Gilles Caty1,2,3, Gregory Reychler4,5,6,7, Elise Piraux8,9,10, Laurette Renard11, David Vancraeynest12,13, Bertrand Tombal14, Xavier Geets11,15. 1. Pôle de Neuro Musculo Skeletal Lab, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium. 2. Clinical Neuroscience, Institute of Neurosciences, Université catholique de Louvain, Brussels, Belgium. 3. Service de médecine physique et réadaptation, Cliniques universitaires Saint-Luc, Brussels, Belgium. 4. Pôle de Pneumologie, ORL & Dermatologie, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium. 5. Haute Ecole Léonard de Vinci, PARNASSE-ISEI, Brussels, Belgium. 6. Secteur de kinésithérapie, Cliniques universitaires Saint-Luc, Brussels, Belgium. 7. Service de Pneumologie, Cliniques universitaires Saint-Luc, Brussels, Belgium. 8. Pôle de Neuro Musculo Skeletal Lab, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium. elise.piraux@uclouvain.be. 9. Pôle de Pneumologie, ORL & Dermatologie, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium. elise.piraux@uclouvain.be. 10. Clinical Neuroscience, Institute of Neurosciences, Université catholique de Louvain, Brussels, Belgium. elise.piraux@uclouvain.be. 11. Department of Radiation Oncology, Cliniques universitaires Saint-Luc, Brussels, Belgium. 12. Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium. 13. Division of Cardiology, Cliniques universitaires Saint-Luc, Brussels, Belgium. 14. Service d'urologie, Cliniques universitaires Saint-Luc, Brussels, Belgium. 15. Molecular Imaging, Radiotherapy and Oncology, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium.
Abstract
BACKGROUND:Exercise training has shown beneficial effects in the management of radiotherapy-related side effects in prostate cancer (PCa) patients undergoing radiation therapy (RT). However, the optimal modality of the exercise programs have not been yet determined. The aim of this randomized controlled trial was to investigate the effects of high-intensity interval training (HIIT) and resistance training (RES) compared to usual care (UC) on cancer-treatment-related fatigue (CTRF) (primary outcome), quality of life, depression, daytime sleepiness, insomnia, sleep quality, functional exercise capacity and executive function in PCa patients during RT. METHODS:PCa patients undergoing RT with or without ADT were randomized in HIIT, RES or UC. Both exercise programs included three sessions per week during 5-8 weeks. HIIT consisted of 8-15 × 60 s intervals (≥85% maximal heart rate). RES was performed with 1-3 sets of 8-12 repetitions for each large muscle groups. The primary outcome was changed in CTRF measured with the Functional Assessment of Chronic Illness Therapy-Fatigue. RESULTS:Seventy-two subjects (69.1 ± 8.2 years) completed the study. No exercise-related adverse events occurred. HIIT (p = 0.012) and RES (p = 0.039) training attenuated increases in CTRF compared to UC. Functional exercise capacity, evaluated by the 6-min walk test, increased after HIIT (p = 0 = 0.43) and RES (p = 0.041) compared to UC (+0.1%). No other secondary variables were different between groups. CONCLUSIONS: Both intervention groups displayed beneficial effects on CTRF and functional exercise capacity in PCa patients undergoing RT. In addition, HIIT and RES are both safe with an excellent attendance rate to the exercise sessions.
RCT Entities:
BACKGROUND: Exercise training has shown beneficial effects in the management of radiotherapy-related side effects in prostate cancer (PCa) patients undergoing radiation therapy (RT). However, the optimal modality of the exercise programs have not been yet determined. The aim of this randomized controlled trial was to investigate the effects of high-intensity interval training (HIIT) and resistance training (RES) compared to usual care (UC) on cancer-treatment-related fatigue (CTRF) (primary outcome), quality of life, depression, daytime sleepiness, insomnia, sleep quality, functional exercise capacity and executive function in PCa patients during RT. METHODS: PCa patients undergoing RT with or without ADT were randomized in HIIT, RES or UC. Both exercise programs included three sessions per week during 5-8 weeks. HIIT consisted of 8-15 × 60 s intervals (≥85% maximal heart rate). RES was performed with 1-3 sets of 8-12 repetitions for each large muscle groups. The primary outcome was changed in CTRF measured with the Functional Assessment of Chronic Illness Therapy-Fatigue. RESULTS: Seventy-two subjects (69.1 ± 8.2 years) completed the study. No exercise-related adverse events occurred. HIIT (p = 0.012) and RES (p = 0.039) training attenuated increases in CTRF compared to UC. Functional exercise capacity, evaluated by the 6-min walk test, increased after HIIT (p = 0 = 0.43) and RES (p = 0.041) compared to UC (+0.1%). No other secondary variables were different between groups. CONCLUSIONS: Both intervention groups displayed beneficial effects on CTRF and functional exercise capacity in PCa patients undergoing RT. In addition, HIIT and RES are both safe with an excellent attendance rate to the exercise sessions.
Authors: Pauline T Truong; Eric Berthelet; Junella C Lee; Ross Petersen; Jan T W Lim; Catherine A Gaul; Howard Pai; Paul Blood; Charles M Ludgate Journal: Can J Urol Date: 2006-06 Impact factor: 1.344
Authors: A L Potosky; J Legler; P C Albertsen; J L Stanford; F D Gilliland; A S Hamilton; J W Eley; R A Stephenson; L C Harlan Journal: J Natl Cancer Inst Date: 2000-10-04 Impact factor: 13.506
Authors: D J Storey; D B McLaren; M A Atkinson; I Butcher; S Liggatt; R O'Dea; J F Smyth; M Sharpe Journal: Ann Oncol Date: 2011-03-24 Impact factor: 32.976