.

Authors:  Ya-Nan Wang; Shiyue Liu; Tingting Jia; Yao Feng; Xin Xu; Dongjiao Zhang
Journal:  Front Cell Dev Biol       Date:  2021-06-29

Review 7.  T Cell Protein Tyrosine Phosphatase in Osteoimmunology.

Authors:  Ya-Nan Wang; Shiyue Liu; Tingting Jia; Yao Feng; Wenjing Zhang; Xin Xu; Dongjiao Zhang
Journal:  Front Immunol       Date:  2021-02-22       Impact factor: 7.561
  7 in total

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