Jie Gu1, Qing-Qing Su1, Ting-Ting Zuo1, Yan-Bin Chen2. 1. Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, 899# Pinghai Road, Suzhou, 215000, China. 2. Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, 899# Pinghai Road, Suzhou, 215000, China. chen001chen@163.com.
Abstract
OBJECTIVE: The clinical characteristics of various adenovirus (ADV) infection are underexplored up till now. To investigate the risk factors, manifestation, current status of ADV species, treatment and prognosis of this disease. METHODS: We performed a Pubmed and Embase systematic review for case report reporting the ADV infection to analyze the clinical characteristics of disease. RESULTS: Initial database searched identified articles of which 168 (228 cases) were included in the final analysis. Previous solid organ transplantation [odds ratio (OR) = 3.45, 95% CI 1.31-9.08, P = 0.01], hematopoietic stem cell transplant (OR = 4.24, 95% CI 1.33-13.51, P = 0.01) and hematological malignancy (OR = 4.78, 95% CI 1.70-13.46, P = 0.01) were associated with increased risk of disseminated ADV infection. Use of corticosteroids (OR = 3.86, 95% CI 1.21-12.24, P = 0.02) was a significant risk factor for acquiring urinary tract infections. A total of six species (21 types) of ADV infection have been identified in 100/228 (43.9%) cases. ADV B was the most common species. ADV B species (26/60, 52.0% or 5/41, 12.2% P = 0.001) were more isolated in patients with ADV pneumonia. ADV C (13/15, 86.7% versus 35/86, 40.7% P = 0.001) species were more identified in patients with disseminated disease. The species associated with keratoconjunctivitis is only ADV D in our analysis. Urinary tract ADV infections were observed in ADV A/B/D species. Cidofovir (CDV) (82/228, 36.0%) remained the most commonly antiviral therapy in our cases, followed by ribavirin (15/228, 6.6%), ganciclovir (18/228, 7.9%), and brincidofovir (12/228, 5.3%). Brincidofovir was administered as salvage therapy in 10 cases. Death was reported in 81/228 (35.5%) patients. Mortality rate was higher among patients with gastrointestinal (GI) ADV infection (5/10, 50.0%), ADV pneumonia (20/45, 44.4%) and disseminated ADV infection (53/122, 43.4%). CONCLUSION: Previous solid organ transplantation, hematopoietic stem cell transplant and hematological malignancy were risk factors for disseminated ADV infection. Use of corticosteroids was significant for urinary tract ADV infection. Different species correlated with different clinical manifestations of infection. Mortality rate was higher among patients with GI disease, pneumonia and disseminated disease. Our review clarified the current treatment of ADV infections, and more treatment required further investigation.
OBJECTIVE: The clinical characteristics of various adenovirus (ADV) infection are underexplored up till now. To investigate the risk factors, manifestation, current status of ADV species, treatment and prognosis of this disease. METHODS: We performed a Pubmed and Embase systematic review for case report reporting the ADV infection to analyze the clinical characteristics of disease. RESULTS: Initial database searched identified articles of which 168 (228 cases) were included in the final analysis. Previous solid organ transplantation [odds ratio (OR) = 3.45, 95% CI 1.31-9.08, P = 0.01], hematopoietic stem cell transplant (OR = 4.24, 95% CI 1.33-13.51, P = 0.01) and hematological malignancy (OR = 4.78, 95% CI 1.70-13.46, P = 0.01) were associated with increased risk of disseminated ADV infection. Use of corticosteroids (OR = 3.86, 95% CI 1.21-12.24, P = 0.02) was a significant risk factor for acquiring urinary tract infections. A total of six species (21 types) of ADV infection have been identified in 100/228 (43.9%) cases. ADV B was the most common species. ADV B species (26/60, 52.0% or 5/41, 12.2% P = 0.001) were more isolated in patients with ADV pneumonia. ADV C (13/15, 86.7% versus 35/86, 40.7% P = 0.001) species were more identified in patients with disseminated disease. The species associated with keratoconjunctivitis is only ADV D in our analysis. Urinary tract ADV infections were observed in ADV A/B/D species. Cidofovir (CDV) (82/228, 36.0%) remained the most commonly antiviral therapy in our cases, followed by ribavirin (15/228, 6.6%), ganciclovir (18/228, 7.9%), and brincidofovir (12/228, 5.3%). Brincidofovir was administered as salvage therapy in 10 cases. Death was reported in 81/228 (35.5%) patients. Mortality rate was higher among patients with gastrointestinal (GI) ADV infection (5/10, 50.0%), ADV pneumonia (20/45, 44.4%) and disseminated ADV infection (53/122, 43.4%). CONCLUSION: Previous solid organ transplantation, hematopoietic stem cell transplant and hematological malignancy were risk factors for disseminated ADV infection. Use of corticosteroids was significant for urinary tract ADV infection. Different species correlated with different clinical manifestations of infection. Mortality rate was higher among patients with GI disease, pneumonia and disseminated disease. Our review clarified the current treatment of ADV infections, and more treatment required further investigation.
Authors: Andrea M Lerner; John E Bennett; Stefania Pittaluga; Pavel P Khil; J H Youn; Gary A Fahle; Karen M Frank; John P Dekker; Theresa D Jerussi; Clare Sun; Adrian Wiestner; Juan Gea-Banacloche Journal: Diagn Microbiol Infect Dis Date: 2019-01-02 Impact factor: 2.803
Authors: Allan R Tunkel; Elinor L Baron; Karen A Buch; Francisco M Marty; Maria Martinez-Lage Journal: N Engl J Med Date: 2019-10-10 Impact factor: 91.245
Authors: Tom Wingfield; Luke Dearden; Pete Calvert; Orod Osanlou; Brian Johnston; Anu Chawla; Ian Hart; Catherine Thompson; Lance Turtle; Richard Wenstone Journal: Clin Infect Pract Date: 2019-10
Authors: Wenli Zhang; Kemal Mese; Sebastian Schellhorn; Nora Bahlmann; Nicolas Mach; Oskar Bunz; Akshay Dhingra; Elias Hage; Marie-Edith Lafon; Harald Wodrich; Albert Heim; Anja Ehrhardt Journal: Int J Mol Sci Date: 2020-09-02 Impact factor: 5.923
Authors: Ali A Rabaan; Muhammed A Bakhrebah; Majed S Nassar; Zuhair S Natto; Abbas Al Mutair; Saad Alhumaid; Mohammed Aljeldah; Mohammed Garout; Wadha A Alfouzan; Fatimah S Alshahrani; Tarek Sulaiman; Meshal K AlFonaisan; Mubarak Alfaresi; Saleh A Alshamrani; Firzan Nainu; Shin Jie Yong; Om Prakash Choudhary; Naveed Ahmed Journal: Pathogens Date: 2022-06-21
Authors: Malik Aydin; Ella A Naumova; Friedrich Paulsen; Wenli Zhang; Felix Gopon; Christian Theis; Sören Lutz; Eric Ehrke-Schulz; Wolfgang H Arnold; Stefan Wirth; Anja Ehrhardt Journal: Viruses Date: 2020-10-11 Impact factor: 5.048